A Shuaib

Area of Study / Keywords

mechanisms of ischemia clinical trials in acute stroke and stroke prevention translational research in stroke

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About

Personal Statement:

Time is key in treating stroke. Every minute of stroke kills about two million brain cells. My work integrates research and clinical advances to provide the best possible care for stroke. My goal is to minimize stroke brain damage and related disabilities, which are and very expensive to care for over a patient’s lifetime. Our innovative stroke ambulance, for example, provides much better access to stroke care within the critical window of time for rural patients than was previously available, which is very important in Alberta.

Dr. Ashfaq Shuaib received his medical training at Khyber Medical College in Pakistan and his post-graduate training in Internal Medicine and Neurology at the University of Calgary. He training in cerebrovascular research at the University of Western Ontario and Duke University Medical School in Durham, North Carolina.

He returned to Canada as an assistant professor in medicine and neurology at the University of Saskatchewan, becoming professor in 1995.  In addition, he was director of the Division of Neurology between 1990 and 1995, supervised numerous research fellows and graduate students and was director of the Saskatchewan Stroke Research Centre and the WHO Centre.

He joined the University of Alberta as professor of medicine and director of the Division of Neurology in 1997.  

Leadership and Collaborations:

Dr. Shuaib is director of the University of Alberta Stroke Program which, in 2016, launched the first stroke ambulance in Alberta. He chairs the National Stroke Program and the National Residents’ Review Course and is on the board of the Canadian Stroke Consortium. He is very involved in clinical trials and is currently on steering committees of five large multicenter acute stroke trials. Previously, he chaired the steering committees of large multicentre trials of the SAINT II and SENTIS trials. In he has started a clinical trial in patients with TIAs and minor stroke with ten participating sites in the Middle East. During his time as divisional director of Neurology in the Department of Medicine, he started a stroke prevention clinic in Edmonton and established a stroke investigative unit at the University of Alberta Hospital. 

Clinical Interests

Dr. Shuaib is director of the Stroke Prevention Clinic which he established in 1997. He sees patients in the clinic and is actively involved in of acute stroke patients at the University of Alberta Hospital.

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Research

Dr. Shuaib’s major interests are in the understanding of the basic mechanisms of cerebral ischemia and developing clinical trials in cerebrovascular diseases. He has published over 400 articles in peer-reviewed journals and his research funding includes support from the Canadian Institutes of Health Research, Heart and Stroke Foundation of Alberta, National Institutes of Health, the former Alberta Heritage Foundation for Medical Research and industry. He is on the editorial board of Stroke, Neurohospitalist, Journal of Neuroscience (Pakistan), Post-Graduate Journal (Pakistan), Heart Org, and is an associate editor of Frontiers in Neuroscience and Faculty F-1000.

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Teaching

Dr. Shuaib’s clinical stroke program currently has nine neurologists with specialist stroke training and four to five fellows in training (one-to-two-year fellowship program), making it one of the largest such training programs in the country.

Khan A., De Boever P., Gerrits N., Akhtar N., Saqqur M., Ponirakis G., Gad H., Petropoulos I.N., Shuaib A., Faber J.E., Kamran S., Malik R.A.

PLoS ONE. 2022 May; 17 (5 May) 10.1371/journal.pone.0267837

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Mohamed A, Fatima N, Ahmed AZ, Shuaib A, Saqqur M

Research Square. 2022 May; 10.21203/rs.3.rs-386972/v2

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Akhtar N, Singh R, Kamran s, Babu B, Sivasankaran S, Joseph S, Morgan D, Shuaib A

Frontiers in Neurology. 2022 April; 10.3389/fneur.2022.849607

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Akhtar N., Abid F., Singh R., Kamran S., Imam Y., Al Jerdi S., Salameh S., Al Attar R., Yasir M., Shabir H., Morgan D., Joseph S., AlMaslamani M., Shuaib A.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2022 March; 53 (4):824-828 10.1007/s11239-021-02581-6

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Aldous E.K., Toor S.M., Parray A., Al-Sarraj Y., Diboun I., Abdelalim E.M., Arredouani A., El-Agnaf O., Thornalley P.J., Akhtar N., Pananchikkal S.V., Shuaib A., Alajez N.M., Albagha O.M.E.

