Chris Le

About

Dr. Chris Le is Distinguished University Professor and Director of Analytical and Environmental Toxicology Division in the Faculty of Medicine & Dentistry, University of Alberta.

Degrees:

PhD (1993), Chemistry, University of British Columbia

MSc (1988), Chemistry, Brock University

MSc (1986), Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences

BSc (1979), Chemistry, Wuhan University.

Major awards:

University Cup. University of Alberta. 2018

FoMD Canada 150 Research Chair. Faculty of Medicine & Dentistry, University of Alberta. 2018

Fellow of the Royal Society of Chemistry (UK). 2016

BCEIA Outstanding Contribution Award. BCEIA Conference. 2015

Distinguished University Professor. University of Alberta. 2011

Maxxam Award (Analytical Chemistry). Canadian Society for Chemistry. 2011

Environment Research & Development Award. Chemical Institute of Canada. 2011

Fellow of the Royal Society of Canada (FRSC), Academy of Science. 2010

Canada Research Chair (Tier 1) in Bioanalytical Technology and Environmental Health. 2010-2017

Award for Excellence in Mentoring. Faculty of Medicine & Dentistry, University of Alberta. 2009

W.A.E. McBryde Medal. Canadian Society for Chemistry. 2002

Canada Research Chair (Tier 2) in Bioanalytical Technology and Environmental Health. 2001-2010

Fellow of the Chemical Institute of Canada (FCIC). 2001

Martha Cook Piper Research Prize. University of Alberta. 2000

E.W.R. Steacie Memorial Fellowship. Natural Sciences and Engineering Research Council. 2000

Editorship:

Analytical Chemistry (American Chemical Society). Since 2018

Environmental Health Perspectives (U. S. National Institute of Environmental Health Sciences). Since 2014

Journal of Environmental Sciences (Chinese Academy of Sciences and Elsevier). Since 2015

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Research

1. Develop analytical techniques and assays for highly sensitive detection of environmental contaminants, nucleic acids, DNA mutation, and specific proteins.
2. Generate aptamers and improve affinity-binding and signal amplification techniques.
3. Design and construct nano-systems for cell imaging and drug delivery.
4. Assess human exposure to environmental contaminants and health effects.
5. Identify arsenic species in water, food, biological fluids and tissues.
6. Study mechanism(s) of arsenic metabolism and health effects.

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Teaching

Dr. Le teaches LABMP550 (Analytical and Environmental Toxicology) and LABMP553 (Advanced Environmental Toxicology), and contributes to teaching LABMP551 (Laboratory Research Methods), LABMP530 (Experimental Design and Scientific Communication), and MLSCI466 (Applied Toxicology). He also gives guest lectures to several courses offered in other departments.  

Dr. Le mentors graduate students (MSc and PhD), undergraduate students (thesis and summer research), and post-doctoral fellows.

LABMP 550 - Analytical and Environmental Toxicology

Students will integrate knowledge and practical skills in the areas of environmental chemistry and toxicology. The student will learn to predict how chemicals can move and transform in the environment based on physical and chemical properties, how this affects human and environmental exposure, and consequences thereof for health. The basic principles of toxicology will be taught and students will gain appreciation for the diversity of physiological and/or biochemical mechanisms by which toxicants cause their adverse effects, and the various defenses our bodies have evolved to employ. Open to graduate students in Laboratory Medicine and Pathology. Students from other departments may register with consent of the instructor.

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LABMP 561 - Advanced Mass Spectrometry

Topics covered will include advanced mass spectrometry principles, sample preparation instrument maintenance, quality control, and data analysis. Qualitative, quantitative and clinical applications of mass spectrometry will be covered. Emphasis on the use/applications mass spectrometry in clinical environments. This course is designed for graduate students. Credit may only be obtained in one of MLSCI 461 or LABMP 561.

