Chris Le

Area of Study / Keywords

---

About

Dr. Chris Le is Distinguished University Professor and Director of Analytical and Environmental Toxicology Division in the Faculty of Medicine & Dentistry, University of Alberta.

Degrees:

PhD (1993), Chemistry, University of British Columbia

MSc (1988), Chemistry, Brock University

MSc (1986), Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences

BSc (1979), Chemistry, Wuhan University.

Major awards:

University Cup. University of Alberta. 2018

FoMD Canada 150 Research Chair. Faculty of Medicine & Dentistry, University of Alberta. 2018

Fellow of the Royal Society of Chemistry (UK). 2016

BCEIA Outstanding Contribution Award. BCEIA Conference. 2015

Distinguished University Professor. University of Alberta. 2011

Maxxam Award (Analytical Chemistry). Canadian Society for Chemistry. 2011

Environment Research & Development Award. Chemical Institute of Canada. 2011

Fellow of the Royal Society of Canada (FRSC), Academy of Science. 2010

Canada Research Chair (Tier 1) in Bioanalytical Technology and Environmental Health. 2010-2017

Award for Excellence in Mentoring. Faculty of Medicine & Dentistry, University of Alberta. 2009

W.A.E. McBryde Medal. Canadian Society for Chemistry. 2002

Canada Research Chair (Tier 2) in Bioanalytical Technology and Environmental Health. 2001-2010

Fellow of the Chemical Institute of Canada (FCIC). 2001

Martha Cook Piper Research Prize. University of Alberta. 2000

E.W.R. Steacie Memorial Fellowship. Natural Sciences and Engineering Research Council. 2000

Editorship:

Analytical Chemistry (American Chemical Society). Since 2018

Environmental Health Perspectives (U. S. National Institute of Environmental Health Sciences). Since 2014

Journal of Environmental Sciences (Chinese Academy of Sciences and Elsevier). Since 2015

---

Research

1. Develop analytical techniques and assays for highly sensitive detection of environmental contaminants, nucleic acids, DNA mutation, and specific proteins.
2. Generate aptamers and improve affinity-binding and signal amplification techniques.
3. Design and construct nano-systems for cell imaging and drug delivery.
4. Assess human exposure to environmental contaminants and health effects.
5. Identify arsenic species in water, food, biological fluids and tissues.
6. Study mechanism(s) of arsenic metabolism and health effects.

---

Teaching

Dr. Le teaches LABMP550 (Analytical and Environmental Toxicology) and LABMP553 (Advanced Environmental Toxicology), and contributes to teaching LABMP551 (Laboratory Research Methods), LABMP530 (Experimental Design and Scientific Communication), and MLSCI466 (Applied Toxicology). He also gives guest lectures to several courses offered in other departments.  

Dr. Le mentors graduate students (MSc and PhD), undergraduate students (thesis and summer research), and post-doctoral fellows.

LABMP 550 - Analytical and Environmental Toxicology

Students will integrate knowledge and practical skills in the areas of environmental chemistry and toxicology. The student will learn to predict how chemicals can move and transform in the environment based on physical and chemical properties, how this affects human and environmental exposure, and consequences thereof for health. The basic principles of toxicology will be taught and students will gain appreciation for the diversity of physiological and/or biochemical mechanisms by which toxicants cause their adverse effects, and the various defenses our bodies have evolved to employ. Open to graduate students in Laboratory Medicine and Pathology. Students from other departments may register with consent of the instructor.

---

LABMP 561 - Advanced Mass Spectrometry

Topics covered will include advanced mass spectrometry principles, sample preparation instrument maintenance, quality control, and data analysis. Qualitative, quantitative and clinical applications of mass spectrometry will be covered. Emphasis on the use/applications mass spectrometry in clinical environments. This course is designed for graduate students. Credit may only be obtained in one of MLSCI 461 or LABMP 561.

---

MLSCI 461 - Advanced Mass Spectrometry

Topics covered will include advanced mass spectrometry principles, sample preparation instrument maintenance, quality control, and data analysis. Qualitative, quantitative and clinical applications of mass spectrometry will be covered. Emphasis on the use/applications mass spectrometry in clinical environments. This course is designed for senior undergraduate students. Credit may only be obtained in one of MLSCI 461 or LABMP 561.