International Journal of Medical Sciences. 2022 March; 23 (6) 10.3390/ijms23063387

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Ponirakis G, Al Hamad H, Khan A, Petyropoulos IN, Gad H, Chandran M, Elsotouhy A, Ramadan M, Gawhale PV, Elorrabi M, Gadelseed M, Tosino R, Arasn A, Manikoth P, Abdelrahim Y, Refaee MA, Thodi N, Vattoth S, Almuhannadi H, Mahfoud ZR, Bhat H, Own A, Shuaib A, Malik R.

Alzheimer's Dementia. 2022 March; 8 (e12269) 10.1002/trc2.12269

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Al Jerdi S., Akhtar N., Mahfoud Z., Kamran S., Shuaib A.

BMJ Open. 2022 March; 12 (3):e053059 10.1136/bmjopen-2021-053059

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Akhtar N., Kamran S., Al-Jerdi S., Imam Y., Joseph S., Morgan D., Abokersh M., Uy R.T., Shuaib A.

PLoS One. 2022 March; 17 (3 March) 10.1371/journal.pone.0255185

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Stroke. 2022 February;

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Khan A., Parray A., Akhtar N., Agouni A., Kamran S., Pananchikkal S.V., Priyanka R., Gad H., Ponirakis G., Petropoulos I.N., Chen K.H., Tayyab K., Saqqur M., Shuaib A., Malik R.A.

Scientific Reports. 2022 February; 12 (1) 10.1038/s41598-022-07353-7

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Stroke. 2022 February;

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Stroke. 2022 February;

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Stroke. 2022 February;

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Stroke. 2022 February;

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Nomani A.Z., Rempel J.L., Khan K.A., Shuaib A., Jickling G.C.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES. 2022 January; 10.1017/cjn.2022.9

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Ishaque N., Butt A.J., Kamtchum-Tatuene J., Nomani A.Z., Razzaq S., Fatima N., Vekhande C., Nair R., Akhtar N., Khan K., Saqqur M., Shuaib A.

Journal of Stroke. 2022 January; 24 (1):65-78 10.5853/jos.2021.01571

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Al Hashmi A., von Bandemer S., Shuaib A., Mansour O.Y., Wassy M., Ozdemir A.O., Farhoudi M., Al Jehani H., Khan A., John S., Saqqur M.

Journal of Neurological Sciences-Turkish. 2022 January; 432 (1):65-78 10.1016/j.jns.2021.120060

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Siddique M., Butt A., Sultan N., Ahmed F., Shuaib A.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES. 2022 January; 10.1017/cjn.2022.25

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Buck B, Akhtar N, Alrohimi A, Khan K, Shuaib A

ANNALS OF MEDICINE. 2021 December; 53 (1):420-436 10.1080/07853890.2021.1890205

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H. Buck B., Akhtar N., Alrohimi A., Khan K., Shuaib A.

ANNALS OF MEDICINE. 2021 December; 53 (1):420-436 10.1080/07853890.2021.1890205

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Yousif G., Qadri S., Parray A., Akhthar N., Shuaib A., Haik Y.

NEUROMOLECULAR MEDICINE. 2021 November; 10.1007/s12017-021-08696-6

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Akhtar N, Al-Jerdi S, Kamran S, Singh R, Babu B, Abdelmoneim MS, Morgan D, Joseph S, Francis R, Shuaib A

Frontiers in Neurology. 2021 November; 12 (719311) 10.3389/fneur.2021.71931

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Zerna C., Rogers E., Rabi D.M., Demchuk A.M., Kamal N., Mann B., Jeerakathil T., Buck B., Shuaib A., Rempel J., Menon B.K., Goyal M., Hill M.D.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES. 2021 October; 48 (4):479-486 10.1017/cjn.2020.237

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Mehrpour M., Zamani B., Shadnoush M., Kermanchi J., Hozhabri S., Aghaali M., Shuaib A., Sharifipour E.