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MLSCI 461 - Advanced Mass Spectrometry

Topics covered will include advanced mass spectrometry principles, sample preparation instrument maintenance, quality control, and data analysis. Qualitative, quantitative and clinical applications of mass spectrometry will be covered. Emphasis on the use/applications mass spectrometry in clinical environments. This course is designed for senior undergraduate students. Credit may only be obtained in one of MLSCI 461 or LABMP 561.

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Browse more courses taught by Chris Le

Wei Feng, Hanyong Peng, Hongquan Zhang, Michael Weinfeld, X. Chris Le

Angewandte Chemie International Edition. 2024 April; 10.1002/anie.202404069

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Yang Zhao, Xinyue Zhao, Lewei Duan, Ruxue Hou, Yuxin Gu, Zhen Liu, Jianbin Chen, Feizhen Wu, Limin Yang, X. Chris Le, Qiuquan Wang, Xiaowen Yan

Journal of Medicinal Chemistry. 2024 April; 10.1021/acs.jmedchem.3c02076

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Jianyu Hu, Xiaowen Yan, X. Chris Le

Analytical and Bioanalytical Chemistry. 2024 January; 10.1007/s00216-023-05106-7

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Tetiana Davydiuk, Jeffrey Tao, Xiufen Lu, X. Chris Le

Environment & Health. 2023 September; 10.1021/envhealth.3c00090

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Jeffrey Tao, Hongquan Zhang, Michael Weinfeld, X. Chris Le

Analytical Chemistry. 2023 September; 10.1021/acs.analchem.3c02574

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Teresa Kumblathan, Yanming Liu, Xiaoli Pang, Steve E Hrudey, X. Chris Le, Xing-Fang Li

Environment & Health. 2023 August; 10.1021/envhealth.3c00089

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Yanming Liu, Teresa Kumblathan, Jeffrey Tao, Jingyang Xu, Wei Feng, Huyan Xiao, Jianyu Hu, Camille V. Huang, Yiping Wu, Hongquan Zhang, Xing-Fang Li, X. Chris Le

TrAC Trends in Analytical Chemistry. 2023 August; 10.1016/j.trac.2023.117107

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Teresa Kumblathan, Yanming Liu, Judy Qiu, Lilly Pang, Steve E. Hrudey, X. Chris Le, Xing-Fang Li

Journal of Environmental Sciences. 2023 August; 10.1016/j.jes.2022.10.006

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Chester Lau, X. Chris Le

Journal of Environmental Sciences. 2023 June; 10.1016/j.jes.2023.01.007

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Yanming Liu, Teresa Kumblathan, Michael A. Joyce, D. Lorne Tyrrell, Graham Tipples, Xiaoli Pang, Xing-Fang Li, X. Chris Le

ACS Measurement Science Au. 2023 April; 10.1021/acsmeasuresciau.3c00005

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Huyan Xiao, Jianyu Hu, Camille Huang, Wei Feng, Yanming Liu, Teresa Kumblathan, Jeffrey Tao, Jingyang Xu, X. Chris Le, Hongquan Zhang

TrAC Trends in Analytical Chemistry. 2023 April; 10.1016/j.trac.2023.117000

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Wei Feng, Hongquan Zhang, X. Chris Le

Analytical Chemistry. 2023 January; 10.1021/acs.analchem.2c04555

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Karen S Hoy, Tetiana Davydiuk, Xiaojian Chen, Chester Lau, Jordan R M Schofield, Xiufen Lu, Jennifer A Graydon, Ruth Mitchell, Megan Reichert, X. Chris Le

Food Quality and Safety. 2023 January; 10.1093/fqsafe/fyad032

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Wenchan Deng, Jing Yang Xu, Hanyong Peng, Cheng Zhi Huang, X. Chris Le, Hongquan Zhang

Biosensors and Bioelectronics. 2022 December; 10.1016/j.bios.2022.114704

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Maria C Moreno Bondi, X. Chris Le, Jennifer Field, Susan Richardson, Xing-Fang Li, Miriam L Diamond, Li Xiangdong; Li X.D.; Li XD; Li X-D; Li X-d; Li X., Paul Goring

