Fred Colbourne, PhD

Professor, Faculty of Science - Psychology Science

Contact

Professor, Faculty of Science - Psychology Science
Email
frederick.colbourne@ualberta.ca
Phone
(780) 492-5268
Address
P-459 Bio Science - Psychology Wing
11355 - Saskatchewan Drive
Edmonton AB
T6G 2E9

Overview

Area of Study / Keywords

Stroke Neuroprotection Rehabilitation Animal Models Therapeutic Hypothermia Edema Intracranial Pressure Neuroplasticity


About

I have been a faculty member at U of A since 2000. Prior to this I completed post-doctoral training at the University of Lethbridge and the University of Calgary. I completed my PhD (Basic Medical Sciences in the Faculty of Medicine, 1995) and undergraduate degrees (Hons. Psychology, 1991) at Memorial University of Newfoundland.


For fun outside the lab, I enjoy nature (hiking, camping, and photography: http://www.flickr.com/photos/fred_colbourne/).



Research

My students and I study the ischemic and hemorrhagic brain injuries that result from stroke and related conditions. We use animal models and a wide array of research techniques and tools to better understand the pathophysiology of cell damage (e.g., the role of brain edema) and dysfunction (e.g., alterations in cell volume). Furthermore, our primary goal is to comprehensively test potential therapies in our translationally-oriented studies. This includes seeking ways to reduce cell death through the use of neuroprotective therapies (e.g., hypothermia and various drugs), and attempting to augment brain plasticity to further improve behavioral recovery (e.g., rehabilitation therapies). Our publications are listed below, with some available through the links provided, or they can be obtained by emailing Dr. Colbourne.


Current set of awesome graduate students:

  • A. Kalisvaart (PhD, Psychology; funded by CIHR-M and a U of A graduate scholarship)
  • B. Fedor (PhD, NMHI; funded by a Faculty of Medicine and Dentistry Lawson Studentship)
  • C. Wilkinson (PhD, Psychology; funded by: CIHR-CGS, U of A President's Doctoral Prize of Distinction, Izaak Walton Killam Memorial Scholarship, Dorothy J. Killam Memorial Prize and others)
  • L. Liddle (PhD, Psychology; funded by CIHR-M, Alberta Graduate Excellence Scholarship, and others)
  • T. Kung (MSc, Psychology; funded by Alberta Graduate Excellence Scholarship).

+ volunteers, psyco496 and honor's students from psychology and the NMHI.


Interested in joining the lab? Please e-mail Fred and provide a brief statement on what you are interested in (e.g., psyco496, honor's, summer studentships, grad school), what you hope to learn and how this may benefit you (e.g., career ambitions), and a brief summary of your experiences and grades (e.g., overall GPA, and past research experience). Please note that I aim to only supervise students who have a strong GPA (e.g., 3.5 or better), are dedicated and hard working, and have a genuine interest in research. Learning and advancement opportunities include:

  • Basic science and clinical knowledge of stroke, cardiac arrest and related disciplines (e.g., brain trauma).
  • A wide range of interdisciplinary research methods, as noted below (e.g., from analyzing elements to assessing behaviour).
  • How to conduct research with a high level of scientific and translational rigour.
  • Oral presentation skills (lab meetings and conferences).
  • Writing skills (reports, applications and papers). Most importantly, many of the undergraduates in my lab have earned authorship on papers.
  • Organizational and networking skills (e.g., working in a team setting).
  • Collaborators and friends.
  • Funding. Many students in my lab obtain competitive awards.
  • All of this means that my students have strong applications to graduate school (psychology and neuroscience), postdoctoral positions, or professional programs (MD, OT, etc.).


Lab methods we use (Standard Operating Procedures (SOPs) can be obtained by emailing your request to Dr. Colbourne):

  • Behavioral assays (motor, sensory and cognitive tests),
  • Biochemical assays (hemoglobin, iron, etc.),
  • Blood brain barrier assays (Evan's blue and Gd extravasation),
  • Cerebral edema (brain swelling assay),
  • Drug administration (IP, SC, IV, ICV, and osmotic mini-pump delivery),
  • Light microscopy (frozen, vibratome, and paraffin embedding; CV, H&E, and other stains)
  • Electron microscopy
  • Inductively coupled plasma mass spectroscopy (for Na, K, Fe, Gd, etc.)
  • Rehabilitation protocols (environmental enrichment and skill reaching training),
  • Statistical procedures (ANOVA, regression, and meta-analysis),
  • Stroke models (intracerebral hemorrhage, ischemic stroke, and global ischemia),
  • Telemetry recordings (body and brain temperature, blood pressure and heart rate, intracranial pressure, and EEG),
  • Therapeutic hypothermia (local and systemic protocols),
  • Transcriptomics (microarrays),
  • Unbiased stereology (cell density and volume assessment) and lesion volume determination,
  • X-ray fluorescence imaging (for K, Cl, Fe, etc.) and related methods (e.g., Fourier-transform infrared imaging).


Lab Research Funding:

Current Operating Grants: CIHR.

Past Operating Grants: CIHR, HSFC, NSERC, NCE.

Past Salary Support (FC): Alberta Heritage Foundation for Medical Research, Alberta Innovates - Health Solutions, and Canada Research Chairs (Tier 1).

Announcements

Recent Publications from My Lab by Graduate and Undergraduate Students (Past 6 Months):

  • December 2020: Kalisvaart, A.C.J., Wilkinson, C.M., Gu, S., Kung, T., Yager, J., Winship, I., van Landeghem, F. and Colbourne, F. An update to the Monro-Kellie Doctrine to reflect tissue compliance after severe ischemic and hemorrhagic stroke, Scientific Reports, in press.
  • October 2020: Wilkinson, C. M., Kung, T., Jickling, G. and Colbourne, F. Intracranial pressure after intracerebral hemorrhage: A translational perspective. Brain Hemorrhages, in press.

