Frank van Landeghem, Dr med habil

Area of Study / Keywords

Biomedical research Neuro-Oncology Translational research Biomarkers Infectious diseases

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About

Since 2013, I'm working as Associate Professor of Neuropathology at the Division of Anatomical Pathology, Department of Laboratory Medicine & Pathology, University of Alberta.

Following graduation in 1993 from the University of Muenster in Germany, I was trained in Neuropathology at the Charite - University Medicine Berlin, Germany (1995 - 2001). From 2002 - 2008, I worked as neuropathologist at the Charite, as deputy chair with Andreas von Deimling and then as active chair in 2007-2008. From 2008 - 2012, I worked at the Dpt. of Neuropathology and the German Brain Tumor Reference Centre in Bonn, Germany.

My research interests focus on neuro-oncology and neuro-inflammation. I have received grants from the Alberta Cancer Foundation, University Hospital Foundation (Kaye Fund Competition 2018/19), University of Alberta, Deutsche Forschungsgemeinschaft' ('German Research Society'; DFG), and ZNS - Hannelore Kohl Stiftung ('CNS - Hannelore Kohl Foundation'). I published more than 90 papers in peer-reviewed journals.

Doctoral Thesis (Dr. med.):

 Title: "Macromorphological and histological findings of the larynx in sudden and unexpected infant death", mentor: Prof. Dr. med. B. Brinkmann, Legal Medicine, Westfaelische Wilhelms-Universitaet Muenster, Germany.

Habilitation: 

Title: "Glutamate transport in the CNS - examinations following traumatic brain injury and transient global ischemia", mentor: Prof. Dr. med. A. von Deimling, Neuropathology, Charite, Berlin, Germany.

Selected publications:

• Pellegrino N, Ecclestone BR, Dinakaran D, van Landeghem F, Fieguth P, Haji Reza P. Time-domain feature extraction for target specificity in photoacoustic remote sensing microscopy. Opt Lett. 2022 Aug 1;47(15):3952-3955. doi: 10.1364/OL.457142.
• Federico A, et al, Hasselblatt M. ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance. Acta Neuropathol. 2022 Jun;143(6):697-711. doi: 10.1007/s00401-022-02424-5.
• Doan MAL, Roczkowsky A, Smith M, Blevins G, van Landeghem FKH, Gelman BB, Branton WG, Stapleton JT, Hobman TC, Power C. Infection of glia by human pegivirus suppresses peroxisomal and antiviral signaling pathways. J Virol. 2021 Nov 9;95(23):e0107421. doi: 10.1128/JVI.01074-21.
• Khan S, et al, Huang A. Clinical phenotypes and prognostic features of embryonal tumours with multi-layered rosettes: a Rare Brain Tumor Registry study. Lancet Child Adolesc Health. 2021 Nov;5(11):800-813. doi: 10.1016/S2352-4642(21)00245-5.
• Nobre L, et al, Tabori U.  Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020 May 20;4:PO.19.00298. doi: 10.1200/PO.19.00298.
• Guerreiro Stucklin AS, et al, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25;10(1):4343. doi: 10.1038/s41467-019-12187-5. 
• Lau D, Cooper R, Chen J, Sim VL, McCombe JA, Tyrrell GJ, Bhargava R, Adam B, Chapman E, Croxen MA, Garady C, Antonation K, van Landeghem FKH, Ip S, Saxinger L. Mycobacterium chimaera encephalitis post-cardiac surgery: A new syndrome. Clin Infect Dis. 2019 Jun 18. pii: ciz497. doi: 10.1093/cid/ciz497.

PubMed:

https://www.ncbi.nlm.nih.gov/pubmed/?term=van+Landeghem+F

CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE. 2022 August; 10.1016/j.jcjo.2022.07.004

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Pellegrino N., Ecclestone B.R., Dinakaran D., van Landeghem F., Fieguth P., Reza P.H.

OPTICS LETTERS. 2022 August; 47 (15):3952-3955 10.1364/OL.457142

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Steed T., Indelicato D.J., Souster J., van Landeghem F.K.H., Mehta V., Patel S.

CHILDS NERVOUS SYSTEM. 2022 July; 10.1007/s00381-022-05604-6

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Federico A., Thomas C., Miskiewicz K., Woltering N., Zin F., Nemes K., Bison B., Johann P.D., Hawes D., Bens S., Kordes U., Albrecht S., Dohmen H., Hauser P., Keyvani K., van Landeghem F.K.H., Lund E.L., Scheie D., Mawrin C., Monoranu C.M., Parm Ulhøi B., Pietsch T., Reinhard H., Riemenschneider M.J., Sehested A., Sumerauer D., Siebert R., Paulus W., Frühwald M.C., Kool M., Hasselblatt M.