Analytical Chemistry. 2022 October; 10.1021/acs.analchem.2c04534

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Wei Feng, Hang Xiao, Aijiao Yuan, Zhaojia Deng, Xiaoyan Wang, Hanyong Peng, X. Chris Le

SCIENTIA SINICA Chimica. 2022 September; 10.1360/ssc-2022-0076

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Amy MacDonald, Stephan Gabos, Sandy Braakman, Laurie Cheperdak, Bonita Lee, Steve E. Hrudey, X. Chris Le, Xing-Fang Li, Rupasri Mandal, Jonathan W. Martin, Don Schopflocher, Martha E. Lyon, Po-Yin Cheung, Fred Ackah, Jennifer Graydon, Megan Reichert, Andrew W. Lyon, John Jarrell, Gerhard Benadé, Carmen Charlton, Dorothy Yu Huang, Melissa J. Bennett, David W. Kinniburgh

International Journal of Hygiene and Environmental Health. 2022 July; 10.1016/j.ijheh.2022.113990

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Qi Li, Jingjing Yao, Yuning Jiang, Xiaoyu Guo, Ye Ying, Ying Wen, Xinling Liu, Yiping Wu, Haifeng Yang, X. Chris Le

Journal of Electroanalytical Chemistry. 2022 July; 10.1016/j.jelechem.2022.116412

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Yanming Liu, Teresa Kumblathan, Wei, Bo Pang, Jeffrey Tao, Jingyang Xu, Huyan Xiao, Michael A. Joyce, D. Lorne Tyrrell, Hongquan Zhang, Xing-Fang Li, X. Chris Le

ACS Measurement Science Au. 2022 February; 10.1021/acsmeasuresciau.1c00057

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Tang Y., Gao L., Feng W., Guo C., Yang Q., Li F., Le X.C.

CHEMICAL SOCIETY REVIEWS. 2021 November; 50 (21):11844-11869 10.1039/d1cs00098e

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Janet R. Zhou, Gurnit Kaur, Yingze Ma, Denis Arutyunov, Xiufen Lu, X. Chris Le, Elaine M. Leslie

Biochemical Pharmacology. 2021 November; 10.1016/j.bcp.2021.114799

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Cao Y., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2021 November; 93 (47):15712-15719 10.1021/acs.analchem.1c03617

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Feng W., Peng H., Xu J., Liu Y., Pabbaraju K., Tipples G., Joyce M.A., Saffran H.A., Tyrrell D.L., Babiuk S., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2021 September; 93 (37):12808-12816 10.1021/acs.analchem.1c03456

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Connie Le, Yanming Liu, Joaquín López-Orozco, Michael A. Joyce, X. Chris Le, D. Lorne Tyrrell

Analytical Chemistry. 2021 July; 10.1021/acs.analchem.1c02227

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Cao Y., Wu J., Pang B., Zhang H., Le X.C.

CHEMICAL COMMUNICATIONS. 2021 July; 57 (56):6871-6874 10.1039/d1cc02546e

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Xufang Qu, Xinyu Deng, Yuehong Pang, Wenlong Wang, Yongwei Feng, Zhenghua Xu, Yi Zhang, X. Chris Le

SCIENTIA SINICA Chimica. 2021 June; 10.1360/ssc-2021-0025

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Le X.C.

ANALYTICAL CHEMISTRY. 2021 June; 93 (24):8379-8380 10.1021/acs.analchem.1c02327

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Qu X., Deng X., Pang Y., Wang W., Feng Y., Xu Z., Zhang Y., Le X.C.