Recent Student Awards (Past 6 Months):

  • November 2020: Lane Liddle (PhD student) and Tiffany Kung (MSc student) won Alberta Graduate Excellence Scholarships (AGES).
  • October 2020: Cassandra Wilkinson (PhD student) won the prestigious Dorothy J. Killam Memorial Prize and the Izaak Walton Killam Memorial Scholarships (https://blog.ualberta.ca/meet-the-2020-killam-laureates-92e1c9ac8a44).
  • September 2020: Cassandra Wilkinson (PhD student) won the Valerie Jagoldas Graduate Scholarship (Faculty of Science).  

Courses

PSYCO 403 - Recent Advances in Experimental Psychology: Models and Theories

Discussion of advanced concepts and theories developed by selected fields within experimental psychology. The course will examine the relation between theory and data in these fields. Prerequisites: STAT 141 or 151 or SCI 151 and a 300-level PSYCO course. Students must check with the Department for the topics for the year and any additional prerequisites. [Faculty of Science]

Winter Term 2021
PSYCO 505 - Conference Course in Psychology

[Faculty of Science]

Winter Term 2021

Browse more courses taught by Fred Colbourne

Publications

An update to the Monro-Kellie Doctrine to reflect tissue compliance after severe ischemic and hemorrhagic stroke
Author(s): Kalisvaart, A.C.J., Wilkinson, C.M., Gu, S., Kung, T., Yager, J., Winship, I., van Landeghem, F. and Colbourne, F.
Publication Date: 12/1/2020
Publication: Scientific Reports
Page Numbers: in press

Intra-arterial cooling for stroke: a systematic review and meta-analysis.
Author(s): Liddle, L.J., Dirks, C., Fedor, B., Almekhlafi, M. and Colbourne, F.
Publication Date: 11/12/2020
Publication: Frontiers in Neurology
Page Numbers: accepted

Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.
Author(s): Kung, T.F.C., Wilkinson, C.M., Dirks, C.A., Jickling, G.J., and Colbourne, F.
Publication Date: 10/27/2020
Page Numbers: under review

Intracranial pressure after intracerebral hemorrhage: A translational perspective.
Author(s): Wilkinson, C. M., Kung, T., Jickling, G. and Colbourne, F.
Publication Date: 10/20/2020
Publication: Brain Hemorrhages
Page Numbers: in press
External Link: https://doi.org/10.1016/j.hest.2020.10.002
Infusion of cold saline into the carotid artery does not affect outcome after intrastriatal hemorrhage
Author(s): Liddle, L. J., Prokop, B., Dirks, C., Demchuk, A., Almekhlafi, M.A., and Colbourne, F.
Publication Date: 9/3/2020
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 10
Page Numbers: 171-178
External Link: https://www.liebertpub.com/doi/full/10.1089/ther.2020.0010
Translational intracerebral hemorrhage research: has current neuroprotection research ARRIVEd at a standard for experimental design and reporting?
Author(s): Liddle, L. J., Ralhan, S., Ward, D. L. and Colbourne, F.
Publication Date: 6/5/2020
Publication: Translational Stroke Research
Volume: 11
Page Numbers: 1203-1213
External Link: https://doi.org/10.1007/s12975-020-00824-x
Therapeutic hypothermia in acute ischemic stroke – A systematic review and meta-analysis.
Author(s): Kuczynski, A.M., Marzoughi, S., Sultan, A.S., Colbourne, F., Menon, B., Goyal, M., Demchuk, A.M. and Almekhlafi, M.A.
Publication Date: 5/5/2020
Publication: Current Neurology and Neuroscience Reports
Volume: 20
External Link: https://link.springer.com/article/10.1007/s11910-020-01029-3
The Collagenase Model of Intracerebral Hemorrhage in Awake, Freely Moving Animals: The Effects of Isoflurane.
Author(s): Wilkinson, C.M., Kalisvaart, A.C.J. Kung, T.F.C., Maisey, D.R., Klahr, A.C., Dickson, C.T., Colbourne, F.
Publication Date: 2/1/2020
Publication: Brain Research
Volume: 1728
External Link: https://www.sciencedirect.com/science/article/pii/S000689931930647X
A review of ex vivo elemental mapping methods to directly image homeostasis of diffusible ions (Na+, K+, Mg2+, Ca2+, Cl-) within brain tissue.
Author(s): Hartnell, D., Andrews, W., Smith, N., McCullum, E., Rajan, R., Colbourne, F., Takechi, R., Lam, V., Pushie, M. J., Kelly, M. and Hackett, M.J.
Publication Date: 1/22/2020
Publication: Frontiers in Neuroscience
Volume: 13
External Link: https://www.frontiersin.org/articles/10.3389/fnins.2019.01415/full
Hypothermia: impact on plasticity following brain injury
Author(s): Kalisvaart, A., Prokop, B. and Colbourne, F.
Publication Date: 12/27/2019
Publication: Brain Circulation
Volume: 5
Page Numbers: 169-178