ACTA NEUROPATHOLOGICA. 2022 June; 143 (6):697-711 10.1007/s00401-022-02424-5

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Doan M.A.L., Roczkowsky A., Smith M., Blevins G., van Landeghem F.K.H., Gelman B.B., Branton W.G., Stapleton J.T., Hobman T.C., Power C.

JOURNAL OF VIROLOGY. 2021 December; 95 (23) 10.1128/JVI.01074-21

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Khan S., Solano-Paez P., Suwal T., Lu M., Al-Karmi S., Ho B., Mumal I., Shago M., Hoffman L.M., Dodgshun A., Nobusawa S., Tabori U., Bartels U., Ziegler D.S., Hansford J.R., Ramaswamy V., Hawkins C., Dufour C., André N., Bouffet E., Huang A., Gonzalez CV A., Stephens D., Leary S., Marrano P., Fonseca A., Thacker N., Li B.K., Lindsay H.B., Lassaletta A., Bendel A.E., Moertel C., Morales La Madrid A., Santa-Maria V., Lavarino C., Rivas E., Perreault S., Ellezam B., Weil A.G., Jabado N., Oviedo A., Yalon-Oren M., Amariglio L., Toledano H., Dvir R., Loukides J., Van Meter T.E., Nakamura H., Wong T.T., Wu K.S., Cheng C.J., Ra Y.S., La Spina M., Massimi L., Buccoliero A.M., Reddy A., Li R., Gillespie G.Y., Adamek D., Fangusaro J., Scharnhorst D., Torkildson J., Johnston D., Michaud J., LafayCousin L., Chan J., Van Landeghem F., Wilson B., Camelo-Piragua S., Kabbara N., Boutarbouch M., Hanson D., Jacobsen C., Wright K., Vibhakar R., Levy J.M., Wang Y., Catchpoole D., Gerber N., Grotzer M.A., Shen V., Plant A., Dunham C., Joao Gil da Costa M., Ramanujachar R., Raabe E., Rubens J., Phillips J., Gupta N., Demir H.A., Dahl C., Jorgensen M., Hwang E.I., Packer R.J., Smith A., Tan E., Low S., Lu J.Q., Ng H.K., Kresak J.L., Gururangan S., Pomeroy S.L., Sirachainan N., Hongeng S., Magimairajan V., Sinha R., Mushtaq N., Antony R., Sato M., Samuel D., Zapotocky M., Afzal S., Walter A., Tihan T., Tsang D.S., Gajjar A., Wood P., Cain J.E., Downie P.A., Gottardo N., Branson H., Laughlin S., Ertl-Wagner B., Kulkarni A.V., Taylor M.D., Drake J., Ibrahim G.M., Dirks P.B., Rutka J.T., Somers G.R., Hazrati L.N., Bourdeaut F., Padovani L., Grundy R.G., Mazewski C.M., Fouladi M.

Lancet Child & Adolescent Health. 2021 November; 5 (11):800-813 10.1016/S2352-4642(21)00245-5

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Nakano-Tateno T., Satou M., Inoshita N., van Landeghem F.K.H., Easaw J., Mehta V., Tateno T., Chik C.L.

ENDOCRINE PATHOLOGY. 2021 September; 32 (3):418-426 10.1007/s12022-020-09647-w

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6th Pediatric Neuro-Oncology Basic and Translational Research Conference, Society for NeuroOncology. 2021 June; 10.1093/neuonc/noab090.176

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Chik C.L., van Landeghem F.K.H., Easaw J.C., Mehta V.

J Endocr Soc. 2021 May; 5 (5):bvab043 10.1210/jendso/bvab043

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Kalisvaart A.C.J., Wilkinson C.M., Gu S., Kung T.F.C., Yager J., Winship I.R., van Landeghem F.K.H., Colbourne F.

Scientific Reports. 2020 December; 10 (1):22013 10.1038/s41598-020-78880-4

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Ecclestone B.R., Bell K., Abbasi S., Dinakaran D., van Landeghem F.K.H., Mackey J.R., Fieguth P., Haji Reza P.

Scientific Reports. 2020 December; 10 (1) 10.1038/s41598-020-74160-3

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Bell K., Abbasi S., Dinakaran D., Taher M., Bigras G., van Landeghem F.K.H., Mackey J.R., Haji Reza P.

Scientific Reports. 2020 December; 10 (1) 10.1038/s41598-020-76155-6