Contact
Professor, Faculty of Medicine & Dentistry - Pharmacology Dept
- pem@ualberta.ca
- Address
-
6-126C Li Ka Shing Centre For Research
8602 112 St NWEdmonton ABT6G 2E1
Overview
Area of Study / Keywords
diabetes metabolomics tissue bank genetics toxicology
About
Prof. Patrick MacDonald is currently appointed as Professor in the Department of Pharmacology in the Faculty of Medicine & Dentistry.Featured Publications
Skovsø S., Panzhinskiy E., Kolic J., Cen H.H., Dionne D.A., Dai X.Q., Sharma R.B., Elghazi L., Ellis C.E., Faulkner K., Marcil S.A.M., Overby P., Noursadeghi N., Hutchinson D., Hu X., Li H., Modi H., Wildi J.S., Botezelli J.D., Noh H.L., Suk S., Gablaski B., Bautista A., Kim R., Cras-Méneur C., Flibotte S., Sinha S., Luciani D.S., Nislow C., Rideout E.J., Cytrynbaum E.N., Kim J.K., Bernal-Mizrachi E., Alonso L.C., MacDonald P.E., Johnson J.D.
Nature Communications. 2022 December; 13 (1) 10.1038/s41467-022-28039-8
Sto�er A., �terk M., Paradi� Leitgeb E., Markovic R., Skelin Klemen M., Ellis C.E., Kri�ancic Bombek L., Dolen�ek J., MacDonald P.E., Gosak M.
Frontiers in Endocrinology. 2022 June; 13 10.3389/fendo.2022.922640
Dai X.Q., Camunas-Soler J., Briant L.J.B., dos Santos T., Spigelman A.F., Walker E.M., Arrojo e Drigo R., Bautista A., Jones R.C., Avrahami D., Lyon J., Nie A., Smith N., Zhang Y., Johnson J., Manning Fox J.E., Michelakis E.D., Light P.E., Kaestner K.H., Kim S.K., Rorsman P., Stein R.W., Quake S.R., MacDonald P.E.
Cell Metabolism. 2022 February; 34 (2):256-268.e5 10.1016/j.cmet.2021.12.021
Marcheva B., Weidemann B.J., Taguchi A., Perelis M., Ramsey K.M., Newman M.V., Kobayashi Y., Omura C., Fox J.E.M., Lin H., Macdonald P.E., Bass J.
eLife. 2022 February; 11 10.7554/ELIFE.75132
Marquez-Curtis L.A., Dai X.Q., Hang Y., Lam J.Y., Lyon J., Manning Fox J.E., McGann L.E., MacDonald P.E., Kim S.K., Elliott J.A.W.
PLoS One. 2022 January; 17 (1 January) 10.1371/journal.pone.0263005
Dafoe T.J., Dos Santos T., Spigelman A.F., Lyon J., Smith N., Bautista A., MacDonald P.E., Manning Fox J.E.
Islets. 2022 January; 14 (1):101-113 10.1080/19382014.2022.2047571
Wang S., Flibotte S., Camunas-Soler J., MacDonald P.E., Johnson J.D.
Canadian Journal of Diabetes. 2021 December; 45 (8):775-784.e2 10.1016/j.jcjd.2021.03.007
Bevacqua R.J., Dai X., Lam J.Y., Gu X., Friedlander M.S.H., Tellez K., Miguel-Escalada I., Bonàs-Guarch S., Atla G., Zhao W., Kim S.H., Dominguez A.A., Qi L.S., Ferrer J., MacDonald P.E., Kim S.K.
Nature Communications. 2021 December; 12 (1) 10.1038/s41467-021-22651-w
Molecular Mechanisms of Genetic Risk for Type 2 Diabetes: A Focus on ZMIZ1
ADI Research Day 2020. 2021 November;
Kim A., Knudsen J.G., Madara J.C., Benrick A., Hill T., Kadir L.A., Kellard J.A., Mellander L., Miranda C., Lin H., James T., Suba K., Spigelman A.F., Wu Y., Macdonald P.E., Asterholm I.W., Magnussen T., Christensen M., Visboll T., Salem V., Knop F.K., Rorsman P., Lowell B.B., Briant L.J.B.
eLife. 2021 November; 10 10.7554/eLife.72919
Lin H., Smith N., Spigelman A.F., Suzuki K., Ferdaoussi M., Alghamdi T.A., Lewandowski S.L., Jin Y., Bautista A., Wang Y.W., Manning Fox J.E., Merrins M.J., Buteau J., MacDonald P.E.
DIABETES. 2021 November; 70 (11):2626-2638 10.2337/db20-1235
Shrestha S., Saunders D.C., Walker J.T., Camunas-Soler J., Dai X.Q., Haliyur R., Aramandla R., Poffenberger G., Prasad N., Bottino R., Stein R., Cartailler J.P., Parker S.C.J., MacDonald P.E., Levy S.E., Powers A.C., Brissova M.
