Stephanie Yanow, PhD

Professor, School of Public Health

Contact

Professor, School of Public Health
Email
yanow@ualberta.ca
Phone
(780) 248-1018
Address
6-032b Katz Group Centre For Research
11315 - 87 Ave NW
Edmonton AB
T6G 2H5

Overview

About

Education and Training

PhD in Cell Biology 1998 – 2001
Imperial Cancer Research Fund,
University College London, 
London, England

Bachelor of Science, First Class Honours 1992 – 1996
Department of Biology, 
McGill University, 
Montreal, Quebec, Canada

Postdoc training: McGill University (2004-2006), California Institute of Technology (2001-2003)

Awards:

  • 1998 – 2001 Overseas Research Studentship award, University College London
  • 1998 – 1999 British Council Chevening/Athlone-Vanier Fellowship
  • 1998 – 2000 Natural Sciences and Engineering Research Council of Canada post-graduate award
  • 2000 Promega UK Young Life Scientist of the Year
  • 2001 – 2003 Caltech Divisional Fellowship
  • 2004 – 2007 Fonds de Recherche en Santé du Québec Postdoctoral Fellowship; declined
  • 2004 – 2006 Richard H. Tomlinson postdoctoral fellowship, McGill University
  • 2004 – 2007 CIHR postdoctoral fellowship
  • 2011 Rising Stars in Global Health Award, Grand Challenges Canada
  • 2014 – 2016 Host, Visiting Scientist Award from Alberta Innovates – Health Solutions
  • 2014 Endeavour Executive Fellowship, Australia


Partnerships

Research collaborations within the University of Alberta:

  • Department of Biological Sciences, Canada
  • Department of Medical Microbiology & Immunology, Canada

Research collaborations with other academic institutions:

  • Griffith University, Australia
  • University of Antioquia, Colombia
  • FIOCRUZ, Brazil
  • NIRTH, India
  • University of Toronto, Canada
  • University of Copenhagen, Denmark
  • University of South Florida, USA

Collaborations with governmental organizations:

  • Ministry of Health, Uganda

Collaborations with industry:

  • Aquila Diagnostic Systems Inc., Canada

Research

My research program is focused on different aspects of malaria from basic pathogenesis to translational development of diagnostics and vaccines. My lab is engaged in a multidisciplinary collaboration to transfer molecular diagnostic tests for malaria to a platform to be used at the point-of-care in limited-resource areas. We have partnered with international colleagues to pilot this technology in malaria-endemic settings (Uganda, India). Another major focus of our work is on the interactions between malaria parasites of different species and the host immune response, particularly during infection in pregnancy. From our work with colleagues in Colombia and Brazil, we discovered that exposure to Plasmodium vivax may induce protective antibodies against P. falciparum in pregnancy, leading to improved birth outcomes. My team is now trying to understand this mechanism of cross-species immunity and exploit these findings for vaccine development. 

Courses

SPH 506 - Public Health Biology

Provides an understanding of the biology of human health and disease as it affects public health. Normal biochemistry, physiology and immunology of healthy humans. Exploration of mechanisms responsible for genetic, nutritional, infectious, toxic and chronic diseases and their effects on human populations. Factors affecting human health and disease during stages of human development including infancy, youth, reproduction, pregnancy and aging. Examine the basis for current health promotion, disease prevention and control strategies. Note: Credit may not be obtained for both PHS 506 and SPH 506.

Winter Term 2022
SPH 561 - Topics in Public Health

Winter Term 2022 Winter Term 2023
SPH 640 - Introduction to Global Health

The aim of this course is to enable students to increase their understanding of historical and current determinants of global health and of the interventions to reduce global health inequities. Note: Credit may not be obtained for both PHS 640 and SPH 640.

Fall Term 2021 Fall Term 2022

Browse more courses taught by Stephanie Yanow

Scholarly Activities

Research - Developing a cross-species malaria vaccine

We are mapping epitopes that can induce cross-reactive antibodies that recognize parasite antigens in different species of Plasmodium. These will be developed as candidate vaccines to protect pregnant women from malaria. 