Poly-arginine-18 peptides do not exacerbate bleeding or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
Author(s): Liddle, L., Reinders, R., South, S., Blacker, D., Knuckey, N., Colbourne, F. and Meloni, B.
Publication Date: 11/7/2019
Publication: PLOS One
Volume: 14
External Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224870
Sex differences in central nervous system plasticity and pain in experimental autoimmune encephalomyelitis
Author(s): Catuneanu, A., Paylor, J.W., Winship, I., Colbourne, F., and Kerr, B.
Publication Date: 5/1/2019
Publication: Pain
Volume: 160
Page Numbers: 1037-1049
External Link: https://journals.lww.com/pain/Abstract/2019/05000/Sex_differences_in_central_nervous_system.7.aspx
Glibenclamide, a Sur1-Trpm4 antagonist, does not improve outcome after collagenase induced intracerebral hemorrhage
Author(s): Wilkinson, C., Brar, P.S., Balay, C.J. and Colbourne, F.
Publication Date: 5/1/2019
Publication: PLOS One
Volume: 14
External Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215952
Failure of bumetanide to improve outcome after intracerebral hemorrhage in rat.
Author(s): Wilkinson, C., Fedor, B., Aziz, J., Nadeau, C., Brar, P., Clark, J.J. and Colbourne, F.
Publication Date: 1/10/2019
Publication: PLOS One
Volume: 14
Issue: 5
External Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210660
N-acetylcysteine blocks ALOX5-induced ferroptosis and synergizes with PGE2 to treat brain hemorrhage
Author(s): Karuppagounder, S. S., Alin, L., Chen, Y., Brand, D. Bourassa, M. W., Dietrich, K., Wilkinson, C., Nadeau, C. A., Perry, S., Pinto, J., Darley-Usmar, V., Sanchez, S., Milne, G. L., Pratico, D., Holman, T. R., Colbourne, F. and Ratan, R. R.
Publication Date: 10/7/2018
Publication: Annals of Neurology
Volume: 84
Page Numbers: 854-872
External Link: https://dx.doi.org/10.1002%2Fana.25356
Acetazolamide mitigates intracranial pressure spikes without affecting functional outcome after experimental hemorrhagic stroke
Author(s): Williamson, M. R., Wilkinson, C. M., Dietrich, K. and Colbourne, F.
Publication Date: 9/17/2018
Publication: Translational Stroke Research
Volume: 10
Page Numbers: 428-439
External Link: https://link.springer.com/article/10.1007/s12975-018-0663-6
Hyperoxia enhances slow-wave forebrain states in urethane anesthetized and naturally sleeping rats
Author(s): Hauer, B. Negash, B., Chan, K., Vuong, W., Colbourne, F., Pagliardini, S, and Dickson, C.
Publication Date: 9/12/2018
Publication: Journal of Neurophysiology
Volume: 120
Page Numbers: 1505-1515
External Link: https://journals.physiology.org/doi/full/10.1152/jn.00373.2018
Prolonged Blood-Brain Barrier Injury Occurs After Experimental Intracerebral Hemorrhage and Is Not Acutely Associated with Additional Bleeding
Author(s): Nadeau, C., Dietrich, K., Wilkinson, C., Crawford, A., George, G., Nichol, H. and Colbourne, F.
Publication Date: 6/14/2018
Publication: Translational Stroke Research
Volume: 10
Page Numbers: 287-297
External Link: https://doi.org/10.1007/s12975-018-0636-9
Mild contralesional hypothermia reduces use of the unimpaired limb in a skilled reaching task after motor cortex injury in rat.
Author(s): Klahr, A.C., Fagan, K., Aziz, J.R., John, R. and Colbourne, F.
Publication Date: 6/1/2018
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 8
Page Numbers: 90-98
External Link: https://www.liebertpub.com/doi/10.1089/ther.2017.0037
Measurement of Intracranial Pressure in Freely Moving Rats
Author(s): Williamson, M., John, R. and Colbourne, F.
Publication Date: 2018
Publication: Methods Mol Biol
Volume: 1717
Page Numbers: 17-25
External Link: https://doi.org/10.1007/978-1-4939-7526-6_2
Temperature control in rodent neuroprotection studies: methods and challenges.
Author(s): Klahr, A., Nadeau, C. and Colbourne, F.
Publication Date: 3/1/2017
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 7
Page Numbers: 42-49
External Link: https://www.liebertpub.com/doi/abs/10.1089/ther.2016.0018
Evidence for decreased brain parenchymal volume after large intracerebral hemorrhages: a potential mechanism limiting intracranial pressure rises.
Author(s): Williamson, M.R. and Colbourne, F.
Publication Date: 2017
Publication: Translational Stroke Research
Volume: 8
Page Numbers: 386-396
External Link: https://doi.org/10.1007/s12975-017-0530-x
Rehabilitation augments hematoma clearance and attenuates oxidative injury and ion dyshomeostasis after brain hemorrhage.
Author(s): Williamson, M.J., Dietrich, K., Hackett, M.J., Caine, S., Nadeau, C., Aziz, J., Nichol, H., Paterson, P.G., and Colbourne, F.
Publication Date: 11/29/2016
Publication: Stroke
Volume: 48
Page Numbers: 195-203
External Link: https://www.ahajournals.org/doi/full/10.1161/strokeaha.116.015404
Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis
Author(s): Potter, L., Paylor, J., Suh, J., Tenorio, G., Caliaperumal, I., Colbourne, F., Baker, G., Winship, I. and Kerr, B.
Publication Date: 6/10/2016
Publication: Journal of Neuroinflammation
Volume: 13
External Link: https://doi.org/10.1186/s12974-016-0609-4
Therapeutic targeting of oxygen-sensing prolyl-hydroxylase domain enzymes abrogates atf4-dependent death and improves outcomes from brain hemorrhage.
Author(s): Karuppagounder, S.S., Alim, I., Khim S.J., Bourassa, M.W., Sleiman, S.F., John, R.F., Thinnes, C.C., Yeh, T.-L., Demetriades, M., Neitemeier, S., Cruz, D., Gazaryan, I., Killilea, D., Morgenstern, L., Xi, G.H., Keep, R.F., Schallert, T., Tappero, R.V., Zhong, J., Cho, S., Maxfield, F.R., Holman, T.R., Culmsee, C., Fong, G.H., Cave, J., Schofield, C.J., Colbourne, F., Coppola, G., Ratan, R.R
Publication Date: 3/2/2016
Publication: Science Translation Medicine
Volume: 8
External Link: https://doi.org/10.1126/scitranslmed.aac6008
Prolonged Localized Mild Hypothermia Does Not Affect Seizure Activity After Intracerebral Hemorrhage in Rats
Author(s): Klahr, A., Dietrich, K., Dickson, C. and Colbourne, F.
Publication Date: 3/1/2016
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 6
Page Numbers: 40-47
External Link: https://doi.org/10.1089/ther.2015.0028
