Prolonged Blood-Brain Barrier Injury Occurs After Experimental Intracerebral Hemorrhage and Is Not Acutely Associated with Additional Bleeding
Author(s): Nadeau, C., Dietrich, K., Wilkinson, C., Crawford, A., George, G., Nichol, H. and Colbourne, F.
Publication Date:
2018
Publication: Translational Stroke Research
Acetazolamide mitigates intracranial pressure spikes without affecting functional outcome after experimental hemorrhagic stroke
Author(s): Williamson, M. R., Wilkinson, C. M., Dietrich, K. and Colbourne, F.
Publication Date:
2018
Publication: Translational Stroke Research
Mild contralesional hypothermia reduces use of the unimpaired limb in a skilled reaching task after motor cortex injury in rat.
Author(s): Klahr, A.C., Fagan, K., Aziz, J.R., John, R. and Colbourne, F.
Publication Date:
2018
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 8
Hyperoxia enhances slow-wave forebrain states in urethane anesthetized and naturally sleeping rats
Author(s): Hauer, B. Negash, B., Chan, K., Vuong, W., Colbourne, F., Pagliardini, S, and Dickson, C.
Publication Date:
2018
Publication: Journal of Neurophysiology
N-acetylcysteine blocks ALOX5-induced ferroptosis and synergizes with PGE2 to treat brain hemorrhage
Author(s): Karuppagounder, S. S., Alin, L., Chen, Y., Brand, D. Bourassa, M. W., Dietrich, K., Wilkinson, C., Nadeau, C. A., Perry, S., Pinto, J., Darley-Usmar, V., Sanchez, S., Milne, G. L., Pratico, D., Holman, T. R., Colbourne, F. and Ratan, R. R.
Publication Date:
2018
Publication: Annals of Neurology
Temperature control in rodent neuroprotection studies: methods and challenges.
Author(s): Klahr, A., Nadeau, C. and Colbourne, F.
Publication Date:
2017
Publication: Temperature Control in Rodent Neuroprotection Studies: Methods and Challenges
Volume: 7
Rehabilitation augments hematoma clearance and attenuates oxidative injury and ion dyshomeostasis after brain hemorrhage.
Author(s): Williamson, M.J., Dietrich, K., Hackett, M.J., Caine, S., Nadeau, C., Aziz, J., Nichol, H., Paterson, P.G., and Colbourne, F.
Publication Date:
2017
Publication: Stroke
Volume: 48
Examining potential side effects of therapeutic hypothermia in experimental intracerebral hemorrhage.
Author(s): Wowk, S., Fagan, K., Ma, Y., Nichol, H. and Colbourne, F.
Publication Date:
2017
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 37
Evidence for decreased brain parenchymal volume after large intracerebral hemorrhages: a potential mechanism limiting intracranial pressure rises.
Author(s): Williamson, M.R. and Colbourne, F.
Publication Date:
2017
Publication: Translational Stroke Research
Volume: 8
Delayed localized hypothermia reduces intracranial pressure following collagenase-inducedintracerebral hemorrhage in rat
Author(s): John, R. and Colbourne, F.
Publication Date:
2016
Publication: Brain Research
Volume: 1633
Prolonged Localized Mild Hypothermia Does Not Affect Seizure Activity After Intracerebral Hemorrhage in Rats
Author(s): Klahr, A., Dietrich, K., Dickson, C. and Colbourne, F.
Publication Date:
2016
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 6
Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis
Author(s): Potter, L., Paylor, J., Suh, J., Tenorio, G., Caliaperumal, I., Colbourne, F., Baker, G., Winship, I. and Kerr, B.
Publication Date:
2016
Publication: Journal of Neuroinflammation
Volume: 13
Therapeutic targeting of oxygen-sensing prolyl-hydroxylase domain enzymes abrogates atf4-dependent death and improves outcomes from brain hemorrhage.
