Lusine Tonoyan, PhD

Term Professional, New Graduate Program Development Lead, ENG Biomedical Engineering

Personal Website: https://sites.google.com/ualberta.ca/siraki-arma-lab/bio

Contact Overview Publications

Contact

Term Professional, New Graduate Program Development Lead, ENG Biomedical Engineering

Email: tonoyan@ualberta.ca

Overview

Area of Study / Keywords

Expert in mathematical and computational health sciences AI-driven biomedical research with a focus on pharmacology psychiatric epidemiology and machine learning for translational precision medicine.

Teaching

Machine Learning in Toxicology, PHARM 564,

Advanced Clinical Pharmacokinetics and Pharmacogenomics, PHARM 415,

Analytical Techniques PHARM 573.

Featured Publications

Proteomic identification of protein radicals from myeloperoxidase-mediated mefenamic acid oxidation reveals a mechanism of NSAID-induced oxidative injury

Newton H. Tran, Steven Lockhart, Othman Eldalal, Phuong G. Tran, John-Paul R. Cooper, Lusine Tonoyan, Richard P. Fahlman, Arno G. Siraki

Redox Biochemistry and Chemistry. 2025 December; 10.1016/j.rbc.2025.100066

Mechanisms of Mefenamic Acid-Induced Cytotoxicity: The Role of Myeloperoxidase, Oxidative Distress, and Protein Radical Formation

Newton Tran, Steven Liu, Othman Eldalal, Phuong Tran, Lusine Tonoyan, Richard Fahlman, Arno Siraki

Free Radical Biology and Medicine. 2025 November; 10.1016/j.freeradbiomed.2025.10.152

Cysteine oxidation of a redox hub within complex I can facilitate electron transport chain supercomplex formation

Runtai Chen, Seyed Amirhossein Tabatabaei Dakhili, Rokas Gerulskis, Yuan-Yuan Zhao, Steven Lockhart, Lusine Tonoyan, Arno G. Siraki, Guocheng Huang, Adam Kinnaird, Darren H. Freed, Shelley D. Minteer, Evangelos D. Michelakis, John R. Ussher, Gopinath Sutendra

Journal of Biological Chemistry. 2025 September; 10.1016/j.jbc.2025.110555

Predicting clozapine-induced adverse drug reaction biomarkers using machine learning

John-Paul Cooper, Pierre Chue, Arno G. Siraki & Lusine Tonoyan

Scientific Reports . 2025 July; volume 15 (Article number: 25572 (2025))

Amplex Red cellular uptake produces radical intermediates by myeloperoxidase and mediates oxidative stress

Huan Liu, Lusine Tonoyan, Béla Reiz, Arno G. Siraki

Redox Biochemistry and Chemistry. 2025 June; 10.1016/j.rbc.2025.100051

The Interaction of Myeloperoxidase with the Industrial Contaminant 6-PPD: A Potential Pathway for Reactive Metabolites

Steven Lockhart, Dinesh Babu, Newton H. Tran, Béla Reiz, Lusine Tonoyan, Arno G. Siraki

Chemical Research in Toxicology. 2024 October; 10.1021/acs.chemrestox.4c00265

Application of electron paramagnetic resonance spectroscopy for determining the relative nanoenvironment fluidity of polymeric micelles

Lusine Tonoyan, Sirazum Munira, Afsaneh Lavasanifar, Arno G. Siraki

European Biophysics Journal. 2024 May; 10.1007/s00249-024-01706-y

Machine learning in toxicological sciences: opportunities for assessing drug toxicity

Lusine Tonoyan, Arno G. Siraki

Frontiers in Drug Discovery. 2024 February; 10.3389/fddsv.2024.1336025

The oxidation of fenamic acid NSAIDs by neutrophil myeloperoxidase produces toxic reactive metabolites that induce leukemic cell death

Newton H. Tran, Dinesh Babu, Steven Lockhart, Andrew G. Morgan, Nadine Commandeur, Md Harunur Rashid, Béla Reiz, Lusine Tonoyan, Arno G. Siraki

Redox Biochemistry and Chemistry. 2023 December; 10.1016/j.rbc.2023.100013

Effect of Plasma-Activated Water Bubbles on Fusarium graminearum, Deoxynivalenol, and Germination of Naturally Infected Barley during Steeping

Ehsan Feizollahi, Urmila Basu, Rudolph Fredua-Agyeman, Brasathe Jeganathan, Lusine Tonoyan, Stephen E. Strelkov, Thava Vasanthan, Arno G. Siraki, M. S. Roopesh

Toxins. 2023 February; 10.3390/toxins15020124

Heating of consumer cannabis oils can lead to free radical initiated degradation, causing CBD and THC depletion

Lusine Tonoyan, Dinesh Babu, Bela Reiz, Tyson Le, Arno G. Siraki

Free Radical Biology and Medicine. 2022 November; 10.1016/j.freeradbiomed.2022.09.005

Treatment of a mixture of pharmaceuticals, herbicides and perfluorinated compounds by powdered activated carbon and ozone: Synergy, catalysis and insights into non-free OH contingent mechanisms

Mirna Alameddine, Arno Siraki, Lusine Tonoyan, Mohamed Gamal El-Din

Science of The Total Environment. 2021 July; 10.1016/j.scitotenv.2021.146138

Myeloperoxidase-mediated oxidation of edaravone produces an apparent non-toxic free radical metabolite and modulates hydrogen peroxide-mediated cytotoxicity in HL-60 cells

Lindsey Y.K. Suh, Dinesh Babu, Lusine Tonoyan, Béla Reiz, Randy Whittal, S. Amirhossein Tabatabaei-Dakhili, Andrew G. Morgan, Carlos A. Velázquez-Martínez, Arno G. Siraki

Free Radical Biology and Medicine. 2019 November; 10.1016/j.freeradbiomed.2019.08.021

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