---

Browse more courses taught by Chris Le

Liu Y, Kumblathan T, Feng W, Pang B, Tao J, Xu J, Xiao H, Joyce MA, Tyrrell DL, Zhang H. Li X-F, Le XC

ACS Measurement Science Au. 2022 June; 2 (3):224-232 10.1021/acsmeasuresciau.1c00057

---

Feng W, Xiao H, Yuan A, Deng Z, Wang X, Peng H, Le XC

Scientia Sinica Chimica . 2022 June; 52 10.1360/SSC-2022-0076

---

MacDonald A.M., Gabos S., Braakman S., Cheperdak L., Lee B., Hrudey S.E., Le X.C., Li X.F., Mandal R., Martin J.W., Schopflocher D., Lyon M.E., Cheung P.Y., Ackah F., Graydon J.A., Reichert M., Lyon A.W., Jarrell J., Benadé G., Charlton C., Huang D., Bennett M.J., Kinniburgh D.W.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH. 2022 May; 244 10.1016/j.ijheh.2022.113990

---

Li Q., Yao J., Jiang Y., Guo X., Ying Y., Wen Y., Liu X., Wu Y., Yang H., Le X.C.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY. 2022 May; 917 10.1016/j.jelechem.2022.116412

---

Zhou J.R., Kaur G., Ma Y., Arutyunov D., Lu X., Le X.C., Leslie E.M.

BIOCHEMICAL PHARMACOLOGY. 2021 November; 193 10.1016/j.bcp.2021.114799

---

Cao Y., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2021 November; 93 (47):15712-15719 10.1021/acs.analchem.1c03617

---

Tang Y., Gao L., Feng W., Guo C., Yang Q., Li F., Le X.C.

CHEMICAL SOCIETY REVIEWS. 2021 November; 50 (21):11844-11869 10.1039/d1cs00098e

---

Feng W., Peng H., Xu J., Liu Y., Pabbaraju K., Tipples G., Joyce M.A., Saffran H.A., Tyrrell D.L., Babiuk S., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2021 September; 93 (37):12808-12816 10.1021/acs.analchem.1c03456

---

Le C., Liu Y., López-Orozco J., Joyce M.A., Le X.C., Tyrrell D.L.

ANALYTICAL CHEMISTRY. 2021 August; 93 (31):10756-10761 10.1021/acs.analchem.1c02227

---

Cao Y., Wu J., Pang B., Zhang H., Le X.C.

CHEMICAL COMMUNICATIONS. 2021 July; 57 (56):6871-6874 10.1039/d1cc02546e

---

Le C., Liu Y., López-Orozco J., Joyce M., Le X. C., Tyrrell D. L.

ANALYTICAL CHEMISTRY. 2021 July; 93 10.1021/acs.analchem.1c02227

---

Le X.C.

ANALYTICAL CHEMISTRY. 2021 June; 93 (24):8379-8380 10.1021/acs.analchem.1c02327

---

Cao Y., Wu J., Pang B., Zhang H., Le X.C.

CHEMICAL COMMUNICATIONS. 2021 June; 57 (56):6871-6874 10.1039/d1cc02546e

---

Qu X., Deng X., Pang Y., Wang W., Feng Y., Xu Z., Zhang Y., Le X.C.

Scientia Sinica Chimica. 2021 June; 51 (7):905-918 10.1360/SSC-2021-0025

---

Wu J., Peng H., Lu X., Lai M., Zhang H., Le X.C.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2021 May; 60 (20):11104-11109 10.1002/anie.202014162

---

Feng W., Newbigging A.M., Tao J., Cao Y., Peng H., Le C., Wu J., Pang B., Li J., Tyrrell D.L., Zhang H., Le X.C.

Chemical Science. 2021 April; 12 (13):4683-4698 10.1039/d0sc06973f

---

Liu Q., Huang C., Li W., Fang Z., Le X.C.

ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2021 March; 55 (6):3836-3844 10.1021/acs.est.0c07175

---

Li Z., Chen B., Li Y., Le X.C.

Journal of Environmental Sciences. 2021 February; 100 10.1016/j.jes.2020.11.002

---

Fu Z., Rais Y., Bismar T.A., Hyndman M.E., Le X.C., Drabovich A.P.

MOLECULAR & CELLULAR PROTEOMICS. 2021 January; 20 10.1016/J.MCPRO.2021.100075

---

Pang B., Xu J., Liu Y., Peng H., Feng W., Cao Y., Wu J., Xiao H., Pabbaraju K., Tipples G., Joyce M.A., Saffran H.A., Tyrrell D.L., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2020 December; 92 (24):16204-16212 10.1021/acs.analchem.0c04047

---

Davydiuk T., Chen X., Huang L., Shuai Q., Le X.C.

Journal of Environmental Sciences. 2020 November; 97 10.1016/j.jes.2020.08.012