Author(s): Karuppagounder, S.S., Alim, I., Khim S.J., Bourassa, M.W., Sleiman, S.F., John, R.F., Thinnes, C.C., Yeh, T.-L., Demetriades, M., Neitemeier, S., Cruz, D., Gazaryan, I., Killilea, D., Morgenstern, L., Xi, G.H., Keep, R.F., Schallert, T., Tappero, R.V., Zhong, J., Cho, S., Maxfield, F.R., Holman, T.R., Culmsee, C., Fong, G.H., Cave, J., Schofield, C.J., Colbourne, F., Coppola, G., Ratan, R.R
Publication Date:
2016
Publication: Science Translation Medicine
Volume: 8
Therapeutic hypothermia fails to mitigate iron-induced injury in rat
Author(s): Wowk, S., Ma, Y. and Colbourne, F.
Publication Date:
2016
Publication: Therapeutic Hypothermia and Temperature Management.
Volume: 6
Seizure activity occurs in the collagenase but not the blood infusion model of striatal hemorrhagic stroke in rats.
Author(s): Klahr, A., Dickson, C. and Colbourne, F.
Publication Date:
2015
Publication: Translational Stroke Research
Volume: 6
Localized hypothermia aggravates bleeding in the collagenase model of intracerebral hemorrhage.
Author(s): John, R., Williamson, M., Dietrich, K. and Colbourne, F.
Publication Date:
2014
Publication: Therapeutic Hypothermia and Temperature Management
Mild hypothermia does not reduce thrombin-induced brain injury.
Author(s): Wowk, S., Ma, Y. and Colbourne F.
Publication Date:
2014
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 4
Unilateral brain hypothermia as a method to examine efficacy and mechanisms of neuroprotection against global ischemia.
Author(s): Silasi, G. and Colbourne, F.
Publication Date:
2011
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 1
Transient global cerebral ischemia produces morphologically necrotic, not apoptotic neurons.
Author(s): Colbourne, F. and Auer, R.
Publication Date:
2010
Cytoprotection strategies for experimental intracerebral hemorrhage (Ch 19).
Author(s): MacLellan, C. L., Peeling, J., and Colbourne, F.
Publication Date:
2009
17ß-Estradiol pretreatment reduces CA1 sector cell death and the spontaneous hyperthermia that follows forebrain ischemia in gerbil.
Author(s): Plahta, W. C., Clark, D. L. and Colbourne, F.
Publication Date:
2004
Publication: Neuroscience
Volume: 129
Postischemic Hypothermia Provides Long-Term Neuroprotection in Rodents
Author(s): Colbourne, F. and Corbett, D.
Publication Date:
2004
Effects of delayed cooling on a striatal hemorrhagic stroke in rats.
Author(s): MacLellan, C. L., Shuaib, A. and Colbourne, F.
Publication Date:
2004
Page Numbers: 279-284
No morphological evidence of apoptosis following mild to severe episodes of 4-VO ischemia in rats.
Author(s): Colbourne, F., Li, H. and Buchan A.
Publication Date:
1999
Page Numbers: 69-74
Temperature modulation of ischemic maturation phenomenon.
Author(s): Colbourne, F., Auer, R. N. and Corbett, D.
Publication Date:
1997
Page Numbers: 183-188
Effects of d-amphetamine on the recovery of function following cerebral ischemic injury.
Author(s): Colbourne, F. and Corbett, D.
Publication: Pharmacology, Biochemistry and Behavior
Volume: 42
Spontaneous postischemic hyperthermia is not required for severe CA1 ischemic damage in gerbils.
Author(s): Colbourne, F., Nurse, S. M. and Corbett, D.
Publication: Brain Research
Volume: 623
Temperature changes associated with forebrain ischemia in the gerbil.
Author(s): Colbourne, F., Nurse, S. M. and Corbett, D.
Publication: Brain Research
Volume: 602
Delayed and prolonged postischemic hypothermia is neuroprotective in the gerbil.
Author(s): Colbourne, F. and Corbett, D.
