Directory

Tom Hobman

Professor, Faculty of Medicine & Dentistry - Cell Biology Dept
Contact Overview Publications

Contact

Professor, Faculty of Medicine & Dentistry - Cell Biology Dept
Email
thobman@ualberta.ca
Phone
(780) 492-6485
Address
6-142K Katz Group Centre For Research
11315 - 87 Ave NW
Edmonton AB
T6G 2H5

Overview

Area of Study / Keywords

About

Canada Research Chair in RNA virus host interactions

Research

  1. Investigating how pathogenic viruses (Zika virus, West Nile virus, Dengue virus) causes disease.
  2. Novel diagnostics for Dengue virus and Zika virus.
  3. Identification of indirect-acting antiviral compounds.
  4. Mechanisms by which HIV causes neurological disease (in collaboration with Dr. Chris Power)
  5. Role of the master gene regulator Argonatue 2 in breast cancer.

Featured Publications

Rubella virus

Tom C. Hobman

Fields Virology (7th Edition). 2022 August; 1 Not available yet.

Flavivirus Capsid Proteins Inhibit the Interferon Response

Airo A.M., Felix-Lopez A., Mancinelli V., Evseev D., Lopez-Orozco J., Shire K., Paszkowski P., Frappier L., Magor K.E., Hobman T.C.

Viruses-Basel. 2022 May; 14 (5) 10.3390/v14050968

Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

Nguyen L., McCord K.A., Bui D.T., Bouwman K.M., Kitova E.N., Elaish M., Kumawat D., Daskhan G.C., Tomris I., Han L., Chopra P., Yang T.J., Willows S.D., Mason A.L., Mahal L.K., Lowary T.L., West L.J., Hsu S.T.D., Hobman T., Tompkins S.M., Boons G.J., de Vries R.P., Macauley M.S., Klassen J.S.

Nature Chemical Biology. 2022 January; 18 (1):81-90 10.1038/s41589-021-00924-1

Mayaro virus non-structural protein 2 circumvents the induction of interferon in part by depleting host transcription initiation factor IIE subunit 2

Ishida R., Cole J., Lopez-Orozco J., Fayad N., Felix-Lopez A., Elaish M., Luo S.Y., Julien O., Kumar A., Hobman T.C.

Cells. 2021 December; 10 (12) 10.3390/cells10123510

Infection of glia by human pegivirus suppresses peroxisomal and antiviral signaling pathways

Doan M.A.L., Roczkowsky A., Smith M., Blevins G., van Landeghem F.K.H., Gelman B.B., Branton W.G., Stapleton J.T., Hobman T.C., Power C.

JOURNAL OF VIROLOGY. 2021 September; 95 (23) 10.1128/JVI.01074-21

SARS-CoV-2 nonstructural protein 1 inhibits the interferon response by causing depletion of key host signaling factors

Kumar A., Ishid R., Strilets T., Cole J., Lopez-Orozco J., Fayad N., Felix-Lopez A., Elaish M., Evseev D., Magor K.E., Mahal L.K., Nagata L.P., Evans D.H., Hobman T.C.

JOURNAL OF VIROLOGY. 2021 June; 95 (13) 10.1128/JVI.00266-21

Nodosome inhibition as a novel broad-spectrum antiviral strategy against arboviruses, enteroviruses, and SARS-CoV-2

Limonta D., Dyna-Dagman L., Branton W., Mancinelli V., Makio T., Wozniak R.W., Power C., Hobman T.C.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2021 May; 65 (8) 10.1128/AAC.00491-21

Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells

Knoblach B., Ishida R., Hobman T.C., Rachubinski R.A.

MOLECULAR BIOLOGY OF THE CELL. 2021 May; 32 (14):1273-1282 10.1091/mbc.E21-02-0074

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

Zhang K., Miorin L., Makio T., Dehghan I., Gao S., Xie Y., Zhong H., Esparza M., Kehrer T., Kumar A., Hobman T.C., Ptak C., Gao B., Minna J.D., Chen Z., García-Sastre A., Ren Y., Wozniak R.W., Fontoura B.M.A.

Science Advances. 2021 February; 7 (6) 10.1126/sciadv.abe7386

Endothelium infection and dysregulation by sars-cov-2: Evidence and caveats in covid-19

Bernard I., Limonta D., Mahal L.K., Hobman T.C.

Viruses-Basel. 2020 December; 13 (1) 10.3390/v13010029

Zika Virus and Host Interactions: From the Bench to the Bedside and Beyond

Limonta D., Hobman T.C.

Cells. 2020 November; 9 (11) 10.3390/cells9112463

Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity

Heindel D.W., Koppolu S., Zhang Y., Kasper B., Meche L., Vaiana C.A., Bissel S.J., Carter C.E., Kelvin A.A., Elaish M., Lopez-Orozco J., Zhang B., Zhou B., Chou T.W., Lashua L., Hobman T.C., Ross T.M., Ghedin E., Mahal L.K.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION A-PHYSICAL SCIENCES. 2020 October; 117 (43):26926-26935 10.1073/pnas.2008203117

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

Glasgow A., Glasgow J., Limonta D., Solomon P., Lui I., Zhang Y., Nix M.A., Rettko N.J., Zha S., Yamin R., Kao K., Rosenberg O.S., Ravetch J.V., Wiita A.P., Leung K.K., Lim S.A., Zhou X.X., Hobman T.C., Kortemme T., Wells J.A.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020 October; 117 (45):28046-28055 10.1073/pnas.2016093117