Scientia Sinica Chimica. 2021 June; 51 (7):905-918 10.1360/SSC-2021-0025

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Wu J., Peng H., Lu X., Lai M., Zhang H., Le X.C.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2021 May; 60 (20):11104-11109 10.1002/anie.202014162

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Feng W., Newbigging A.M., Tao J., Cao Y., Peng H., Le C., Wu J., Pang B., Li J., Tyrrell D.L., Zhang H., Le X.C.

Chemical Science. 2021 April; 12 (13):4683-4698 10.1039/d0sc06973f

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Liu Q., Huang C., Li W., Fang Z., Le X.C.

ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2021 March; 55 (6):3836-3844 10.1021/acs.est.0c07175

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Li Z., Chen B., Li Y., Le X.C.

Journal of Environmental Sciences. 2021 February; 100 10.1016/j.jes.2020.11.002

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Zhiqiang Fu, Yasmine Rais, Tarek A. Bismar, M. Eric Hyndman, X. Chris Le, Andrei P. Drabovich

Molecular & Cellular Proteomics. 2021 January; 10.1016/j.mcpro.2021.100075

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Liu, Q.Q.; Huang, C.Z.; Li, W.H.; Fang, Z.Z.; Le, X.C.

Environmental Science and Technology. 2021 January; 10.1021/acs.est.0c07175

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Cao, Y.; Wu, J.; Pang, B.; Zhang, H.; Le, X.C.

Chemical Science. 2021 January; 10.1039/d0sc06973f

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Analytical Chemistry. 2021 January; 10.1021/acs.analchem.1c02327

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Fu Z., Rais Y., Bismar T.A., Hyndman M.E., Le X.C., Drabovich A.P.

MOLECULAR & CELLULAR PROTEOMICS. 2021 January; 20 10.1016/J.MCPRO.2021.100075

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Yanan Tang, Lu Gao, Wei, Chen Guo, Qianfan Yang, Feng Li, X. Chris Le

Chemical Society Reviews. 2021 January; 10.1039/d1cs00098e

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Pang B., Xu J., Liu Y., Peng H., Feng W., Cao Y., Wu J., Xiao H., Pabbaraju K., Tipples G., Joyce M.A., Saffran H.A., Tyrrell D.L., Zhang H., Le X.C.

ANALYTICAL CHEMISTRY. 2020 December; 92 (24):16204-16212 10.1021/acs.analchem.0c04047

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Davydiuk T., Chen X., Huang L., Shuai Q., Le X.C.

Journal of Environmental Sciences. 2020 November; 97 10.1016/j.jes.2020.08.012

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Qingqing Liu, Chengzhi Huang, X. Chris Le

Journal of Environmental Sciences. 2020 May; 10.1016/j.jes.2020.01.023

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Peng, H.; Le, C.; Wu, J.; Li, X.-F.; Zhang, H.; Le, X.C.

ACS Nano. 2020 January; 10.1021/acsnano.9b05276

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Analytical Chemistry. 2020 January; 10.1021/acs.analchem.9b05740

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Analytica Chimica Acta. 2020 January; 10.1016/j.aca.2020.05.061

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TrAC - Trends in Analytical Chemistry. 2020 January; 10.1016/j.trac.2019.115770

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Journal of Environmental Sciences (China). 2020 January; 10.1016/j.jes.2020.03.004

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Analytical Chemistry. 2020 January; 10.1021/acs.analchem.0c04047

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bioRxiv. 2020 January; 10.1101/2020.09.23.309088

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Analytical Chemistry. 2020 January; 10.1021/acs.analchem.0c02060

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Applied and Environmental Microbiology. 2020 January; 10.1128/AEM.02050-19

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Journal of Environmental Sciences (China). 2020 January; 10.1016/j.jes.2020.08.012

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Analytical Chemistry. 2020 January; 10.1021/acs.analchem.9b04752

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Journal of Environmental Sciences (China). 2020 January; 10.1016/j.jes.2020.04.003

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Journal of Environmental Sciences (China). 2020 January; 10.1016/j.jes.2019.10.002

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