Publication: Brain Research
Volume: 654
Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection.
Author(s): Colbourne, F. and Corbett, D.
Publication: Journal of Neuroscience
Volume: 15
An automated system for regulating brain temperature in awake and freely-moving rodents.
Author(s): Colbourne, F., Sutherland, G. and Auer R. N.
Publication: Journal of Neuroscience Methods
Volume: 67
Hypothermic neuroprotection: a global ischemia study using 18-20 month old gerbils.
Author(s): Corbett, D., Nurse, S.M. and Colbourne, F.
Publication: Stroke
Volume: 28
Colbourne, F., Sutherland, G. and Corbett, D.
Author(s): Postischemic hypothermia: a critical appraisal with implications for clinical treatment.
Publication: Molecular Neurobiology
Volume: 14
Characterization of postischemic behavioral deficits in gerbils with and without hypothermic neuroprotection.
Author(s): Colbourne, F., Auer, R.N. and Sutherland G.R.
Publication: Brain Research
Volume: 803
Behavioral testing does not exacerbate ischemic CA1 damage in gerbils
Author(s): Colbourne, F., Auer, R.N. and Sutherland G.R.
Publication: 29
Volume: Stroke
Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia.
Author(s): Colbourne, F., Sutherland, G.R. and Auer, R.N.
Publication: Journal of Neuroscience
Volume: 19
Continuing postischemic neuronal death in CA1 - influence of ischemia duration, and cytoprotective doses of NBQX and SNX-111
Author(s): Colbourne, F., Li, H. and Buchan A.M.
Publication: Stroke
Volume: 30
Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats.
Author(s): Colbourne, F., Li, H. and Buchan A.M. Indefatigable
Publication: Journal of Cerebral
Volume: 19
The effects of temperature and scopolamine on N-methyl-D-aspartate antagonist-induced neuronal necrosis in the rat.
Author(s): Colbourne, F., Rakic, D. and Auer, R.N.
Publication: Neuroscience
Volume: 90
Hypothermia: depression of TCA cycle flux and evidence for pentose phosphate shunt upregulation
Author(s): Kaibara, T., Sutherland, G.R., Colbourne, F. and Tyson, R.
Publication: Journal of Neurosurgery
Volume: 90
Prolonged but delayed postischemic hypothermia: a long-term outcome study in the rat middle cerebral artery occlusion model.
Author(s): Colbourne, F., Corbett D., Zhao, Z., Yang, J. and Buchan A.M.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 20
Persistent neuroprotection with prolonged postischemic hypothermia in adult rats subjected to transient middle cerebral artery occlusion.
Author(s): Corbett, D., Hamilton, M. and Colbourne, F.
Publication: Experimental Neurology
Volume: 163
Caspase inhibitors reduce ischemic injury following focal but not global cerebral ischemia in rats.
Author(s): Li, H., Colbourne, F., Sun P., Zhao Z.H. and Buchan A.M.
Publication: Stroke
Volume: 31
Electrophysiological properties of CA1 neurons protected by postischemic hypothermia.
Author(s): Dong, H., Moody-Corbett, F., Colbourne, F., Pittman, Q., and Corbett, D.
Publication: Stroke
Volume: 32
Failure of delayed and prolonged hypothermia to favorably affect hemorrhagic stroke in rats.
Author(s): MacLellan, C., Shuaib, A. and Colbourne, F.
Publication: Brain Research
Volume: 958
Incomplete assessment of experimental cytoprotectants in rodent ischemia studies.
Author(s): DeBow, S., Clark, D., MacLellan, C. L. and Colbourne, F.
Publication: The Canadian Journal of Neurological Sciences
Volume: 30
Stress induced fever after postischemic rectal temperature measurements in the gerbil.
Author(s): Clark, D., DeBow, S., Iseke, M. and Colbourne, F.
Publication: Canadian Journal of Physiology and Pharmacology
Volume: 80
Brain temperature measurement and regulation in awake and freely moving rodents.