Archives of Iranian Medicine. 2021 August; 24 (8):651-652 10.34172/aim.2021.92

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Ganesh A., Menon B.K., Assis Z.A., Demchuk A.M., Al-Ajlan F.S., Al-Mekhlafi M.A., Rempel J.L., Shuaib A., Baxter B.W., Devlin T., Thornton J., Williams D., Poppe A.Y., Roy D., Krings T., Casaubon L.K., Kashani N., Hill M.D., Goyal M.

JAMA Network Open. 2021 July; 16 (5):593-601 10.1177/1747493020929943

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Buck B.H., Hill M.D., Quinn F.R., Butcher K.S., Menon B.K., Gulamhusein S., Siddiqui M., Coutts S.B., Jeerakathil T., Smith E.E., Khan K., Barber P.A., Jickling G., Reyes L., Save S., Fairall P., Piquette L., Kamal N., Chew D.S., Demchuk A.M., Shuaib A., Exner D.V.

JAMA Neurology. 2021 July; 325 (21):2160-2168 10.1001/jama.2021.6128

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Zerna C., Rogers E., Rabi D.M., Demchuk A.M., Kamal N., Mann B., Jeerakathil T., Buck B., Shuaib A., Rempel J., Menon B.K., Goyal M., Hill M.D.

Canadian Journal of Neurological Sciences. 2021 July; 48 (4):479-486 10.1017/cjn.2020.237

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Almekhlafi MA, Goyal M, Dippel DWJ, Majoie CBLM, Campbell BCV, Muir KW, Demchuk AM, Bracard S, Guilemmin F, Jovin TG, Mitchell P, White P, Hill MD, Brown S, Saver JL: HERMES Trialists Collaboration

JAMA Neurology. 2021 June; 78 (6):709-717 10.1001/jamaneurol.2021.1055

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Noguira RG, Qureshi MM, Abdalkader M, ....Nguyen TN: SVIN COVID 19 Global Stroke Registry

NEUROLOGY. 2021 June; 96 (23):e2824-e2838 10.1212/WNL.0000000000011885

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Mohamed A., Fatima N., Shuaib A., Saqqur M.

Frontiers in Neuroscience. 2021 June; 12 (1):E301-E304 10.33989/fnins.2021.690896

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Buck BH, Hill MD, Quinn FR, Butcher KS, Menon BK, Gulamhusein S, Siddiqui M, Coutts SB, Jeerakathil T, Smith EE, Khan K, Barber PA, Jickling G, Reyes L, Save S, Fairall P, Piquette L, Kamal N, Chew DS, Demchuk AM, Shuaib A, Exner DV

JAMA Neurology. 2021 June; 325 (21):2160-2168 10.1001/jama.2021.6128

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Alrohimi A., Buck B., Jickling G., Shuaib A., Thirunavukkarasu S., Butcher K.S.

JOURNAL OF NEUROLOGY. 2021 May; 268 (5):1837-1846 10.1007/s00415-020-10335-2

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Kate M., Gioia L., Asdaghi N., Jeerakathil T., Shuaib A., Buck B., Emery D., Beaulieu C., Butcher K.

Canadian Journal of Neurological Sciences. 2021 May; 48 (3):349-357 10.1017/cjn.2020.179

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Mohamed A., Fatima N., Shuaib A., Saqqur M.

International Journal of Stroke. 2021 April; 12 (1):E301-E304 10.1177/17474930211013285

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Irfan F.B., Castren M., Bhutta Z.A., George P., Qureshi I., Thomas S.H., Pathan S.A., Alinier G., Shaikh L.A., Suwaidi J., Singh R., Shuaib A., Tariq T., McKenna W.J., Cameron P.A., Djarv T.

ETHNICITY & HEALTH. 2021 April; 26 (3):460-469 10.1080/13557858.2018.1530736

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Perkins J.D., Wilkins S.S., Kamran S., Shuaib A.

