Emmanuelle Cordat
Contact
Professor, Faculty of Medicine & Dentistry - Physiology Dept
- cordat@ualberta.ca
- Phone
- (780) 492-0209
- Address
-
7-34 Medical Sciences Building
8613 - 114 St NWEdmonton ABT6G 2H7
Overview
Area of Study / Keywords
renal physiology membrane transporters bicarbonate transporters claudins polarized epithelium collecting duct tight junctions calcium homeostasis acid-base homeostasis paracellular and transcelllar transport
About
Dr. Cordat joined the Department of Physiology at the University of Alberta in 2007 after completing a postdoctoral fellowship at the University of Toronto and a Ph.D. degree at the University of Nice/Sophia-Antipolis (France). She is a member of the American Society of Nephrology, the American Society of Cell Biology and the Canadian Society for Molecular Biosciences. She regularly reviews manuscripts, seats on several editorial panels and reviews grant applications for the Kidney Foundation of Canada, the Canadian Institutes of Health Research and other funding agencies.
The Cordat’s lab is looking for a highly motivated, hard-working and well-organized graduate student to join the team!
Website: https://sites.google.com/ualberta.ca/cordat/
Research
Research in the Cordat’s lab is focused on renal handling of ions, with a particular emphasis on the physiological role of bicarbonate transporters in the renal collecting duct. These transporters are expressed in many organs where they participate in acid-base homeostasis and electrolyte balance. Any imbalance of plasma bicarbonate homeostasis alters a number of physiological processes, including homeostasis of oxalate, a component of 80 % of kidney stones, indirect regulation of water reabsorption, plasma pH homeostasis, bile duct function, spermatogenesis, vision, hearing or cardiovascular function.
The Cordat’s lab works on the physiology and pathophysiology of renal intercalated cells and the specific role of the kidney anion exchanger 1 (kAE1) protein in these cells. Inherited kAE1 mutations can induce a kidney disease called distal renal tubular acidosis (dRTA). This disease causes failure to thrive, muscle weakness and kidney stones.
Our laboratory has 3 main research topics: the first focuses on the pathophysiology of the renal intercalated cell loss in dRTA patients, the second investigates the persistence of kidney stone development in dRTA patients even after their acidosis is corrected and the third one aims at understanding the role of intercalated cells in innate immunity.
Our research will have an impact on our understanding of (1) kidney stone formation, a painful condition that affects one in ten Canadians throughout their lifetime, and (2) urinary tract infections, a common condition that causes roughly 500,000 visits per year to physicians in Canada.
Techniques used in Dr. Cordat's lab: a variety of cell biology and biochemical techniques including immunoblotting, immunoprecipitations, immunofluorescence coupled with confocal microscopy, primary and immortalized cell culture and electrophysiological approaches.
Teaching
Co-coordinator of PHYSL 461, 466, 467, 468/469 courses
Lecturer for PHYSL 407
Teacher for PHYSL 310
Featured Publications
Intercalated cells and innate immunity response
65th Canadian Society for Molecular Biosciences . 2022 April;
The Effect of Naturally Occurring Red Blood Cell Anion Exchanger 1/SLC4A1 Variants on Selenium (± Arsenic) Accumulation
65th Canadian Society for Molecular Biosciences . 2022 April;
The link between kAE1 mutant expression and alpha intercalated cell loss in distal renal tubular acidosis
65th Canadian Society for Molecular Biosciences . 2022 April;
Beggs M.R., Young K., Pan W., O'Neill D.D., Saurette M., Plain A., Rievaj J., Doschak M.R., Cordat E., Dimke H., Alexander R.T.
Proceedings of the National Academy of Sciences. 2021 November; 118 (48) 10.1073/pnas.2111247118
Li X., Cordat E., Schmitt M.J., Becker B.
Yeast. 2021 September; 38 (9):521-534 10.1002/yea.3652