Delayed localized hypothermia reduces intracranial pressure following collagenase-inducedintracerebral hemorrhage in rat
Author(s): John, R. and Colbourne, F.
Publication Date: 2016
Publication: Brain Research
Volume: 1633
Page Numbers: 27-36
External Link: https://doi.org/10.1016/j.brainres.2015.12.033
Therapeutic hypothermia fails to mitigate iron-induced injury in rat
Author(s): Wowk, S., Ma, Y. and Colbourne, F.
Publication Date: 2016
Publication: Therapeutic Hypothermia and Temperature Management.
Volume: 6
Page Numbers: 23-29
External Link: https://doi.org/10.1089/ther.2015.0020
Examining potential side effects of therapeutic hypothermia in experimental intracerebral hemorrhage.
Author(s): Wowk, S., Fagan, K., Ma, Y., Nichol, H. and Colbourne, F.
Publication Date: 2016
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 37
Page Numbers: 2975-2986
External Link: https://doi.org/10.1177%2F0271678X16681312
A New Method To Image Heme-Fe, Total Fe, and Aggregated Protein Levels after Intracerebral Hemorrhage
Author(s): Hackett, M., DeSouza, M., Caine, S., Bewer, B.,Nichol, H., Paterson, P. and Colbourne, F.
Publication Date: 2/19/2015
Publication: ACS Chemical Neuroscience
Volume: 6
Page Numbers: 761-770
External Link: https://doi.org/10.1021/acschemneuro.5b00037
Seizure activity occurs in the collagenase but not the blood infusion model of striatal hemorrhagic stroke in rats.
Author(s): Klahr, A., Dickson, C. and Colbourne, F.
Publication Date: 2015
Publication: Translational Stroke Research
Volume: 6
Page Numbers: 29-38
External Link: https://doi.org/10.1007/s12975-014-0361-y
Mild hypothermia does not reduce thrombin-induced brain injury.
Author(s): Wowk, S., Ma, Y. and Colbourne F.
Publication Date: 12/1/2014
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 4
Page Numbers: 180-187
External Link: https://doi.org/10.1089/ther.2014.0014
Thrombin causes neuronal atrophy and acute but not chronic cell death.
Author(s): Caliaperumal, J., Brodie, S., Ma, Y. and Colbourne, F.
Publication Date: 11/1/2014
Publication: Canadian Journal of Neurological Sciences
Volume: 41
Issue: 6
Page Numbers: 714-720
External Link: https://doi.org/10.1017/cjn.2014.105
Intracranial pressure measured in freely moving rats for days after intracerebral hemorrhage
Author(s): Hiploylee, C. and Colbourne, F.
Publication Date: 5/1/2014
Publication: Experimental Neurology
Volume: 255
Page Numbers: 49-55
External Link: https://doi.org/10.1016/j.expneurol.2014.02.017
Localized hypothermia aggravates bleeding in the collagenase model of intracerebral hemorrhage.
Author(s): John, R., Williamson, M., Dietrich, K. and Colbourne, F.
Publication Date: 2014
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 5
Page Numbers: 19-25
External Link: https://doi.org/10.1089/ther.2014.0020
Rehabilitation improves behavioral recovery and lessens cell death without affecting iron, ferritin, transferrin or inflammation after intracerebral hemorrhage in rats
Author(s): Caliaperumal, J. and Colbourne, F.
Publication Date: 12/27/2013
Publication: Neurorehabilitation and Neural Repair
Volume: 28
Page Numbers: 395-404
External Link: https://doi.org/10.1177%2F1545968313517758
Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome
Author(s): Auriat, A., Silasi, G., Wei, Z., Paquette, R., Paterson, P., Nichol, H. and Colbourne, F.
Publication Date: 12/3/2013
Publication: Experimental Neurology
Volume: 234
Page Numbers: 136-143
External Link: https://dx.doi.org/10.1016%2Fj.expneurol.2011.12.030
Bipyridine, an iron chelator, does not lessen intracerebral iron-induced damage or improve outcome after intracerebral hemorrhagic stroke in rats.
Author(s): Caliaperumal, J., Wowk, S., Jones, S., Ma, Y. and Colbourne, F.
Publication Date: 12/1/2013
Publication: Translational Stroke Research
Volume: 4
Page Numbers: 719-728
External Link: https://doi.org/10.1007/s12975-013-0272-3
Postischemic diazepam does not reduce hippocampal CA1 injury and does not improve hypothermic neuroprotection
Author(s): Davies, L., MacLellan, C., Corbett, D. and Colbourne, F.
Publication Date: 7/9/2013
Publication: Brain Research
Volume: 1013
Page Numbers: 223-229
External Link: https://doi.org/10.1016/j.brainres.2004.04.015
Intraparenchymal ferrous iron infusion causes neuronal atrophy, cell death and progressive tissue loss: implications for intracerebral hemorrhage
Author(s): Caliaperumal, J., Ma, Y. and Colbourne, F.
Publication Date: 10/1/2012
Publication: Experimental Neurology
Volume: 15
Page Numbers: 363-369
External Link: https://doi.org/10.1016/j.expneurol.2012.07.001
Prolonged therapeutic hypothermia does not adversely impact neuroplasticity after global ischemia in rats
Author(s): Silasi, G., Klahr, A., Hackett, M., Auriat, A., Nichol, H. and Colbourne, F.
Publication Date: 8/1/2012
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 32
Page Numbers: 1525-1534
External Link: https://dx.doi.org/10.1038%2Fjcbfm.2012.38
Prolonged Hypothermia in Rat: A Safety Study Using Brain-Selective and Systemic Treatments
Author(s): Auriat, A., Klahr, A., Silasi, G., MacLellan, C., Penner, M., Clark, D. and Colbourne, F.
Publication Date: 4/25/2012
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 2
Page Numbers: 37-43
External Link: https://doi.org/10.1089/ther.2012.0005
A critical appraisal of experimental intracerebral hemorrhage research
Author(s): MacLellan, C., Paquette, R. and Colbourne, F.
Publication Date: 4/1/2012
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 32
Page Numbers: 612-627
External Link: https://doi.org/10.1038/jcbfm.2012.8
Unilateral brain hypothermia as a method to examine efficacy and mechanisms of neuroprotection against global ischemia.
Author(s): Silasi, G. and Colbourne, F.
Publication Date: 7/8/2011
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 1
Page Numbers: 87-94
External Link: https://doi.org/10.1089/ther.2011.0005
Rehabilitation promotes recovery after whole-blood induced intracerebral hemorrhage in rats
Author(s): MacLellan, C. L., Plummer, N., Silasi, G., Auriat, A.M. and Colbourne, F.