Author(s): DeBow S. and Colbourne F.
Publication: Methods
Volume: 30
Constraint-induced movement therapy and rehabilitation exercises lessen motor deficits and the volume of brain injury following striatal hemorrhagic stroke in rats.
Author(s): DeBow, S., Davies, M., Clarke, H., Colbourne, F.
Publication: Stroke
Volume: 24
Hypothermia rescues hippocampal CA1 neurons and attenuates downregulation of the AMPA receptor subunit GluR2 after forebrain ischemia.
Author(s): Colbourne, F. Grooms, S.Y., Zukin, R.S., Buchan A.M. and Bennett M.V.L.
Publication: Proceedings of the National Academy of Sciences (U.S.A.)
Volume: 100(5)
A robust, efficient and flexible method for staining myelinated axons in immersion-fixed brain.
Author(s): Wahlsten, D., Colbourne, F. and Pleus, R.
Publication: Journal of Neuroscience Methods
Volume: 123
Delayed transient ischemic attacks kill some CA1 neurons previously salvaged with postischemic hypothermia: neuroprotection undone.
Author(s): DeBow, S., Colbourne, F.
Publication: Brain Research
Volume: 959
Postischemic diazepam does not reduce hippocampal CA1 injury and does not improve hypothermic neuroprotection
Author(s): Davies, L., MacLellan, C., Corbett, D. and Colbourne, F.
Publication: Brain Research
Volume: 1013
Temperature-regulated model of focal ischemia in the mouse: a study with histopathological and behavioral outcomes.
Author(s): Barber, P. A., Hoyte, L., Colbourne, F. and Buchan, A. M.
Publication: Stroke
Immediate constraint-induced movement therapy causes hyperthermia that exacerbates cerebral cortical injury in rats.
Author(s): DeBow, S., McKenna, J., Kolb, B. and Colbourne, F.
Publication: Canadian Journal of Physiology and Pharmacology
Delayed onset of prolonged hypothermia improves outcome after intracerebral hemorrhage in rats.
Author(s): MacLellan, C. L., Girgis, J. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 24
ncreased behavioral and histological variability arising from changes in cerebrovascular anatomy of the Mongolian gerbil.
Author(s): Laidley, D. T., Colbourne, F. and Corbett, D.
Publication: Current Neurovascular Research
Volume: 2
Combined use of a cytoprotectant and rehabilitation therapy after severe intracerebral hemorrhage in rats.
Author(s): MacLellan, C. L., Grams, J., Adams, K. and Colbourne, F.
Publication: Brain Research
Volume: 1063
Mild to moderate hyperthermia does not worsen outcome after severe intracerebral hemorrhage in rats.
Author(s): MacLellan, C. L. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 25
17ß-Estradiol pretreatment reduces bleeding and brain injury after intracerebral hemorrhagic stroke in male rats.
Author(s): Auriat, A., Plahta, W. C., McGie, S., Yan, R. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 25
killed reaching impairments follow intrastriatal hemorrhagic stroke in rats.
Author(s): MacLellan, C., Gyawali, S. and Colbourne, F.
Publication: Behavioral Brain Research
Volume: 175
Forced exercise does not improve recovery after hemorrhagic stroke in rats.
Author(s): Auriat, A., Grams, J., Yan, R. and Colbourne, F.
Publication: Brain Research
Volume: 1109
The influence of hypothermia on outcome after intracerebral hemorrhage in rats.
Author(s): MacLellan, C. L., Davies, L., Fingas, M. and Colbourne F.
Publication: Stroke
Volume: 37
Gauging recovery after hemorrhagic stroke in rats: implications for cytoprotection studies.
Author(s): MacLellan, C. L., Auriat, A., McGie, S., Yan, R., Huynh, H, De Butte, M. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 26
Temperature changes associated with 2-VO ischemia in rats.
Author(s): Clark, D., De Butte-Smith, M. and Colbourne, F.
