Skeletal muscle contractions generate the forces that allow us to interact with our environment. The structural and functional characteristics of skeletal muscle fibres determine the nature and quality of those interactions. A post-mitotic tissue, skeletal muscle possesses considerable plasticity that allows it to dramatically change its structural and functional properties to meet new demands placed on it by the external environment. My research uses a rodent model of muscle training (chronic low-frequency electrical stimulation - CLFS) that converts fast contracting (fast-twitch) muscle that fatigues rapidly into a slower contracting, fatigue resistant phenotype. This model forms the primary experimental basis to investigate the mechanistic underpinnings of skeletal muscle plasticity in vivo. Current studies focus on determining: (1) how calcineurin signalling directs CLFS-induced fast-to-slow fibre type transitions; (2) the contributions of muscle progenitor cell populations in directing fast-to-slow fibre type transitions.
• Senior undergraduate course in Human Gross Anatomy (KIN 400)
• Graduate course in Biochemistry Laboratory Techniques (KIN 517)
• Currently provides supervision to several graduate students.
• Dr. Putman is available to supervise 2 additional graduate students and is now accepting applications.
Dr. Putman is available to supervise 2 additional graduate students and is now accepting applications.