S Kar

Area of Study / Keywords

neurodegenerative diseases neuroprotection neurodegeneration

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About

Personal Statement: 

Alzheimer’s disease is a devastating and progressive neurodegenerative disease for which we have no cure. My research is aimed at understanding the root causes of Alzheimer’s, specifically components of the neuritic plaques that kill neurons in areas of the brain, with the goal to identify potential treatments for the disease. 

Neuroscientist Dr. Satyabrata Kar received his PhD from Hammersmith Hospital at the University of London. He completed post-doctoral training at Douglas Hospital, McGill University. He is professor in the Department of Medicine’s Division of Neurology and the Department of Psychiatry. He is an intramural faculty member at the Centre for Prions and Protein Folding Diseases and with the Neuroscience and Mental Health Institute.

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Research

Dr. Kar’s research is concerned with the causes of neurodegeneration in people with Alzheimer’s disease and the role that insulin-like factors play in normal and Alzheimer’s brains. One are of his current research looks at causes of specific areas of brain neurodegeneration that involve amyloid peptides and other agents. Dr. Kar has published widely in international journals including Molecular Cell Biology, Human Molecular Genetics and the Journal of Biological Chemistry.

Funding and awards for his research include the Commonwealth scholarship from the UK government, Chercheur-Boursier awards from the Fonds de la Recherche en Sante du Quebec, Senior Scholar from the former Alberta Heritage Foundation for Medical Research and the Young investigator award from the Canadian College of Neuropsychopharmacology. He completed two Tier Two Canada Research Chair awards funded by the Canadian Institutes of Health Research (CIHR). Currently, his research is funded by CIHR, Natural Scientific and Engineering Research Council of Canada, Alberta Prion Research Institute and the Alzheimer Society of Alberta and Northwest Territories.

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Teaching

Dr. Kar offers research training to undergraduate and graduate students in the field of neurodegenerative diseases.

Wu Q, Karthivashan G, Nakhaei-Nejad M, Anand BG, Giuliani F and Kar S

International Journal of Biological Macromilecules. 2022 June; 10.1016/j.ijbiomac.2022.08.148

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Anand B, Wu Q, Nakhaei-Nejad M, Karthivashan G, Dorosh L, Amidian S, Dahal A, Li X, Stepanova M, Wille H, Giuliani F and Kar S.

Bioactive Materials. 2022 June; 17 (506):525 10.1016/j.bioactmat.2022.05.030

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Society for Neuroscience Meeting. 2022 May; In press

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Society for Neuroscience Meeting. 2022 May; In press

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Paul PS, Cho JY, Wu Q, Karthivashan G, Grabovac E, Wille H, Kulka M, Kar S

Journal of Nanobiotechnology. 2022 February; 20 (1):67 10.1186/s12951-022-01269-0

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Matveychuk D, MacKenzie EM, Kumpula D, Song MS, Holt A, Kar S, Todd KG, Wood PL, Baker GB.

Cellular and Molecular Neurobiology. 2022 January; 42 (1):225-242 10.1007/s10571-021-01078-3

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Grant P, Kumar J, Kar S, Overduin M.

Molecules. 2021 December; 26 (24):7669 10.3390/molecules26247669

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Wu Q., Cortez L., Kamali-Jamil R., Sim V., Wille H. and Kar S.

Disease Models and Mechanisms. 2021 July; 14 (10):dmm048929 10.1242/dmm.048929

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B.G. Anand, Q. Wu, G. Karthivashan, K.P. Shejale, S. Amidian, H. Wille, S. Kar

Bioactive Materials. 2021 May; 6 (12):4491-4505 10.1016/j.bioactmat

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Wang Y, Wu Q, Anand B.G., Karthivashan G, Phukan G, Yang J, Thinakaran G, Westaway D and Kar S.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 2020 December; 46 (7):686-706 2020-0016.R2