Publication Date: 6/1/2011
Publication: Neurorehabilitation and Neural Repair
Volume: 25
Page Numbers: 477-83
External Link: https://doi.org/10.1177/1545968310395602
Therapeutic hypothermia influences cell genesis and survival in the rat hippocampus following global ischemia.
Author(s): Silasi, G. and Colbourne, F.
Publication Date: 3/2/2011
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 31
Page Numbers: 1725-1735
External Link: https://doi.org/10.1038%2Fjcbfm.2011.25
Brief hyperthermia does not worsen outcome after striatal hemorrhage in rats
Author(s): Penner, M., Silasi, G., Wowk, S, Warkentin, L., Colbourne, F.
Publication Date: 2/1/2011
Publication: Current Neurovascular Research
Volume: 8
Page Numbers: 35-43
External Link: https://doi.org/10.2174/156720211794520198
Protein energy malnutrition alters thermoregulatory homeostasis and the response to brain ischemia
Author(s): Smith, S.E., Prosser-Loose, E.J., Colbourne, F. and Paterson, P.G.
Publication Date: 2/1/2011
Publication: Current Neurovascular Research
Volume: 8
Page Numbers: 64-74
External Link: https://doi.org/10.2174/156720211794520206
Rehabilitation after intracerebral hemorrhage in rats improves recovery with enhanced dendritic complexity but no effect on cell proliferation.
Author(s): Auriat, A., Wowk, S. and Colbourne, F.
Publication Date: 12/6/2010
Publication: Behavioral Brain Research
Volume: 214
Page Numbers: 42-47
External Link: https://doi.org/10.1016/j.bbr.2010.04.025
Rodent models of intracerebral hemorrhage.
Author(s): MacLellan, C., Silasi, G., Auriat, A. and Colbourne, F.
Publication Date: 10/1/2010
Publication: Stroke
Volume: 41[suppl 1]
Page Numbers: S95-S98
External Link: https://doi.org/10.1161/strokeaha.110.594457
Secondary damage in the spinal cord following motor cortex injury in rats.
Author(s): Weishaupt, N., Silasi, G., Colbourne, F. and Fouad, K.
Publication Date: 8/1/2010
Publication: Journal of Neurotrauma
Volume: 27
Page Numbers: 1387-1397
External Link: https://doi.org/10.1089/neu.2010.1346
Failure of deferoxamine, an iron chelator, to improve outcome after collagenase-induced intracerebral hemorrhage in rats.
Author(s): Warkentin, L., Auriat, A., Wowk, S. and Colbourne, F.
Publication Date: 1/14/2010
Publication: Brain Research
Volume: 1309
Page Numbers: 95-103
External Link: https://doi.org/10.1016/j.brainres.2009.10.058
Treatments (12 and 48 h) with systemic and brain-selective hypothermia techniques after permanent focal cerebral ischemia in rat.
Author(s): Clark, D., Penner, M., Wowk, S., Orellana-Jordan, I. and Colbourne, F.
Publication Date: 12/1/2009
Publication: Experimental Neurology
Volume: 220
Page Numbers: 391-399
External Link: https://doi.org/10.1016/j.expneurol.2009.10.002
Transient global cerebral ischemia produces morphologically necrotic, not apoptotic neurons.
Author(s): Colbourne, F. and Auer, R.
Publication Date: 9/15/2009
Publication: Acute Neuronal Injury
Page Numbers: 121-130
External Link: https://link.springer.com/chapter/10.1007/978-0-387-73226-8_8
Treatment of intracerebral hemorrhage in rats with 12 h, 3 days and 6 days of selective brain hypothermia.
Author(s): Fingas, M., Penner, M., Silasi, G. and Colbourne, F.
Publication Date: 9/1/2009
Publication: Experimental Neurology
Volume: 219
Page Numbers: 156-162
External Link: https://doi.org/10.1016/j.expneurol.2009.05.007
Long-term assessment of motor and cognitive behaviors in the intraluminal perforation model of subarachnoid hemorrhage in rats.
Author(s): Silasi, G. and Colbourne, F.
Publication Date: 3/17/2009
Publication: Behavioral Brain Research
Volume: 198
Page Numbers: 380-387
External Link: https://doi.org/10.1016/j.bbr.2008.11.019
Use of prolonged hypothermia to treat ischemic and hemorrhagic stroke.
Author(s): MacLellan, C. L., Clark, D. L., Silasi, G and Colbourne, F.
Publication Date: 3/1/2009
Publication: Journal of Neurotrauma
Volume: 26
Page Numbers: 313-323
External Link: https://doi.org/10.1089/neu.2008.0580
A high fat diet does not exacerbate CA1 injury and cognitive deficits following global ischemia in rats.
Author(s): Arvanitidis, A., Corbett, D. and Colbourne, F.
Publication Date: 2/3/2009
Publication: Brain Research
Volume: 1252
Page Numbers: 192-200
External Link: https://doi.org/10.1016/j.brainres.2008.11.058
Use of telemetry blood pressure transmitters to measure intracranial pressure (ICP) in freely moving rats.
Author(s): Silasi, G., MacLellan, C. and Colbourne, F.
Publication Date: 2/1/2009
Publication: Current Neurovascular Research
Volume: 6
Page Numbers: 62-69
External Link: https://doi.org/10.2174/156720209787466046
Delayed rehabilitation lessens brain injury and improves recovery after intracerebral hemorrhage in rats.
Author(s): Auriat, A. and Colbourne, F.
Publication Date: 1/28/2009
Publication: Brain Research
Volume: 1251
Page Numbers: 262-268
External Link: https://doi.org/10.1016/j.brainres.2008.11.038
Cytoprotection strategies for experimental intracerebral hemorrhage (Ch 19).
Author(s): MacLellan, C. L., Peeling, J., and Colbourne, F.
Publication Date: 2009
Page Numbers: 217-228
External Link: https://doi.org/10.1017/CBO9780511691836.020
Progressive injury after collagenase-induced intracerebral hemorrhage in rats.
Author(s): Nguyen, A., Huynh, H., Sjovold, S. and Colbourne, F.
Publication Date: 8/1/2008
Publication: Current Neurovascular Research
Volume: 5
Page Numbers: 171-177
External Link: https://doi.org/10.2174/156720208785425710
Comparison of 12, 24 and 48 hours of systemic hypothermia on outcome after permanent focal ischemia in rat.
Author(s): Clark, D., Penner, M., Orellana-Jordan, I. and Colbourne, F.
Publication Date: 8/1/2008
Publication: Experimental Neurology
Volume: 212
Page Numbers: 386-392
External Link: https://doi.org/10.1016/j.expneurol.2008.04.016
Failure of estradiol to improve spontaneous or rehabilitation-facilitated recovery after hemorrhagic stroke in rats.
Author(s): Nguyen, A., Arvanitidis, A. and Colbourne, F.
Publication Date: 2/8/2008
Publication: Brain Research
Volume: 1193
