Directory

Sehrish Javed, PhD

ATS Assistant Lecturer, ENG Biomedical Engineering

Pronouns: She/her

Contact Overview Publications

Contact

ATS Assistant Lecturer, ENG Biomedical Engineering
Email
sjaved3@ualberta.ca

Overview

Area of Study / Keywords

Neural engineering genetic engineering neural circuits neurobionics behavioral genetics neuromodulation hypothalamus energy metabolism neurodevelopmental disorders

About

Education:

  • 2019-2023       Doctor of Philosophy (PhD), Integrated Program in Neuroscience, McGill University, Canada
  • 2017-2019       Masters (MS), Biological Sciences, Korea Advanced Institute of Sciences and Technology, South Korea
  • 2012-2016       Bachelors (BS), Applied Biosciences, Major: Healthcare Biotechnology, National University of Sciences and Technology, Pakistan


Research

My expertise lies in using various neuro-modulatory techniques (Genetics, Pharmacological, Optical & Electrical)  to stimulate neurons in the brain, aiming to decipher how these neurons regulate behavior under normal conditions and how can we modulate the neural circuits in the context of disease. 

Research Interests:

  • Transcriptomic and proteomic profiling of genes and proteins linked to neurodevelopmental disorders.  
  • Investigating subcortical neural circuits involved in energy homeostasis. 
  • Studying neural circuitry related to sensory, motor, and autonomic functions.
  • Utilizing gene editing techniques to explore neural circuits mechanisms. 
  • Applying neuromodulation approaches for neural engineering and therapeutic interventions. 

Teaching

Winters 2025:

BME 530: Introduction to the Neurobionics

Course Description: 

  • Develop understanding of the neurological  mechanisms that define the characteristics and properties of the bionic devices. 
  • Topics include the use of neuromodulation as a tool for enhancing sensory, motor, and  cognitive function in both health and disease. 
  • Examples include bionic senses (bionic vision, auditory bionic, bionic touch) and the neuromodulation-based therapies for treating neurological disorders. 
  • The course also covers ethical considerations and the future potential of medical neurobionics.  


Featured Publications

Comparative analyses of the Smith− Magenis syndrome protein RAI1 in mice and common marmoset monkeys

Ya‐Ting Chang, Yu‐Ju Lee, Minza Haque, Hao‐Cheng Chang, Sehrish Javed, Yu Cheng Lin, Yoobin Cho, Joseph Abramovitz, Gabriella Chin, Asma Khamis, Reesha Raja, Keith K Murai, Wei‐Hsiang Huang

2024 January; 10.1002/cne.25589

Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

Sehrish Javed, Ya-Ting Chang, Yoobin Cho, Yu-Ju Lee, Hao-Cheng Chang, Minza Haque, Yu Cheng Lin, and Wei-Hsiang Huang

2023 November; 10.7554/eLife.90333

rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice

Hao-Cheng Chang , Yu-Ju Lee , Sehrish Javed , Minza Haque, Ya-Ting Chang , Yu Cheng Lin , Cameron Oram , Wei-Hsiang Huang

2022 November; 10.1016/j.jbc.2022.102728

Dosage-sensitive genes in autism spectrum disorders: From neurobiology to therapy

Sehrish Javed, Tharushan Selliah, Yu-Ju Lee, Wei-Hsiang Huang

2022 August; 10.1016/j.neubiorev.2020.08.009

Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith–Magenis syndrome

Sehrish Javed, Yu-Ju Lee, Jin Xu, Wei-Hsiang Huang

2021 August; 10.1093/hmg/ddab245

Resveratrol and Alzheimer's Disease: Mechanistic Insights.

Ahmed T, Javed S, Javed S, Tariq A, Šamec D, Tejada S, Nabavi SF, Braidy N, Nabavi SM.

2016 March; 10.1007/s12035-016-9839-9