Neurobiology of Stress. 2021 April; 14 10.1016/j.ynstr.2021.100332

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Kate M.P., Jeerakathil T., Buck B.H., Khan K., Nomani A.Z., Butt A., Thirunavukkarasu S., Nowacki T., Kalashyan H., Lloret-Villas M.I., D’Souza A., Mishra S., McCombe J., Butcher K., Jickling G., Saqqur M., Shuaib A.

Scientific Reports. 2021 March; 11 (1):E301-E304 10.1038/s41598-021-84441-0

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Alrohimi A., Jickling G., Jeerakathil T., Shuaib A., Khan K., Kate M., Hill M.D., Buck B., Butcher K.

Frontiers in Neurology. 2021 March; 12 (1):E301-E304 10.3389/fneur.2021.645822

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Yousif G., Qadri S., Haik M., Haik Y., Parray A.S., Shuaib A.

Molecular Diagnosis and Therapy. 2021 March; 25 (2):163-180 10.1007/s40291-020-00508-0

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Sevick LK, Demchuk AM, Shuaib A, Smith EE, Rempel JL, Butcher K, Menon BK, Jeerakathil T, Kamal N, Thornton J, Williams D, Poppe AY, Roy D, Goyal M, Hill MD, Clement F, ESCAPE Trialists

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES. 2021 January; 11 (1):E301-E304 10.1017/cjn.2021.4

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Akhtar N, Al Jerdi S, Mahfoud Z, Imam Y, Kamran S, Saqqur M, Morgan D, Joseph S, Khan K, Shuaib A

BMJ Neurology Open. 2021 January; 3 (1) 10.1136/bmjno-2020-000084

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Salam A., Kamran S., Bibi R., Korashy H.M., Parray A., Mannai A.A., Ansari A.A., Kanikicharla K.K., Gashi A.Z., Shuaib A.

Journal of Stroke and Cerebrovascular Diseases. 2020 December; 29 (12) 10.1016/j.jstrokecerebrovasdis.2020.104768

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Ahmed Z.M., Khalil M.F., Kohail A.M., Eldesouky I.F., Elkady A., Shuaib A.

Journal of Stroke and Cerebrovascular Diseases. 2020 December; 29 (12) 10.1016/j.jstrokecerebrovasdis.2020.105315

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Saqqur M., Salam A., Ayyad A., Akhtar N., Ali M., Khan A., Imam Y., Joseph S., Jerdi S.A., Shuaib A.

Clinical Neurology and Neurosurgery. 2020 December; 199 10.1016/j.clineuro.2020.106255

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Akhtar N., Abid F.B., Kamran S., Singh R., Imam Y., AlJerdi S., AlMaslamani M., Shuaib A.

Journal of Stroke & Cerebrovascular Diseases. 2020 November; 30 (1):E301-E304 10.1016/j.jstrokecerebrovasdis.2020.105435

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Amarenco P., Denison H., Evans S.R., Himmelmann A., James S., Knutsson M., Ladenvall P., Molina C.A., Wang Y., Johnston S.C., THALES Steering Committee and Investigators

Stroke. 2020 November; 51 (12):3504-3513 10.1161/STROKEAHA.120.032239

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Amarenco P., Denison H., Evans S.R., Himmelmann A., James S., Knutsson M., Ladenvall P., Molina C.A., Wang Y., Johnston S.C., THALES Steering Committee and Investigators

JAMA Neurology. 2020 November; 78 (2):1-9 10.1001/jamaneurol.2020.4396

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Al Hashmi A.M., Ozdemir A.O., Shuaib A., Al-Jehani H., Mansour O.Y., Alhazzani A., Aladhem F., Farhoudi M., John S., Saqqur M.