Page Numbers: 109-119
External Link: https://doi.org/10.1016/j.brainres.2007.11.054
Influence of amphetamine on recovery after hemorrhagic stroke in rat.
Author(s): Auriat, A. and Colbourne, F.
Publication Date: 2/1/2008
Publication: Behavioral Brain Research
Volume: 186
Page Numbers: 222-229
External Link: https://www.researchgate.net/deref/http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.bbr.2007.08.010
Spontaneous temperature changes in the 2-vessel occlusion model of cerebral ischemia in rats.
Author(s): Clark, D., De Butte-Smith, M. and Colbourne, F.
Publication Date: 12/1/2007
Publication: Canadian Journal of Physiology and Pharmacology
Volume: 85
Page Numbers: 1263-1268
External Link: https://doi.org/10.1139/y07-119
The effects of selective brain hypothermia on intracerebral hemorrhage in rats.
Author(s): Fingas, M., Clark, D. and Colbourne, F.
Publication Date: 12/1/2007
Publication: Experimental Neurology
Volume: 208
Page Numbers: 277-284
External Link: https://doi.org/10.1016/j.expneurol.2007.08.018
Intracerebral hemorrhage models in rat: comparing collagenase to blood infusion.
Author(s): MacLellan, C., Silasi, G., Poon, C. L., Edmundson, C., Buist, R., Peeling, J. and Colbourne, F.
Publication Date: 8/29/2007
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 28
Issue: 3
Page Numbers: 516-525
External Link: https://doi.org/10.1038%2Fsj.jcbfm.9600548
Failure of estradiol to ameliorate global ischemia-induced CA1 injury in middle-aged female gerbils.
Author(s): De Butte-Smith, M., Nguyen, A., Zukin, R.S., Etgen, A.M. and Colbourne, F.
Publication Date: 6/11/2007
Publication: Brain Research
Volume: 1153
Page Numbers: 214-220
External Link: https://doi.org/10.1016/j.brainres.2007.03.082
A simple method to induce focal brain hypothermia in rats.
Author(s): Clark, D. and Colbourne, F.
Publication Date: 2007
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 27
Page Numbers: 115-122
External Link: https://doi.org/10.1038/sj.jcbfm.9600327
Skilled reaching impairments follow intrastriatal hemorrhagic stroke in rats.
Author(s): MacLellan, C., Gyawali, S. and Colbourne, F.
Publication Date: 9/7/2006
Publication: Behavioral Brain Research
Volume: 175
Page Numbers: 82-89
External Link: https://doi.org/10.1016/j.bbr.2006.08.001
Forced exercise does not improve recovery after hemorrhagic stroke in rats.
Author(s): Auriat, A., Grams, J., Yan, R. and Colbourne, F.
Publication Date: 9/1/2006
Publication: Brain Research
Volume: 1109
Page Numbers: 183-191
External Link: https://doi.org/10.1016/j.brainres.2006.06.035
Gauging recovery after hemorrhagic stroke in rats: implications for cytoprotection studies.
Author(s): MacLellan, C. L., Auriat, A., McGie, S., Yan, R., Huynh, H, De Butte, M. and Colbourne, F.
Publication Date: 8/1/2006
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 26
Page Numbers: 1031-1042
External Link: https://doi.org/10.1038%2Fsj.jcbfm.9600255
The influence of hypothermia on outcome after intracerebral hemorrhage in rats.
Author(s): MacLellan, C. L., Davies, L., Fingas, M. and Colbourne F.
Publication Date: 3/30/2006
Publication: Stroke
Volume: 37
Page Numbers: 1266-1270
External Link: https://doi.org/10.1161/01.STR.0000217268.81963.78
Increased behavioral and histological variability arising from changes in cerebrovascular anatomy of the Mongolian gerbil.
Author(s): Laidley, D. T., Colbourne, F. and Corbett, D.
Publication Date: 12/1/2005
Publication: Current Neurovascular Research
Volume: 2
Page Numbers: 401-407
External Link: https://doi.org/10.2174/156720205774962719
Combined use of a cytoprotectant and rehabilitation therapy after severe intracerebral hemorrhage in rats.
Author(s): MacLellan, C. L., Grams, J., Adams, K. and Colbourne, F.
Publication Date: 11/23/2005
Publication: Brain Research
Volume: 1063
Page Numbers: 40-47
External Link: https://doi.org/10.1016/j.brainres.2005.09.027
Mild to moderate hyperthermia does not worsen outcome after severe intracerebral hemorrhage in rats.
Author(s): MacLellan, C. L. and Colbourne, F.
Publication Date: 8/1/2005
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 25
Page Numbers: 1020-1029
External Link: https://doi.org/10.1038%2Fsj.jcbfm.9600099
17ß-Estradiol pretreatment reduces bleeding and brain injury after intracerebral hemorrhagic stroke in male rats.
Author(s): Auriat, A., Plahta, W. C., McGie, S., Yan, R. and Colbourne, F.
Publication Date: 2/1/2005
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 25
Page Numbers: 247-256
External Link: https://doi.org/10.1038%2Fsj.jcbfm.9600026
Temperature-regulated model of focal ischemia in the mouse: a study with histopathological and behavioral outcomes.
Author(s): Barber, P. A., Hoyte, L., Colbourne, F. and Buchan, A. M.
Publication Date: 5/20/2004
Publication: Stroke
Volume: 35
Page Numbers: 1720-1725
External Link: https://doi.org/10.1161/01.STR.0000129653.22241.d7
Immediate constraint-induced movement therapy causes hyperthermia that exacerbates cerebral cortical injury in rats.
Author(s): DeBow, S., McKenna, J., Kolb, B. and Colbourne, F.
Publication Date: 4/1/2004
Publication: Canadian Journal of Physiology and Pharmacology
Volume: 82
Page Numbers: 231-237
External Link: https://doi.org/10.1139/y04-013
17ß-Estradiol pretreatment reduces CA1 sector cell death and the spontaneous hyperthermia that follows forebrain ischemia in gerbil.
Author(s): Plahta, W. C., Clark, D. L. and Colbourne, F.
Publication Date: 2004
Publication: Neuroscience
Volume: 129
Page Numbers: 187-193
External Link: https://doi.org/10.1016/j.neuroscience.2004.07.037
Postischemic Hypothermia Provides Long-Term Neuroprotection in Rodents
Author(s): Colbourne, F. and Corbett, D.
Publication Date: 2004
Publication: Hypothermia and Cerebral Ischemia
Page Numbers: 79-81
External Link: https://doi.org/10.1007/978-1-59259-653-9_5
Effects of delayed cooling on a striatal hemorrhagic stroke in rats.
Author(s): MacLellan, C. L., Shuaib, A. and Colbourne, F.
Publication Date: 2004
Publication: Maturation Phenomenon in Cerebral Ischemia V
Page Numbers: 279-284

