Frank Wuest

Area of Study / Keywords

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About

The Dianne and Irving Kipnes Chair in Radiopharmaceutical Sciences
AHFMR Senior Scholar

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Research

My research is embedded in the multidisciplinary field of translational cancer research. Research efforts are mainly aimed at the evaluation and translation of the diagnostic and therapeutic potential of novel molecular targets involved in the development and progression of cancer by means of molecular imaging techniques to enhance patient care.

This includes (1) the design, synthesis and characterization of novel molecular probes (radiotracers), (2) the assessment and characterization of novel molecular targets, and (3) the application of novel technologies for molecular imaging and therapy of cancer.

BIOCH 410 - Signal Transduction

Principles of the biochemistry of cell communication and signal transduction through receptor activation, generation of second messengers, control of protein modifications and regulation of the cell cycle. The course emphasizes mechanisms responsible for the regulation of cell migration, division and death with an emphasis on cancer. Prerequisites: BIOCH 310, 320 and 330, all with a minimum grade of B-, or consent of the Department. This course is intended for students in Honors or Specialization in Biochemistry. Students in other programs may be admitted subject to availability and with the consent of the Department. Graduate students may not register for credit (see BIOCH 510).

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BIOCH 510 - Signal Transduction

Principles of the biochemistry of cell communication and signal transduction through receptor activation, generation of second messengers, control of protein modifications and regulation of the cell cycle. The course emphasizes mechanisms responsible for the regulation of cell migration, division and death with an emphasis on cancer. Prerequisites: BIOCH 310, 320 and 330, all with a minimum grade of B-, or consent of the Department. Lectures are the same as for BIOCH 410, but with additional assignments and evaluation appropriate to graduate studies. This course may not be taken for credit if credit has already been obtained in BIOCH 410.

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ONCOL 520 - Tumor Biology

The course will provide an introduction to the basic science of oncology. Topics to be covered comprise: the genetic basis of cancer, including the role of proto-oncogenes and tumor suppressor genes; mechanisms of carcinogenesis and radiation-sensitivity, including DNA repair and cell cycle control; the molecular basis of tumor metastasis, including tumor cell invasion, extravasation and dormancy; the role of inflammation in cancer initiation and progression; angiogenesis; cancer genetics, and epigenetics; cell signaling; experimental therapeutics; cancer stem cells; drug-resistance; metabolism and palliation. Course offered in alternate (even-numbered) years. Prerequisites: BIOCH 200, and one of the following: BIOCH 320 or 330 or ONCOL 320.

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Browse more courses taught by Frank Wuest

Nario A.P., Woodfield J., dos Santos S.N., Bergman C., Wuest M., Araújo Y.B., Lapolli A.L., West F.G., Wuest F., Bernardes E.S.

EJNMMI Research. 2022 June; 7 (1) 10.1186/s41181-022-00165-0

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Kaur J., Bhardwaj A., Wuest F.

MOLECULES. 2022 June; 27 (12) 10.3390/molecules27123722

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Nelson B.J.B., Ferguson S., Wuest M., Wilson J., Duke M.J.M., Richter S., Soenke-Jans H., Andersson J.D., Juengling F., Wuest F.

JOURNAL OF NUCLEAR MEDICINE. 2022 April; 63 (4):584-590 10.2967/jnumed.121.262459

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Nelson B.J.B., Andersson J.D., Wuest F.

NUCLEAR MEDICINE AND BIOLOGY. 2022 April; 110-111 10.1016/j.nucmedbio.2022.04.005

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Rana N., Aziz M.A., Oraby A.K., Wuest M., Dufour J., Abouzid K.A.M., Wuest F., West F.G.

Pharmaceutics. 2022 April; 14 (4) 10.3390/pharmaceutics14040828

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Yuen R., West F.G., Wuest F.

Pharmaceutics. 2022 March; 14 (3) 10.3390/pharmaceutics14030645

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Francis F., Wuest F.

