Dawei Zhang

Professor, Faculty of Medicine & Dentistry - Pediatrics Dept

Contact Overview Publications

Contact

Professor, Faculty of Medicine & Dentistry - Pediatrics Dept

Email: dzhang@ualberta.ca
Address: 303 Heritage Medical Research Centre
11207 - 87 Ave NW

Edmonton AB

T6G 2S2

Overview

About

Dr. Dawei Zhang is currently appointed as Professor in the Department of Pediatrics in the Faculty of Medicine & Dentistry.

Research

We study metabolism and human diseases that are linked to it, such as atherosclerotic cardiovascular disease, non-alcohol fatty liver disease, and arthritis. The ultimate goal is to identify novel proteins and pathways relevant to these diseases and then translate this knowledge to develop novel therapeutics with improved efficacy.

1) PCSK9-promoted LDLR degradation. 2)The role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metabolism and human disease. 3)Surf4 and lipid metabolism.

Website: https://sites.google.com/ualberta.ca/zhang-lab/

Teaching

Physiology 455/555: Physiology of Lipids and Lipoproteins

Featured Publications

Inducible global knockout of surfeit locus protein 4 in adult mice results in hypolipidemia, intestinal lipid accumulation, liver injury, and increased mortality.

Chen W, Chen Y, Song B, Zhai L, Tao G, Wang B, Liu B, Wang H, Zhang CX, Gu HM, Yin D, Qin S, Zhang DW.

Biochim Biophys Acta Mol Cell Biol Lipids.. 2024 November; 14 10.1016/j.bbalip.2024.159577

Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis.

Chen L, Chen D, Pan Y, Mo Y, Lai B, Chen H, Zhang DW, Xia XD.

Cell Death Dis. . 2024 November; 15 (11):786 10.1038/s41419-024-07127-1

The spectrum of novel ABCB11 gene variations in children with progressive familial intrahepatic cholestasis type 2 in Pakistani cohorts

Riaz H, Zheng B, Zheng Y, Liu Z, Gu HM, Imran M, Yaqoob T, Bhinder MA, Zhang DW, Zahoor MY.

Sci Rep.. 2024 August; 14 (1):18876 10.1038/s41598-024-59945-0

Hepatic Surf4 Deficiency Impairs Serum Amyloid A1 Secretion and Attenuates Liver Fibrosis in Mice

Wang B, Li H, Gill G, Zhang X, Tao G, Liu B, Zhai L, Chen W, Wang H, Gu HM, Qin S, Zhang DW.

Research (Wash D C). 2024 August; 7 (0435) 10.34133/research.0435

Cholesin, a new hormone bridges intestinal cholesterol absorption and hepatic synthesis

Peter U Amadi, Da-Wei Zhang

Life Metabolism. 2024 June; 3 (4):loae024 10.1093/lifemeta/loae024

Extracellular matrix turnover: phytochemicals target and modulate the dual role of matrix metalloproteinases (MMPs) in liver fibrosis

Usman Sabir, Hong‐mei Gu, Da‐Wei Zhang

Phytotherapy Research. 2023 November; 10.1002/ptr.7959

Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis.

Xia XD, Govind Gill, Lin H, Daniela M. Roth, Gu HM, Wang XJ, Su FY, Adekunle Alabi, Alexiou M, Zhang Z, Wang GQ, Graf D, Zhang DW

Matrix biology : journal of the International Society for Matrix Biology. 2023 August; 10.1016/j.matbio.2023.08.003

The mitophagy pathway and its implications in human diseases

Shouliang Wang, Haijiao Long, Lianjie Hou, Baorong Feng, Zihong Ma, Ying Wu, Yu Zeng, Jiahao Cai, Da-wei Zhang, Guojun Zhao

Signal Transduction and Targeted Therapy. 2023 August; 10.1038/s41392-023-01503-7

Surf4 (Surfeit Locus Protein 4) Deficiency Reduces Intestinal Lipid Absorption and Secretion and Decreases Metabolism in Mice

Geru Tao, Hao Wang, Yishi Shen, lei zhai, Boyan Liu, Bingxiang Wang, Wei Chen, Sijie Xing, Yuan Chen, Hong-Mei Gu, Shucun Qin, Da-wei Zhang

Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 April; 10.1161/atvbaha.123.318980

Surf4, cargo trafficking, lipid metabolism, and therapeutic implications

Yishi Shen, Hong-Mei Gu, Shucun Qin, Da-Wei Zhang

Journal of Molecular Cell Biology. 2023 February; 10.1093/jmcb/mjac063

Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor

Frontiers in Cardiovascular Medicine. 2022 August; 10.3389/fcvm.2022.917238

Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis.

Nature communications. 2021 March; 10.1038/s41467-021-22167-3

Proprotein Convertase Subtilisin/Kexin-Type 9 and Lipid Metabolism.

Advances in experimental medicine and biology. 2020 January; 10.1007/978-981-15-6082-8_9

Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2020 January; 10.1016/j.bbalip.2019.158555

The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2020 January; 10.1016/j.bbalip.2020.158660

Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding

Journal of Lipid Research. 2019 January; 10.1194/jlr.M089193

Identification of an Amino Acid Residue Critical for Plasma Membrane Localization of ATP-Binding Cassette Transporter G1-Brief Report

Arteriosclerosis, Thrombosis, and Vascular Biology. 2016 January; 10.1161/ATVBAHA.115.306592

Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2014 January; 10.1016/j.bbalip.2014.02.002

Characterization of the role of a highly conserved sequence in ATP binding cassette transporter G (ABCG) family in ABCG1 Stability, oligomerization, and trafficking

Biochemistry. 2013 January; 10.1021/bi401285j

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

Journal of Biological Chemistry. 2007 January; 10.1074/jbc.M702027200

Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8

Journal of Biological Chemistry. 2006 January; 10.1074/jbc.M512277200

Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): Effect on substrate specificity

Drug Metabolism and Disposition. 2006 January; 10.1124/dmd.105.007740

Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): Identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1

Biochemistry. 2004 January; 10.1021/bi0495230

Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3.

Biochemistry. 2003 August; 10.1021/bi034462b

Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): Identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state

Journal of Biological Chemistry. 2003 January; 10.1074/jbc.M308403200

Determinants of the substrate specificity of multidrug resistance protein 1: Role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17

Journal of Biological Chemistry. 2002 January; 10.1074/jbc.M201311200

Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [ <sup>125</sup>I]LY475776 and azidophenacyl-[ <sup>35</sup>S]glutathione

Journal of Biological Chemistry. 2002 January; 10.1074/jbc.M206058200

Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: Evidence for functional interaction between transmembrane helices 14 and 17

Journal of Biological Chemistry. 2001 January; 10.1074/jbc.M105063200

Identification of an Amino Acid Residue in Multidrug Resistance Protein 1 Critical for Conferring Resistance to Anthracyclines

Journal of Biological Chemistry. 2001 January; 10.1074/jbc.M010008200

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