Incomplete assessment of experimental cytoprotectants in rodent ischemia studies.
Author(s): DeBow, S., Clark, D., MacLellan, C. L. and Colbourne, F.
Publication Date: 11/1/2003
Publication: The Canadian Journal of Neurological Sciences
Volume: 30
Page Numbers: 368-374
External Link: https://doi.org/10.1017/S0317167100003097
Stress induced fever after postischemic rectal temperature measurements in the gerbil.
Author(s): Clark, D., DeBow, S., Iseke, M. and Colbourne, F.
Publication Date: 9/1/2003
Publication: Canadian Journal of Physiology and Pharmacology
Volume: 80
Page Numbers: 880-883
External Link: https://doi.org/10.1139/y03-083
Brain temperature measurement and regulation in awake and freely moving rodents.
Author(s): DeBow S. and Colbourne F.
Publication Date: 6/1/2003
Publication: Methods
Volume: 30
Page Numbers: 167-171
External Link: https://doi.org/10.1016/s1046-2023(03)00080-x
Constraint-induced movement therapy and rehabilitation exercises lessen motor deficits and the volume of brain injury following striatal hemorrhagic stroke in rats.
Author(s): DeBow, S., Davies, M., Clarke, H., Colbourne, F.
Publication Date: 3/20/2003
Publication: Stroke
Volume: 24
Page Numbers: 1021–1026
External Link: https://doi.org/10.1161/01.STR.0000063374.89732.9F
A robust, efficient and flexible method for staining myelinated axons in immersion-fixed brain.
Author(s): Wahlsten, D., Colbourne, F. and Pleus, R.
Publication Date: 3/15/2003
Publication: Journal of Neuroscience Methods
Volume: 123
Page Numbers: 207-214
External Link: https://doi.org/10.1016/S0165-0270(02)00359-X
Hypothermia rescues hippocampal CA1 neurons and attenuates downregulation of the AMPA receptor subunit GluR2 after forebrain ischemia.
Author(s): Colbourne, F. Grooms, S.Y., Zukin, R.S., Buchan A.M. and Bennett M.V.L.
Publication Date: 3/4/2003
Publication: Proceedings of the National Academy of Sciences (U.S.A.)
Volume: 100(5)
Page Numbers: 2906-2910
External Link: https://doi.org/10.1073/pnas.2628027100
Delayed transient ischemic attacks kill some CA1 neurons previously salvaged with postischemic hypothermia: neuroprotection undone.
Author(s): DeBow, S., Colbourne, F.
Publication Date: 1/3/2003
Publication: Brain Research
Volume: 959
Page Numbers: 50-57
External Link: https://doi.org/10.1016/S0006-8993(02)03721-6
Failure of delayed and prolonged hypothermia to favorably affect hemorrhagic stroke in rats.
Author(s): MacLellan, C., Shuaib, A. and Colbourne, F.
Publication Date: 12/20/2002
Publication: Brain Research
Volume: 958
Page Numbers: 192-200
External Link: https://doi.org/10.1016/s0006-8993(02)03702-2
Delayed onset of prolonged hypothermia improves outcome after intracerebral hemorrhage in rats.
Author(s): MacLellan, C. L., Girgis, J. and Colbourne, F.
Publication Date: 4/1/2001
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 24
Page Numbers: 432-440
External Link: https://doi.org/10.1097/00004647-200404000-00008
Electrophysiological properties of CA1 neurons protected by postischemic hypothermia.
Author(s): Dong, H., Moody-Corbett, F., Colbourne, F., Pittman, Q., and Corbett, D.
Publication Date: 3/1/2001
Publication: Stroke
Volume: 32
Page Numbers: 788-795
External Link: https://doi.org/10.1161/01.STR.32.3.788
Prolonged but delayed postischemic hypothermia: a long-term outcome study in the rat middle cerebral artery occlusion model.
Author(s): Colbourne, F., Corbett D., Zhao, Z., Yang, J. and Buchan A.M.
Publication Date: 12/1/2000
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 20
Page Numbers: 1702-1708
External Link: https://doi.org/10.1097%2F00004647-200012000-00009
Persistent neuroprotection with prolonged postischemic hypothermia in adult rats subjected to transient middle cerebral artery occlusion.
Author(s): Corbett, D., Hamilton, M. and Colbourne, F.
Publication Date: 5/1/2000
Publication: Experimental Neurology
Volume: 163
Page Numbers: 200-206
External Link: https://doi.org/10.1006/exnr.2000.7369
Caspase inhibitors reduce ischemic injury following focal but not global cerebral ischemia in rats.
Author(s): Li, H., Colbourne, F., Sun P., Zhao Z.H. and Buchan A.M.
Publication Date: 2000
Publication: Stroke
Volume: 31
Page Numbers: 176-182
External Link: https://doi.org/10.1161/01.STR.31.1.176
Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats.
Author(s): Colbourne, F., Li, H. and Buchan A.M. Indefatigable
Publication Date: 7/1/1999
Publication: Journal of Cerebral
Volume: 19
Page Numbers: 742-749
External Link: https://doi.org/10.1097%2F00004647-199907000-00003
Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia.
Author(s): Colbourne, F., Sutherland, G.R. and Auer, R.N.
Publication Date: 6/1/1999
Publication: Journal of Neuroscience
Volume: 19
Page Numbers: 4200-4210
External Link: https://doi.org/10.1523/jneurosci.19-11-04200.1999
Continuing postischemic neuronal death in CA1 - influence of ischemia duration, and cytoprotective doses of NBQX and SNX-111
Author(s): Colbourne, F., Li, H. and Buchan A.M.
Publication Date: 3/1/1999
Publication: Stroke
Volume: 30
Page Numbers: 662-668
External Link: https://doi.org/10.1161/01.STR.30.3.662
The effects of temperature and scopolamine on N-methyl-D-aspartate antagonist-induced neuronal necrosis in the rat.
Author(s): Colbourne, F., Rakic, D. and Auer, R.N.
Publication Date: 2/1/1999
Publication: Neuroscience
Volume: 90
Page Numbers: 87-94
External Link: https://doi.org/10.1016/S0306-4522(98)00375-3
Hypothermia: depression of tricarboxylic acid cycle flux and evidence for pentose phosphate shunt upregulation
Author(s): Kaibara, T., Sutherland, G.R., Colbourne, F. and Tyson, R.
Publication Date: 2/1/1999
Publication: Journal of Neurosurgery
Volume: 90
Page Numbers: 339-347
External Link: https://doi.org/10.3171/jns.1999.90.2.0339
No morphological evidence of apoptosis following mild to severe episodes of 4-VO ischemia in rats.
Author(s): Colbourne, F., Li, H. and Buchan A.
Publication Date: 1999
Publication: Maturation Phenomenon in Cerebral Ischemia III
Page Numbers: 69-74
External Link: https://link.springer.com/chapter/10.1007/978-3-642-58602-6_9
Behavioral testing does not exacerbate ischemic CA1 damage in gerbils
Author(s): Colbourne, F., Auer, R.N. and Sutherland G.R.
Publication Date: 9/1/1998
Publication: Stroke
Volume: 29
Page Numbers: 1967-1971
External Link: https://doi.org/10.1161/01.STR.29.9.1967
Characterization of postischemic behavioral deficits in gerbils with and without hypothermic neuroprotection.
Author(s): Colbourne, F., Auer, R.N. and Sutherland G.R.
Publication Date: 8/24/1998
Publication: Brain Research
Volume: 803
Page Numbers: 69-78
External Link: https://doi.org/10.1016/S0006-8993(98)00612-X
Hypothermic neuroprotection: a global ischemia study using 18-20 month old gerbils.
Author(s): Corbett, D., Nurse, S.M. and Colbourne, F.
Publication Date: 11/1/1997
Publication: Stroke
Volume: 28
Page Numbers: 2238-2242
External Link: https://doi.org/10.1161/01.str.28.11.2238
Postischemic hypothermia: a critical appraisal with implications for clinical treatment.
Author(s): Colbourne, F., Sutherland, G. and Corbett, D.
Publication Date: 6/1/1997
Publication: Molecular Neurobiology
Volume: 14
Page Numbers: 171-201
External Link: https://doi.org/10.1007/BF02740655
Temperature modulation of ischemic maturation phenomenon.
Author(s): Colbourne, F., Auer, R. N. and Corbett, D.
Publication Date: 1997
Page Numbers: 183-188