Research - Development of a ‘Lab-on-a-Chip’ for malaria diagnosis

Our interdisciplinary team aims to transfer molecular diagnostic tests for malaria to platforms that can be used at the point-of-care in low resource settings. The technology is being commercialized in partnership with Aquila Diagnostic Systems Inc, Edmonton. Field trials of the technology are underway in India. We are also developing tests to detect SNPs associated with resistance to antimalarials and diagnostic tests for dengue.


Research - Integrated molecular approaches to the diagnosis and epidemiology of pregnancy-associated malaria in Latin America

We are applying molecular diagnostics to investigate the prevalence and parasite dynamics of P. falciparum and P. vivax during pregnancy within a low transmission setting in Colombia. We are also studying the effects of these infections on host immunity and clinical outcomes. (In collaboration with Dr. Amanda Maestre, Universidad de Antioquia, Colombia and Dr. Michael Good, Griffith University, Australia).

Publications

Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the region.
Author(s): Rajwani J, Klinger CM, Arango E, Arroyo MI, Sabbagh A, Maestre A, Dacks JB, Gnidehou S, Yanow SK.
Publication Date: 2017
Publication: Infection Genetics and Evolution
Volume: 55
Page Numbers: 175-185
External Link: https://www.ncbi.nlm.nih.gov/pubmed/28893687
A Direct from Blood Reverse Transcriptase Polymerase Chain Reaction Assay for Monitoring Falciparum Malaria Parasite Transmission in Elimination Settings.
Author(s): Taylor BJ, Lanke K, Banman SL, Morlais I, Morin MJ, Bousema T, Rijpma SR, Yanow SK.
Publication Date: 2017
Publication: American Journal of Tropical Medicine and Hygiene
Volume: 97
Page Numbers: 533-543
External Link: https://www.ncbi.nlm.nih.gov/pubmed/28722583
A sensitive species-specific reverse transcription real-time PCR method for detection of Plasmodium falciparum and Plasmodium vivax.
Author(s): Gavina, K., Arango, E., Larrotta, C.A., Maestre, A., Yanow, S.K.
Publication Date: 2017
Publication: Parasite Epidemiology and Control

Impact of Malaria in Pregnancy as Latin America Approaches Elimination.
Author(s): Yanow SK, Gavina K, Gnidehou S, Maestre A.
Publication Date: 2016
Publication: Trends in Parasitology
Volume: 32
Page Numbers: 416-27

Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA.
Author(s): Gnidehou S, Mitran CJ, Arango E, Banman S, Mena A, Medawar E, Lima BAS, Doritchamou J, Rajwani J, Jin A, Gavina K, Ntumngia F, Duffy P, Narum D, Ndam NT, Nielsen MA, Salanti A, Kano FS, Carvalho LH, Adams JH, Maestre A, Good MF, Yanow SK.
Publication: The Journal of Infectious Diseases
Volume: 219
Issue: 1
Page Numbers: 110-120

Functional antibodies against VAR2CSA in non-pregnant populations from Colombia exposed to Plasmodium falciparum and Plasmodium vivax.
Author(s): 4. Gnidehou, S., Doritchamou, J., Arango, E.M., Cabrera, A., Arroyo, M.I., Kain, K.C., Ndam, N., Maestre, A., and Yanow, S.K.
Publication: Infection and Immunity
Volume: 82
Page Numbers: 2565

A Lab-on-Chip for malaria diagnosis and surveillance.
Author(s): 3. Taylor, B.J., Howell, A., Martin, K.A., Manage, D.P., Gordy, W., Campbell, S.D., Lam, S., Jin, A., Polley, S.D., Samuel, R.A., Atrazhev, A., Stickel, A.J., Birungi, J., Mbonye, A.K., Pilarski, L.M., Acker, J.P., and Yanow, S.K.
Publication: Malaria Journal
Volume: 13
Page Numbers: 179

Molecular detection of malaria at delivery reveals a high frequency of submicroscopic infections and associated placental damage in pregnant women from Northwest Colombia
Author(s): 8. Arango, E.M., Samuel, R., Agudelo, O.M., Carmona-Fonseca, J., Maestre, A., and Yanow, S.K.
Publication: The American Journal of Tropical Medicine and Hygiene
Volume: 89
Page Numbers: 178