MOLECULES. 2021 October; 26 (21) 10.3390/molecules26216478

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Pérez D.J., Amirhossein Tabatabaei Dakhili S., Bergman C., Dufour J., Wuest M., Juengling F.D., Wuest F., Velázquez-Martínez C.A.

ChemMedChem. 2021 October; 16 (24):3720-3729 10.1002/cmdc.202100279

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Bailey J.J., Wuest M., Wagner M., Bhardwaj A., Wängler C., Wängler B., Valliant J.F., Schirrmacher R., Wuest F.

JOURNAL OF MEDICINAL CHEMISTRY. 2021 October; 64 (21):15671-15689 10.1021/acs.jmedchem.1c00812

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Dawn Woodfield J., Bhardwaj A., Bergman C., Wuest F.

ChemMedChem. 2021 October; 17 (1) 10.1002/cmdc.202100544

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Litchfield M., Wuest M., Glubrecht D., Briard E., Auberson Y.P., Mcmullen T.P.W., Brindley D.N., Wuest F.

MOLECULAR PHARMACEUTICS. 2021 September; 18 (9):3352-3364 10.1021/acs.molpharmaceut.1c00265

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Bailey J.J., Wuest M., Bojovic T., Kronemann T., Wängler C., Wängler B., Wuest F., Schirrmacher R.

ACS Omega. 2021 August; 6 (33):21741-21754 10.1021/acsomega.1c03315

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Juengling FD, Maldonado A, Wuest F, Schindler TH

Frontiers in Immunology. 2021 May; 12 10.3389/fimmu.2021.568959

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ACS Medicinal Chemistry Letters. 2021 April; 12 (5):798-804 10.1021/acsmedchemlett.1c00065

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Yuen R., Wagner M., Richter S., Dufour J., Wuest M., West F.G., Wuest F.

ORGANIC & BIOMOLECULAR CHEMISTRY. 2021 March; 19 (14):3241-3254 10.1039/d1ob00199j

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Ekanayake A.I., Sobze L., Kelich P., Youk J., Bennett N.J., Mukherjee R., Bhardwaj A., Wuest F., Vukovic L., Derda R.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2021 March; 143 (14):5497-5507 10.1021/jacs.1c01186

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Vahedpour T., Kaur J., Hemmati S., Hamzeh-Mivehroud M., Alizadeh A.A., Wuest F., Dastmalchi S.

CHEMISTRY & BIODIVERSITY. 2021 February; 18 (3) 10.1002/cbdv.202000832

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Ferguson S., Wuest M., Richter S., Bergman C., Dufour J., Krys D., Simone J., Jans H.S., Riauka T., Wuest F.

NUCLEAR MEDICINE AND BIOLOGY. 2020 December; 90-91 10.1016/j.nucmedbio.2020.10.005

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Nelson B.J.B., Wilson J., Andersson J.D., Wuest F.

Scientific Reports. 2020 December; 10 (1) 10.1038/s41598-020-79198-x

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Kaur J., Bhardwaj A., Wuest F.

CHEMISTRY-A EUROPEAN JOURNAL. 2020 December; 27 (10):3326-3337 10.1002/chem.202003315

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Krys D., Mattingly S., Glubrecht D., Wuest M., Wuest F.

MOLECULAR IMAGING AND BIOLOGY. 2020 December; 22 (6):1562-1571 10.1007/s11307-020-01529-1

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Nelson B.J.B., Andersson J.D., Wuest F.

Pharmaceutics. 2020 December; 13 (1):1-28 10.3390/pharmaceutics13010049

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Kedarisetti P., Bouvet V.R., Wei S.H.I., Bergman C.N., Dufour J., Ilkhechi A.K., Bell K.L., Paproski R.J., Lewis J.D., Wuest F.R., Zemp R.J.

Biomedical Optics Express. 2020 October; 11 (11):6211-6230 10.1364/BOE.410527