Maya Shmulevitz

About

Dr. Maya Shmulevitz is currently appointed as Professor in the Department of Medical Microbiology & Immunology in the Faculty of Medicine & Dentistry.

Research

Dr. Shmulevitz has a research lab website here https://shmulevitzlab.weebly.com/

PUBLICATIONS:

Le Bouch M, Jackquet E, Nhiri N, Shmulevitz M, Jais PH (2024) Rational design of an artificial tethered enzyme for non-templated post-transcriptional mRNA polyadenylation by the second generation of the C3P3 system. Sci Rep  Mar 2;14(1):5156. doi: 10.1038/s41598-024-55947-0.

Cristi F, Walters M, Narayan N, Agopsowicz K, Hitt M,  Shmulevitz M. (2023) Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachment. Molecular Therapy - Oncolytics. Mol Ther Oncolytics. Nov 2;31:100743. doi: 10.1016/j.omto.2023.100743

Lin QF, Wong CXL, Eaton HE, Pang X, Shmulevitz M. (2023) Reovirus genomic diversity confers plasticity for protease utility during adaptation to intracellular uncoating. J Virol. Sep 25:e0082823. doi: 10.1128/jvi.00828-23. Epub ahead of print. PMID: 37747236.

Meier-Stephenson V, Evans D, Hobman T, Marchant D, Noyce R, Shmulevitz M. (2023) Special Issue of the 4th Symposium of the Canadian Society for Virology 2022. Viruses. 2023 Jul 6;15(7):1512. doi: 10.3390/v15071512. PMID: 37515198; PMCID: PMC10385079.

Mohamed A, Lin QF, Eaton HE, Shmulevitz M. (2023) p38 Mitogen-Activated Protein Kinase Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Capsid Uncoating, and Postuncoating Steps. J Virol. 2023 Feb 28;97(2):e0000923. doi: 10.1128/jvi.00009-23. Feb 28;97(2):e0000923 PMID: 36744961; PMCID: PMC9972948. (Chosen for Editor’s pick)

Kniert J, Dos Santos T, Eaton HE, Jung Cho W, Plummer G, Shmulevitz M. (2023) Reovirus uses temporospatial compartmentalization to orchestrate core versus outercapsid assembly. PLoS Pathog. 2022 Sep 13;18(9):e1010641. doi: 10.1371/journal.ppat.1010641. PMID: 36099325; PMCID: PMC9514668.

Cristi F, Gutierrez T, Hitt MM, Shmulevitz M. (2022) Genetic Modifications That Expand Oncolytic Virus Potency. Front Mol. Biosci. Jan 26;9:831091. doi: 10.3389/fmolb.2022.831091.

Yip WK, Cristi F, Trifonov G, Narayan N, Kubanski M, Shmulevitz M. (2021) The reovirus µ2 C-terminal loop inversely regulates NTPase and transcription functions versus binding to factory-forming µNS and promotes replication in tumorigenic cells. J Virol. Mar 3:JVI.02006-20. doi: 10.1128/JVI.02006-20.

Kniert J., Lin WR., Shmulevitz M. (2021) Captivating Perplexities of Spinareovirinae 50 RNA Caps. Viruses Feb 13;13(2):294. doi: 10.3390/v13020294.

Mohamed A, Konda P, Eaton HE, Gujar S, Smiley JR, Shmulevitz M. (2020) Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding σ3 respectively. PLoS Pathog. Sep 21;16(9) doi: 10.1371/journal.ppat.1008803.

Mohamed A, Smiley JR, Shmulevitz M. (2020) Polymorphisms in the Most Oncolytic Reovirus Strain Confer Enhanced Cell Attachment, Transcription, and Single-Step Replication Kinetics. J Virol. Jan 31;94(4). doi: 10.1128/JVI.01937-19. (Chosen for spotlight DOI: 10.1128/JVI.02070-19)

Mohamed A, Clements DR, Gujar SA, Lee PW, Smiley JR, Shmulevitz M. Single Amino Acid Differences between Closely Related Reovirus T3D Lab Strains Alter Oncolytic Potency In Vitro and In Vivo (2020). J Virol. Jan 31;94(4). doi: 10.1128/JVI.01688-19. (Chosen for spotlight DOI: 10.1128/JVI.02070-19)

Philip A., Perry J., Eaton H., Shmuleitz M., Hyser, JH., Patton, J. (2019) Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System. J Virol. 2019 Oct 9. pii: JVI.01616-19. doi: 10.1128/JVI.01616-19.

 Fernandes PJ., Cristi F., Eaton HE, Chen P., Haeflinger S., Bernard I., Hitt MM., Shmulevitz M. (2019) Breast tumor-associated metalloproteases restrict reovirus oncolysis by cleaving the σ1 cell-attachment protein, and can be overcome by mutation of σ1. J Virol. Aug 28. 93(2)  pii: JVI.01380-19. doi:10.1128/JVI.01380-19. (Chosen for spotlight DOI: 10.1128/JVI.01548-19)

Jaïs, PH., Decroly, E., Jacquet, E., Le Boulch, M., Jaïs, A., Jean-Jean, O., Eaton, H., Ponien, P., Verdier, F., Canard, B., Goncalves, S., Chiron, S., Le Gall, M., Mayeux, P., Shmulevitz, M. (2019) C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system. Nucleic Acids Res. Mar 18;47(5):2681-2698. doi: 10.1093/nar/gkz069.

Bourhill, T., Mori, Y., Rancourt, D.E., Shmulevitz, M., Johnston, R.N. (2018) Going (reo) Virol: Factors

Teaching

MMI 415 /515 Advanced Virology

• Shmulevitz Lab Website