Journal of Stroke and Cerebrovascular Diseases. 2020 November; 29 (11):1233-1240 10.1016/j.jstrokecerebrovasdis.2020.105181

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Abootalebi S., Aertker B.M., Andalibi M.S., Asdaghi N., Aykac O., Azarpazhooh M.R., Bahit M.C., Barlinn K., Basri H., Shahripour R.B., Bersano A., Biller J., Borhani-Haghighi A., Brown R.D., Campbell B.C., Cruz-Flores S., De Silva D.A., Napoli M.D., Divani A.A., Edgell R.C., Fifi J.T., Ghoreishi A., Hirano T., Hong K.S., Hsu C.Y., Huang J.F., Inoue M., Jagolino A.L., Kapral M., Kee H.F., Keser Z., Khatri R., Koga M., Krupinski J., Liebeskind D.S., Liu L., Ma H., Maud A., McCullough L.D., Meyer D.M., Mifsud V., Morovatdar N., Nilanont Y., Oxley T.J., Özdemir A.Ö., Pandian J., Pantoni L., Papamitsakis N.I.H., Parry-Jones A., Phan T., Rodriguez G., Romano J.G., Sabaa-Ayoun Z., Saber H., Sasannezhad P., Saver J.L., Scharf E., Shuaib A., Silver B., Singhal S., Smith C.J., Stranges S., Sylaja P.N., Torbey M., Toyoda K., Tsivgoulis G., Wasay M., Yassi N., Yoshimoto T., Zamani B., Zand R.

Journal of Stroke and Cerebrovascular Diseases. 2020 September; 29 (9) 10.1016/j.jstrokecerebrovasdis.2020.104938

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Lloret-Villas M.I., Butt A., Khan K., Shuaib A.

Stroke. 2020 September; 51 (11):E301-E304 10.1161/STROKEAHA.120.030709

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Alrohimi A., Ng K., Dowlatshahi D., Buck B., Stotts G., Thirunavukkarasu S., Shamy M., Kalashyan H., Sivakumar L., Shuaib A., Sharma M., Butcher K.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES. 2020 September; 47 (5):604-611 10.1017/cjn.2020.84

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Fatima N., Shuaib A., Saqqur M.

CLINICAL NEUROLOGY AND NEUROSURGERY. 2020 September; 196 10.1016/j.clineuro.2020.106069

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Imam Y.Z., Kamran S., Saqqur M., Ibrahim F., Chandra P., Perkins J.D., Malik R.A., Akhtar N., Al-Jerdi S., Deleu D., Elalamy O., Osman Y., Malikyan G., Elkhider H., Elmakki S., ElSheikh L., Mhjob N., Abdelmoneim M.S., Alkhawad N., Own A., Shuaib A.

PLoS One. 2020 September; 15 (9 September):e368-e377 10.1371/journal.pone.0238865

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Parray A., Ma Y., Alam M., Akhtar N., Salam A., Mir F., Qadri S., Pananchikkal S.V., Priyanka R., Kamran S., Winship I.R., Shuaib A.

Brain Research. 2020 August; 1740 10.1016/j.brainres.2020.146860

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Fatima N., Saqqur M., Qamar F., Shaukat S., Shuaib A.

JOURNAL OF THE NEUROLOGICAL SCIENCES. 2020 August; 41 (10):2675-2679 10.1007/s10072-020-04637-6

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Al-Jehani H., John S., Hussain S.I., Al Hashmi A., Alhamid M.A., Amr D., Ozdemir A.O., Shuaib A., Alhazzani A., Ghorbani M., Mansour O., Saqqur M.

Frontiers in Neurology. 2020 August; 11 (12):1524-1535 10.3389/fneur.2020.00928

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Fatima N., Saqqur M., Hussain M.S., Shuaib A.

International Journal of Stroke. 2020 August; 15 (6):595-608 10.1177/1747493020929964

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Kamtchum-Tatuene J., Noubiap J.J., Wilman A.H., Saqqur M., Shuaib A., Jickling G.C.

JAMA Neurology. 2020 August; 77 (12):1524-1535 10.1001/jamaneurol.2020.2658

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Kamal N., Jeerakathil T., Stang J., Liu M., Rogers E., Smith E.E., Demchuk A.M., Siddiqui M., Mann B., Bestard J., Lang E., Shand E., Benard M., Collins L., Martin K., Hartley C., Reiber M., Valaire S., Mrklas K.J., Hill M.D., QuICR Alberta Stroke Program

Stroke. 2020 August; 51 (8):2339-2346 10.1161/STROKEAHA.120.029734