Trevor Steve

Area of Study / Keywords

in vivo MRI ex vivo MRI

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About

I completed my MD at the University of Saskatchewan in 2008.  I subsequently undertook my Neurology Residency training at the University of Alberta and obtained my FRCPC in 2015.  Following this, I completed a 1-year fellowship in Epilepsy and electroencephalography at the University of Alberta.  I completed a PhD in experimental medicine in 2018.  I am currently an Assistant Professor in the Division of Neurology, Department of Medicine at the University of Alberta. My clinical interests are in general neurology, urgent neurology, Epilepsy and electroencephalography. 

Clinical Interests

Temporal Lobe Epilepsy, drug resistant epilepsy, surface EEG, stereo-encephalography (depth electrode recordings), epilepsy surgery

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Research

I am currently recruiting MSc and PhD students.  

My research focuses on brain mapping, the process by which specific brain regions are distinguished from each other.  In particular, I am interested in cytoarchitectural and myeloarchitectural definitions of brain regions - and how these can be applied to MRI.  The methodology I current employ involves coregistration of ex vivo MRI with histology.  We have published an initial proof-of-concept study using this method: 

Steve TA, Yasuda CL, Coras R, Lail M, Blumcke I, Livy DJ, Malykhin N, Gross DW. Development of a histologically validated segmentation protocol for the hippocampal body NeuroImage 2017;157:219-232

Our current project aims to expand this work to include the remainder of the temporal lobe and to apply this in patients with neurological disorders.  Our work is translational as we design tools which are applicable to in vivo MRI.  We have active projects in which we apply our techniques in patients with temporal lobe epilepsy. The primary clinical purpose of this application is the prediction of outcomes from epilepsy surgery. We are also actively developing potential MRI-based biomarkers for Alzheimer's Disease using the ADNI database.  

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Teaching

I am currently the course coordinator for Off-Service Residents rotating through the Neurology service at the University of Alberta. I also lecture on a number of topics throughout the year, especially on seizures and epilepsy.  

Spring A.M., Pittman D.J., Rizwan A., Aghakhani Y., Jirsch J., Connolly M., Wiebe S., Appendino J.P., Datta A., Steve T., Pillay N., Javidan M., Scantlebury M., Hrazdil C., Josephson C.B., Boelman C., Gross D., Singh S., Bello-Espinosa L., Huh L., Jetté N., Federico P.

Frontiers in Neurology. 2022 February; 13 10.3389/fneur.2022.794668