An automated system for regulating brain temperature in awake and freely-moving rodents.
Author(s): Colbourne, F., Sutherland, G. and Auer R. N.
Publication Date: 8/1/1996
Publication: Journal of Neuroscience Methods
Volume: 67
Page Numbers: 185-190
External Link: https://doi.org/10.1016/0165-0270(96)00047-7
Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection.
Author(s): Colbourne, F. and Corbett, D.
Publication Date: 11/1/1995
Publication: Journal of Neuroscience
Volume: 15
Page Numbers: 7250-7260
External Link: https://doi.org/10.1523/JNEUROSCI.15-11-07250.1995
Delayed and prolonged postischemic hypothermia is neuroprotective in the gerbil.
Author(s): Colbourne, F. and Corbett, D.
Publication Date: 8/1/1994
Publication: Brain Research
Volume: 654
Page Numbers: 265-272
External Link: https://doi.org/10.1016/0006-8993(94)90488-X
Spontaneous postischemic hyperthermia is not required for severe CA1 ischemic damage in gerbils.
Author(s): Colbourne, F., Nurse, S. M. and Corbett, D.
Publication Date: 9/24/1993
Publication: Brain Research
Volume: 623
Page Numbers: 1-5
External Link: https://doi.org/10.1016/0006-8993(93)90002-5
Temperature changes associated with forebrain ischemia in the gerbil
Author(s): Colbourne, F., Nurse, S. M. and Corbett, D.
Publication Date: 2/1/1993
Publication: Brain Research
Volume: 602
Page Numbers: 264-267
External Link: https://doi.org/10.1016/0006-8993(93)90691-F
Effects of d amphetamine on the recovery of function following cerebral ischemic injury.
Author(s): Colbourne, F. and Corbett, D.
Publication Date: 8/1/1992
Publication: Pharmacology, Biochemistry and Behavior
Volume: 42
Page Numbers: 705-710
External Link: https://www.sciencedirect.com/science/article/pii/009130579290018B