JCI Insight. 2021 September; 6 (18) 10.1172/jci.insight.151621
Islet cell subpopulations expressing different marker genes show variations in membrane excitability properties
Human Islet Research Network 2021 Virtual Annual Investigator Meeting. 2021 September;
Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SCJ, MacDonald PE, Levy SE, Powers AC, Brissova M
JCI Insight. 2021 August; 6 (18):e151621 10.1101/2021.02.23.432522
Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Jin Y, Bautista A, Wang YW, Manning Fox JE, Buteau J, MacDonald PE
DIABETES. 2021 August; 70 (9) 10.2337/db20-1235
Modelling of Electrical Fingerprints Reveals Transcriptomic Profiles Linked to a-Cell Dysfunction in Type 2 Diabetes
Human Islet Research Network 2021 Virtual Annual Investigator Meeting. 2021 July;
Excitability properties of human islet cell subpopulations expressing distinct transcriptomic marker genes
CIRTN-R2FIC Journal Club. 2021 June;
Glycine Receptor Signaling in Human Pancreatic Islets
Pharmacology Research Day 2021. 2021 May;
Linking Cell Function and Gene Expression to Define Maturation of Stem-Cell Derived �-Cells for the treatment of Type 1 Diabetes
Pharmacology Research Day 2021. 2021 May;
Modelling of Electrical Fingerprints Reveals Transcriptomic Profiles Linked to a-Cell Dysfunction in Type 2 Diabetes
Pharmacology Research Day 2021. 2021 May;
Wang S., Flibotte S., Camunas-Soler J., MacDonald P.E., Johnson J.D.
Canadian Journal of Diabetes. 2021 April; 10.1016/j.jcjd.2021.03.007
Upregulation of cystolic reducing signaling through SENP1 is required for beta-cell functional compensation to short-term high fat diet
The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;
Modelling of Electrical Fingerprints Reveals Transcriptomic Profiles Linked to Alpha Cell Dysfunction in Type 2 Diabetes
The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;
Dai XQ, Camunas-Soler J, Briant LJB, dos Santos T, Spigelman AF, Walker EM, Arrojo e Drigo R, Bautista A, Jones RC, Lyon J, Nie A, Smith N, Manning Fox JE, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE
BioRxiv. 2021 April; 10.1101/2021.04.08.435504
Bevacqua R.J., Dai X., Lam J.Y., Gu X., Friedlander M.S.H., Tellez K., Miguel-Escalada I., Bonàs-Guarch S., Atla G., Zhao W., Kim S.H., Dominguez A.A., Qi L.S., Ferrer J., MacDonald P.E., Kim S.K.
Nature Communications. 2021 April; 12 (1) 10.1038/s41467-021-22651-w
Loss of the Diabetes Risk Gene ZMIZ1 Impairs Insulin Secretion and Beta-Cell Function
The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;
Müller J.A., Groß R., Conzelmann C., Krüger J., Merle U., Steinhart J., Weil T., Koepke L., Bozzo C.P., Read C., Fois G., Eiseler T., Gehrmann J., van Vuuren J., Wessbecher I.M., Frick M., Costa I.G., Breunig M., Grüner B., Peters L., Schuster M., Liebau S., Seufferlein T., Stenger S., Stenzinger A., MacDonald P.E., Kirchhoff F., Sparrer K.M.J., Walther P., Lickert H., Barth T.F.E., Wagner M., Münch J., Heller S., Kleger A.
Nature Metabolism. 2021 February; 3 (2):149-165 10.1038/s42255-021-00347-1
Nalbach L., Roma L.P., Schmitt B.M., Becker V., Körbel C., Wrublewsky S., Pack M., Später T., Metzger W., Menger M.M., Frueh F.S., Götz C., Lin H., EM Fox J., MacDonald P.E., Menger M.D., Laschke M.W., Ampofo E.
EMBO Molecular Medicine. 2021 January; 13 (1) 10.15252/emmm.202012616
dos Santos T., MacDonald P.E.
Islets. 2021 January; 13 (3-4):80-83 10.1080/19382014.2021.1914507
Armour S.L., Anderson S.J., Richardson S.J., Ding Y., Carey C., Lyon J., Maheshwari R.R., Al-Jahdami N., Krasnogor N., Morgan N.G., MacDonald P., Shaw J.A.M., White M.G.
ENDOCRINOLOGY. 2021 January; 161 (4):1-10 10.1210/ENDOCR/BQAA011
Glycine Receptor Signaling in Human Pancreatic Islets
ADI-HRD Symposium 2020. 2020 December;
Exploring Alpha Cell Heterogeneity Through Multi- Dimensional Approaches
ADI-HRD Symposium 2020. 2020 December;
Beta-Cell-Specific Ablation of SENP1 Worsens Oral Glucose Tolerance After Long-Term High Fat Diet
ADI Research Day 2020. 2020 November;
Exploring Alpha-Cell Heterogeneity Through Multi-Synthesis in Lipid Metabolism
ADI Research Day 2020. 2020 November;
Glycine Receptor Signaling in Human Pancreatic Islets
ADI Research Day 2020. 2020 November;
Expression of Distinct Transcriptomic Marker Genes Influence Electrophysiological Properties of Human Islet Cells
ADI Research Day 2020. 2020 November;
Nalbach L., Roma L.P., Schmitt B.M., Becker V., Körbel C., Wrublewsky S., Pack M., Später T., Metzger W., Menger M.M., Frueh F.S., Götz C., Lin H., EM Fox J., MacDonald P.E., Menger M.D., Laschke M.W., Ampofo E.
EMBO Molecular Medicine. 2020 November; 13 (1):e12616 10.15252/emmm.202012616
Molecular Mechanisms of Genetic Risk for Type 2 Diabetes: A Focus on ZMIZ1
ADI Research Day 2020. 2020 November;
Exploring Alpha Cell Heterogeneity Through Multi- Dimensional Approaches
Deutsches Zentrum für Diabetesforschung Diabetes Research School. 2020 October;
Expression of distinct transcriptomic marker genes influence electrophysiological properties of human islet cells
Human Islet Research Network 2020 Virtual Annual Investigator Meeting. 2020 October;