Stephanie Yanow, PhD

Area of Study / Keywords

Malaria pregnancy vaccines diagnostics

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About

Stephanie Yanow is currently appointed as Adjunct Professor in the Department of Medical Microbiology & Immunology in the Faculty of Medicine & Dentistry.

SPH 640 - Introduction to Global Health

The aim of this course is to enable students to increase their understanding of historical and current determinants of global health and of the interventions to reduce global health inequities. Note: Credit may not be obtained for both PHS 640 and SPH 640.

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The goal of this project is to exploit natural cross-immunity between P. vivax and P. falciparum antigens that we observed in Colombia and Brazil to develop a vaccine against P. falciparum placental malaria. We are mapping the epitopes that induce cross-reactive antibodies and employing synthetic chemistry, structural biology, and computational modeling strategies to design vaccine candidates. We test different vaccine platforms (subunit vaccines and peptide- decorated liposomes) along with various adjuvant formulations to optimize vaccine responses.  Collaborators: John Adams, University of South Florida; Eliana Arango and Amanda Maestre, U de Antioquia, Colombia; Michael Good, Griffith University, Australia.

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We study the effects of parasite cytoadhesion on the physiology of the placenta. We are interested in the proteoglycan receptors that bind to infected red blood cells in the placenta and how they are regulated during infection.  We also collaborate on studies of parasite extracellular vesicles in placental malaria.  Collaborators: Denise Hemmings, Lara Mahal,  and Lisa Willis, U of Alberta; Eliana Arango and Amanda Maestre, U de Antioquia, Colombia; Melisa Gualdrón-López, McGill University; Hernando del Portillo and Carmen Fernandez at ISGlobal, Barcelona; Bernard Kanoi, Mount Kenya University.

Stephanie K Yanow 1, Daniel Ferrer Vinals 2

Lancet Infectious Diseases. 2024 July; 10.1016/S1473-3099(24)00405-5

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Michael F Good 1, Stephanie K Yanow 2

Trends in Parasitology. 2023 November; 10.1016/j.pt.2023.08.006

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Anna Maria van Eijk 1, Kasia Stepniewska 2, Jenny Hill 3, Steve M Taylor 4, Stephen J Rogerson 5, Gilles Cottrell 6, R Matthew Chico 7, Julie R Gutman 8, Halidou Tinto 9, Holger W Unger 10, Stephanie K Yanow 11, Steven R Meshnick 12, Feiko O Ter Kuile 3, Alfredo Mayor 13; Subpatent Malaria in Pregnancy Group

Lancet Global Health. 2023 July; 10.1016/S2214-109X(23)00194-8

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Uwa Iyamu 1, Daniel Ferrer Vinals 1, Bernard Tornyigah 1, Eliana Arango 2 3, Rakesh Bhat 4, Trixie Rae Adra 4, Simranjit Grewal 5, Kimberly Martin 1, Amanda Maestre 2, Michael Overduin 4, Bart Hazes 5, Stephanie K Yanow 1 5

Front Cell Infect Microbiol . 2023 June; 10.3389/fcimb.2023.1202276

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Mitran, C.J., Higa, L., Good, M.F., and Yanow, S.K.

Vaccines. 2020 January; 8 (3) 10.3390/vaccines8030392

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Gnidehou, S., and Yanow, S.K.

Trends in Parasitology. 2020 January; 10.1016/j.pt.2020.09.012

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Mitran, C.J., Mena, A., Gnidehou, S., Banman, S., Arango, E., Lima, B.A.S., Lugo, H., Ganesan, A., Salanti, A., Mbonye, A.K., Ntumngia, F., Barakat, K., Adams, J.H., Kano, F.S., Carvalho, L.H., Maestre, A., Good, M.F., and Yanow, S.K.

mBio. 2020 January; 10.1128/mBio.02343-19

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Mitran, C.J., and Yanow, S.K.

Frontiers in Immunology. 2020 January; 11 (335)

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Gnidehou S, Mitran CJ, Arango E, Banman S, Mena A, Medawar E, Lima BAS, Doritchamou J, Rajwani J, Jin A, Gavina K, Ntumngia F, Duffy P, Narum D, Ndam NT, Nielsen MA, Salanti A, Kano FS, Carvalho LH, Adams JH, Maestre A, Good MF, Yanow SK.

The Journal of Infectious Diseases. 2019 January; 219 (1):110-120

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