Stephanie Yanow, PhD
Area of Study / Keywords
AboutStephanie Yanow is currently appointed as Assistant Adjunct Professor in the Department of Medical Microbiology & Immunology in the Faculty of Medicine & Dentistry.
Provides an understanding of the biology of human health and disease as it affects public health. Normal biochemistry, physiology and immunology of healthy humans. Exploration of mechanisms responsible for genetic, nutritional, infectious, toxic and chronic diseases and their effects on human populations. Factors affecting human health and disease during stages of human development including infancy, youth, reproduction, pregnancy and aging. Examine the basis for current health promotion, disease prevention and control strategies. Note: Credit may not be obtained for both PHS 506 and SPH 506.
Research - Developing a cross-species malaria vaccine
The goal of this project is to exploit natural cross-immunity between P. vivax and P. falciparum antigens that we observed in Colombia and Brazil to develop a vaccine against P. falciparum placental malaria. We are mapping the epitopes that induce cross-reactive antibodies and employing synthetic chemistry, structural biology, and computational modeling strategies to design vaccine candidates. Collaborators: Dr. John Adams, University of South Florida; Dr. Eliana Arango and Dr. Amanda Maestre, U de Antioquia, Colombia; Dr. Michael Good, Griffith University, Australia.
Research - Integrated molecular approaches to the diagnosis and epidemiology of pregnancy-associated malaria in Latin America
We apply molecular diagnostics to investigate the prevalence and parasite dynamics of P. falciparum and P. vivax during pregnancy within a low transmission setting in Colombia. We recently completed a longitudinal study of pregnant women in Colombia and are studying the effects of infections in pregnancy on host immunity and clinical outcomes at delivery. We are particularly interested in how submicroscopic infections are controlled by maternal immunity. Collaborators: Dr. Eliana Arango and Dr. Amanda Maestre, U de Antioquia, Colombia.
Research - Pathogenesis of placental malaria (Project co-lead)
We are developing an ex-vivo model of placental malaria using placental villi and cultured P. falciparum parasites. With this model, we are studying the effects of parasite cytoadhesion on the physiology of the placenta, the role of host and parasite exosomes on cytoadhesion and immune cell recruitment, and the regulation of the syndecan-1 receptor. We are also using this model for pre-clinical testing of antibodies raised against our vaccine candidates. Collaborators: Dr. Denise Hemmings, U of Alberta; Dr. Hernando del Portillo and Dr. Carmen Fernandez at ISGlobal, Barcelona.
Mitran, C.J., Higa, L., Good, M.F., and Yanow, S.K.
Vaccines. 2020 January; 8 (3) 10.3390/vaccines8030392
Gnidehou, S., and Yanow, S.K.
Trends in Parasitology. 2020 January; 10.1016/j.pt.2020.09.012
Mitran, C.J., Mena, A., Gnidehou, S., Banman, S., Arango, E., Lima, B.A.S., Lugo, H., Ganesan, A., Salanti, A., Mbonye, A.K., Ntumngia, F., Barakat, K., Adams, J.H., Kano, F.S., Carvalho, L.H., Maestre, A., Good, M.F., and Yanow, S.K.
mBio. 2020 January; 10.1128/mBio.02343-19
The case for exploiting cross-species epitopes in malaria vaccine design.
Mitran, C.J., and Yanow, S.K.
Frontiers in Immunology. 2020 January; 11 (335)
Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA.
Gnidehou S, Mitran CJ, Arango E, Banman S, Mena A, Medawar E, Lima BAS, Doritchamou J, Rajwani J, Jin A, Gavina K, Ntumngia F, Duffy P, Narum D, Ndam NT, Nielsen MA, Salanti A, Kano FS, Carvalho LH, Adams JH, Maestre A, Good MF, Yanow SK.
The Journal of Infectious Diseases. 2019 January; 219 (1):110-120