Raimar Loebenberg, PhD, Director DDIC

About

Bio

Dr. Löbenberg holds a BSc in pharmacy from the Johannes Gutenberg-University in Mainz, Germany. He received his PhD in pharmaceutics from the Johann Wolfgang Goethe-University in Frankfurt in 1996. He joined the University of Alberta in 2000. 

His research interests are in Biopharmaceutics to predict the oral performance of drugs and botanicals and inhalable nanoparticles to treat lung diseases like cancer or tuberculosis. 

He is founder and director of the Drug Development and Innovation Centre at the University of Alberta. 

He was president of the Canadian Society for Pharmaceutical Sciences 2014 & 2015.

He is member of the United States Pharmacopeia Dietary Supplement Expert Committee. 

He is Vice Chair of the Specialty Committee of Traditional Chinese Medicine in Pharmaceutics of the World Foundation of Chinese Medicine Science. 

He is member of the Health Canada Scientific Advisory Committee on Pharmaceutical Sciences and Clinical Pharmacology.

Research

Inhalable nanoparticles for pulmonary drug delivery of anti-cancer drugs: This research is performed in collaboration between Engineering, Medicine and Pharmacy. The first publication of this work has received the most cited award of the International Journal of Pharmaceutics in 2004. Our group published several review articles and original research articles (see googelscholar). A patent was issued about the technology. The preclinical application and the high potential of this delivery platform was published in 2011; showing that inhalable nanoparticles are much more potent compared to other routes of administration in lung cancer treatment. We recently applied the technology to tuberculosis.

BCS based development of in vitro/in vivo Correlations using Physiologically adapted Dissolution Techniques and Computers Simulations: This research received the New Investigator Award in 2001 and was/is supported by industry. It generated many publications and was presented at Merck Forsst’s annual research day, FDA-AAPS workshop, AAPS annual conference, Canadian Society for Pharmaceutical Sciences annual conference, SINDUSFARMA (Brazil) Workshop, Pharmaceutical Technology Society of Korea, AAPS outreach workshop South Africa and Argentina and Health Canada.

Quality by Design and performance testing: Publications about this topic have been published in various journals including the AAPS Journal. The work was presented at conferences and workshops in Brazil, China, South Korea, Canada and to the USP expert committee on performance testing. This work has also changed the USP specifications of the disintegration test.

Formulation development and novel processes: Publications about different processes and formulation work, including process analytical technology, were published by my lab. In one project, sponsored by the USP, we investigated blending sequences between an API and two excipients. The results showed that dissolution properties of certain tablets might change depending on blending sequences before compression

TCM and Natural Health Products: The Drug Development and Innovation Centre is involved in translational research to design and develop modern Natural Health Products. Our research is shared at workshops and symposia, and published in several manuscripts. The center has provided several clinical trials with dosage forms and developed prototypes of products which are currently commercialized.

Medical Cannabis: our lab has expertise in the assessment of medical cannabis. We have developed analytical assays and extraction methods for major cannabinoids. We work on modern formulations of medical cannabis a to develop therapeutic alternatives to smoking. Our lab has a cannabis testing and research license.

Teaching

Undergraduate Lectures: Compounding and basic principles in pharmaceutics is given to 130 first and second-year undergraduate students. Topics include : Pharmacopeial Compounding Standards USP Chapter 795, Stability Considerations in Dispensing Practice <1191>, Compounding Powders, Capsules, Suppositories, Solutions, Pharmaceutical Waters, Suppository Bases, Herbal Extraction Processes, Container Materials and Closures; Sterile Compounding USP 797, Sterilization Methods, Parenteral Dosage Forms, Granulation Processes, Tablets, Film Coating, Quality Control and Pharmaceutical Performance Tests, Biopharmaceutics, Biowaivers, Controlled Release, New Drugs and the Drug Approval Process, Natural Heath Products, Future Dosage Forms. 

Seminars: the seminars support the lab exercises and math skills for the students

Laboratory: In the first year instruction is given in compounding and basic pharmaceutics. There is practical training in non sterile liquid, solid, and semi solid dosage forms and their production, documentation and quality control performed in public pharmacies; The second year students have labs about low risk manipulations of sterile products, and dissolution testing and compounding of complex formulations.

Graduate Course in Pharmaceutics: PHARM 611 Pharmaceutical Formulation Development. Topics covered: Statistical Design Approaches in Pharmaceutics using Mini Tab, Regulatory Sciences; FDA Industrial Guidance on SUPAC (IR, MR, SS), BCS, IVIVC, Regulatory differences between Medical Devices and Drugs, Industrial Analytical Assay Development, GLP and GMP Requirements, Dissolution Testing, Quality by Design, In vitro modeling of Dosage Form Effects on the Oral Performance of Drugs.

PHARM 202 - Pharmaceutics 1

Introduces students to the principles of pharmaceutical dosage forms. This course will focus on factors affecting the physical and chemical behavior of drug products, the rationale underlying their formulation, and compounding techniques of pharmaceutical preparations. (Restricted to Pharmacy students.)

PHARM 302 - Pharmaceutics 2

Provides students with fundamental knowledge of physicochemical and biological factors that affect the manufacturing, compounding, application, and behaviour of drug products and pharmaceutical dosage forms. This course explores the rationale underlying, as well as the standards governing, the formulation and quality control of pharmaceutical preparations. Emphasis on advanced dosage forms, biologicals as pharmaceuticals, and more complex compounding practices. (Restricted to Pharmacy students.)

PHARM 611 - Pharmaceutical Formulation and Development

Theoretical considerations basic to the technology of pharmaceutical dosage forms to meet the requirements of therapeutic efficacy, stability, and safety. Laboratory: development and formulation of pharmaceutical products. Prerequisite: consent of Faculty.

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