Stephane Bourque

Area of Study / Keywords

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About

Dr. Stephane Bourque is currently appointed as Associate Professor in the Department of Anesthesiology & Pain Medicine in the Faculty of Medicine & Dentistry.

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Research

Research Interests
My research interests focus on mechanisms that contribute to normal and accelerated age-related decline in cardiovascular function. My work involves two broad areas of cardiovascular pharmacology. The first focuses on mechanisms by which anesthetic agents (and other pharmacological agents) affect vascular function and blood pressure regulation; my laboratory works closely with colleagues in the Departments of Anesthesiology and Pain Medicine and Surgery to address important clinical issues (e.g. perioperative hypotension, sepsis, anemia) that impact surgical outcomes and subsequent patient recovery, particularly in the elderly. The second area focuses on mechanisms by which stressors during pregnancy alter the developmental trajectory of the fetus, which in turn influence the offspring’s susceptibility to chronic diseases in later life. The developing fetus is highly vulnerable to insults (e.g. iron deficiency, hypoxia) which can induce lasting functional changes in key organ systems that progress with time, resulting in accelerated age-related decline. By extension, targeted therapies during critical windows of development may provide protection and confer long-term health benefits to the offspring. My laboratory employs a number of strategies to understand how prenatal stressors and therapeutics impact fetal development and long-term cardiovascular health in the offspring.

Funding Sources
Canadian Institutes for Health Research 
Canadian Foundation for Innovation
Women and Children’s Health Research Institute
University Hospital Foundation
Alberta Innovates - Health Solutions

Jahandideh F., Bourque S.L., Wu J.

Food Chemistry-X. 2022 March; 13 10.1016/j.fochx.2022.100222

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Jahandideh F., Panahi S., Noble R.M.N., Gragasin F.S., Khadaroo R.G., Macala K.F., Bourque S.L.

Biomedicines. 2022 February; 10 (2) 10.3390/biomedicines10020470

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Roberts H., Woodman A.G., Baines K.J., Jeyarajah M.J., Bourque S.L., Renaud S.J.

ENDOCRINOLOGY. 2021 December; 162 (12) 10.1210/endocr/bqab215

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Zhang M, Montroy J, Sharma R, Fergusson DA, Mendelson AA, Macala KF, Bourque SL, Schlechte JM, Eng MK, McDonald B, Gill SE, Fiest KM, Liaw PC, Fox-Robichaud A, Lalu MM.

Critical Care Explorations. 2021 June; 3 (6):e0433 10.1097/CCE.0000000000000433.

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Woolsey AJ, Nanji JA, Moreau C, Sivapalan S, Bourque SL, Ceccherini-Nelli A, Gragasin FS.

Brazilian Journal of Psychiatry. 2021 May; 10.1590/1516-4446-2020-1705.

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Gragasin FS, Ospina MB, Serrano-Lomelin J, Kim SH, Kokotilo M, Woodman AG, Renaud SJ, Bourque SL.

Journal of Clinical Medicine. 2021 March; 10 (5):997 10.3390/jcm10050997.