Publication: Canadian Journal of Physiology and Pharmacology
Volume: 85
The effects of selective brain hypothermia on intracerebral hemorrhage in rats.
Author(s): Fingas, M., Clark, D. and Colbourne, F.
Publication: Experimental Neurology
Volume: 208
Failure of estradiol to ameliorate global ischemia-induced CA1 injury in middle-aged female gerbils.
Author(s): De Butte-Smith, M., Nguyen, A., Zukin, R.S., Etgen, A.M. and Colbourne, F.
Publication: Brain Research
Volume: 1153
A simple method to induce focal brain hypothermia in rats.
Author(s): Clark, D. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 27
Progressive injury after collagenase-induced intracerebral hemorrhage in rats.
Author(s): Nguyen, A., Huynh, H., Sjovold, S. and Colbourne, F.
Publication: Current Neurovascular Research
Volume: 5
Comparison of 12, 24 and 48 hours of systemic hypothermia on outcome after permanent focal ischemia in rat.
Author(s): Clark, D., Penner, M., Orellana-Jordan, I. and Colbourne, F.
Publication: Experimental Neurology
Volume: 212
Failure of estradiol to improve spontaneous or rehabilitation-facilitated recovery after hemorrhagic stroke in rats.
Author(s): Nguyen, A., Arvanitidis, A. and Colbourne, F.
Publication: Brain Research
Volume: 1193
Influence of amphetamine on recovery after hemorrhagic stroke in rat.
Author(s): Auriat, A. and Colbourne, F.
Publication: Behavioral Brain Research
Volume: 186
Intracerebral hemorrhage models in rat: comparing collagenase to blood infusion.
Author(s): MacLellan, C., Silasi, G., Poon, C. L., Edmundson, C., Buist, R., Peeling, J. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 28
Issue: 28
Treatments (12 and 48 h) with systemic and brain-selective hypothermia techniques after permanent focal cerebral ischemia in rat.
Author(s): Clark, D., Penner, M., Wowk, S., Orellana-Jordan, I. and Colbourne, F.
Publication: Experimental Neurology
Volume: 220
Treatment of intracerebral hemorrhage in rats with 12 h, 3 days and 6 days of selective brain hypothermia.
Author(s): Fingas, M., Penner, M., Silasi, G. and Colbourne, F.
Publication: Experimental Neurology
Volume: 219
Use of telemetry blood pressure transmitters to measure intracranial pressure (ICP) in freely moving rats.
Author(s): Silasi, G., MacLellan, C. and Colbourne, F.
Publication: Current Neurovascular Research
Volume: 6
A high fat diet does not exacerbate CA1 injury and cognitive deficits following global ischemia in rats.
Author(s): Arvanitidis, A., Corbett, D. and Colbourne, F.
Publication: Brain Research
Volume: 1252
Delayed rehabilitation lessens brain injury and improves recovery after intracerebral hemorrhage in rats.
Author(s): Auriat, A. and Colbourne, F.
Publication: Brain Research
Volume: 1251
Long-term assessment of motor and cognitive behaviors in the intraluminal perforation model of subarachnoid hemorrhage in rats.
Author(s): Silasi, G. and Colbourne, F.
Publication: Behavioral Brain Research
Volume: 198
Use of prolonged hypothermia to treat ischemic and hemorrhagic stroke.
Author(s): MacLellan, C. L., Clark, D. L., Silasi, G and Colbourne, F.
Publication: Journal of Neurotrauma
Volume: 26
Rodent models of intracerebral hemorrhage.
Author(s): MacLellan, C., Silasi, G., Auriat, A. and Colbourne, F.
Publication: Stroke
Volume: 41[suppl 1]
Secondary damage in the spinal cord following motor cortex injury in rats.
Author(s): Weishaupt, N., Silasi, G., Colbourne, F. and Fouad, K.
Publication: Journal of Neurotrauma
Volume: 27
Rehabilitation after intracerebral hemorrhage in rats improves recovery with enhanced dendritic complexity but no effect on cell proliferation.
Author(s): Auriat, A., Wowk, S. and Colbourne, F.
Publication: Behavioral Brain Research
Volume: 214
Failure of deferoxamine, an iron chelator, to improve outcome after collagenase-induced intracerebral hemorrhage in rats.
Author(s): Warkentin, L., Auriat, A., Wowk, S. and Colbourne, F.
Publication: Brain Research
Volume: 1309
Therapeutic hypothermia influences cell genesis and survival in the rat hippocampus following global ischemia.
Author(s): Silasi, G. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 31
Rehabilitation promotes recovery after whole-blood induced intracerebral hemorrhage in rats
Author(s): MacLellan, C. L., Plummer, N., Silasi, G., Auriat, A.M. and Colbourne, F.
Publication: Neurorehabilitation and Neural Repair
Volume: 25
Brief hyperthermia does not worsen outcome after striatal hemorrhage in rats
Author(s): Penner, M., Silasi, G., Wowk, S, Warkentin, L., Colbourne, F.
Publication: Current Neurovascular Research
Volume: 8
Protein energy malnutrition alters thermoregulatory homeostasis and the response to brain ischemia
Author(s): Smith, S.E., Prosser-Loose, E.J., Colbourne, F. and Paterson, P.G.
Publication: Current Neurovascular Research
Volume: 8
Intraparenchymal ferrous iron infusion causes neuronal atrophy, cell death and progressive tissue loss: implications for intracerebral hemorrhage
Author(s): Caliaperumal, J., Ma, Y. and Colbourne, F.
Publication: Experimental Neurology
Volume: 15
Prolonged Hypothermia in Rat: A Safety Study Using Brain-Selective and Systemic Treatments
Author(s): Auriat, A., Klahr, A., Silasi, G., MacLellan, C., Penner, M., Clark, D. and Colbourne, F.
Publication: Therapeutic Hypothermia and Temperature Management
Volume: 2
Prolonged therapeutic hypothermia does not adversely impact neuroplasticity after global ischemia in rats
Author(s): Silasi, G., Klahr, A., Hackett, M., Auriat, A., Nichol, H. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 32
A critical appraisal of experimental intracerebral hemorrhage research
Author(s): MacLellan, C., Paquette, R. and Colbourne, F.
Publication: Journal of Cerebral Blood Flow and Metabolism
Volume: 32
Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome
Author(s): Auriat, A., Silasi, G., Wei, Z., Paquette, R., Paterson, P., Nichol, H. and Colbourne, F.
Publication: Experimental Neurology
Volume: 234
Bipyridine, an iron chelator, does not lessen intracerebral iron-induced damage or improve outcome after intracerebral hemorrhagic stroke in rats
Author(s): Caliaperumal, J., Wowk, S., Jones, S., Ma, Y. and Colbourne, F.
Publication: Translational Stroke Research
Volume: 4
Thrombin causes neuronal atrophy and acute but not chronic cell death.
Author(s): Caliaperumal, J., Brodie, S., Ma, Y. and Colbourne, F.
Intracranial pressure measured in freely moving rats for days after intracerebral hemorrhage
Author(s): Hiploylee, C. and Colbourne, F.
Publication: Experimental Neurology
Volume: 255
Rehabilitation improves behavioral recovery and lessens cell death without affecting iron, ferritin, transferrin or inflammation after intracerebral hemorrhage in rats
Author(s): Caliaperumal, J. and Colbourne, F.
Publication: Neurorehabilitation and Neural Repair
Volume: 28
A New Method To Image Heme-Fe, Total Fe, and Aggregated Protein Levels after Intracerebral Hemorrhage
Author(s): Hackett, M., DeSouza, M., Caine, S., Bewer, B.,Nichol, H., Paterson, P. and Colbourne, F.
Publication: ACS Chemical Neuroscience