Patrick MacDonald

Professor, Faculty of Medicine & Dentistry - Pharmacology Dept

Contact

Professor, Faculty of Medicine & Dentistry - Pharmacology Dept
Email
pem@ualberta.ca
Address
6-126C Li Ka Shing Centre For Research
8602 112 St NW
Edmonton AB
T6G 2E1

Overview

Area of Study / Keywords

diabetes metabolomics tissue bank genetics toxicology


About

Prof. Patrick MacDonald is currently appointed as Professor in the Department of Pharmacology in the Faculty of Medicine & Dentistry.

Featured Publications

Skovsø S., Panzhinskiy E., Kolic J., Cen H.H., Dionne D.A., Dai X.Q., Sharma R.B., Elghazi L., Ellis C.E., Faulkner K., Marcil S.A.M., Overby P., Noursadeghi N., Hutchinson D., Hu X., Li H., Modi H., Wildi J.S., Botezelli J.D., Noh H.L., Suk S., Gablaski B., Bautista A., Kim R., Cras-Méneur C., Flibotte S., Sinha S., Luciani D.S., Nislow C., Rideout E.J., Cytrynbaum E.N., Kim J.K., Bernal-Mizrachi E., Alonso L.C., MacDonald P.E., Johnson J.D.

Nature Communications. 2022 December; 13 (1) 10.1038/s41467-022-28039-8


Sto�er A., �terk M., Paradi� Leitgeb E., Markovic R., Skelin Klemen M., Ellis C.E., Kri�ancic Bombek L., Dolen�ek J., MacDonald P.E., Gosak M.

Frontiers in Endocrinology. 2022 June; 13 10.3389/fendo.2022.922640


Dai X.Q., Camunas-Soler J., Briant L.J.B., dos Santos T., Spigelman A.F., Walker E.M., Arrojo e Drigo R., Bautista A., Jones R.C., Avrahami D., Lyon J., Nie A., Smith N., Zhang Y., Johnson J., Manning Fox J.E., Michelakis E.D., Light P.E., Kaestner K.H., Kim S.K., Rorsman P., Stein R.W., Quake S.R., MacDonald P.E.

Cell Metabolism. 2022 February; 34 (2):256-268.e5 10.1016/j.cmet.2021.12.021


Marcheva B., Weidemann B.J., Taguchi A., Perelis M., Ramsey K.M., Newman M.V., Kobayashi Y., Omura C., Fox J.E.M., Lin H., Macdonald P.E., Bass J.

eLife. 2022 February; 11 10.7554/ELIFE.75132


Marquez-Curtis L.A., Dai X.Q., Hang Y., Lam J.Y., Lyon J., Manning Fox J.E., McGann L.E., MacDonald P.E., Kim S.K., Elliott J.A.W.

PLoS One. 2022 January; 17 (1 January) 10.1371/journal.pone.0263005


Dafoe T.J., Dos Santos T., Spigelman A.F., Lyon J., Smith N., Bautista A., MacDonald P.E., Manning Fox J.E.

Islets. 2022 January; 14 (1):101-113 10.1080/19382014.2022.2047571


Wang S., Flibotte S., Camunas-Soler J., MacDonald P.E., Johnson J.D.

Canadian Journal of Diabetes. 2021 December; 45 (8):775-784.e2 10.1016/j.jcjd.2021.03.007


Bevacqua R.J., Dai X., Lam J.Y., Gu X., Friedlander M.S.H., Tellez K., Miguel-Escalada I., Bonàs-Guarch S., Atla G., Zhao W., Kim S.H., Dominguez A.A., Qi L.S., Ferrer J., MacDonald P.E., Kim S.K.

Nature Communications. 2021 December; 12 (1) 10.1038/s41467-021-22651-w


Molecular Mechanisms of Genetic Risk for Type 2 Diabetes: A Focus on ZMIZ1

ADI Research Day 2020. 2021 November;


Kim A., Knudsen J.G., Madara J.C., Benrick A., Hill T., Kadir L.A., Kellard J.A., Mellander L., Miranda C., Lin H., James T., Suba K., Spigelman A.F., Wu Y., Macdonald P.E., Asterholm I.W., Magnussen T., Christensen M., Visboll T., Salem V., Knop F.K., Rorsman P., Lowell B.B., Briant L.J.B.

eLife. 2021 November; 10 10.7554/eLife.72919


Lin H., Smith N., Spigelman A.F., Suzuki K., Ferdaoussi M., Alghamdi T.A., Lewandowski S.L., Jin Y., Bautista A., Wang Y.W., Manning Fox J.E., Merrins M.J., Buteau J., MacDonald P.E.

DIABETES. 2021 November; 70 (11):2626-2638 10.2337/db20-1235


Shrestha S., Saunders D.C., Walker J.T., Camunas-Soler J., Dai X.Q., Haliyur R., Aramandla R., Poffenberger G., Prasad N., Bottino R., Stein R., Cartailler J.P., Parker S.C.J., MacDonald P.E., Levy S.E., Powers A.C., Brissova M.

JCI Insight. 2021 September; 6 (18) 10.1172/jci.insight.151621


Islet cell subpopulations expressing different marker genes show variations in membrane excitability properties

Human Islet Research Network 2021 Virtual Annual Investigator Meeting. 2021 September;


Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SCJ, MacDonald PE, Levy SE, Powers AC, Brissova M

JCI Insight. 2021 August; 6 (18):e151621 10.1101/2021.02.23.432522


Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Jin Y, Bautista A, Wang YW, Manning Fox JE, Buteau J, MacDonald PE

DIABETES. 2021 August; 70 (9) 10.2337/db20-1235


Modelling of Electrical Fingerprints Reveals Transcriptomic Profiles Linked to a-Cell Dysfunction in Type 2 Diabetes

Human Islet Research Network 2021 Virtual Annual Investigator Meeting. 2021 July;


Excitability properties of human islet cell subpopulations expressing distinct transcriptomic marker genes

CIRTN-R2FIC Journal Club. 2021 June;


Glycine Receptor Signaling in Human Pancreatic Islets

Pharmacology Research Day 2021. 2021 May;


Linking Cell Function and Gene Expression to Define Maturation of Stem-Cell Derived �-Cells for the treatment of Type 1 Diabetes

Pharmacology Research Day 2021. 2021 May;


Modelling of Electrical Fingerprints Reveals Transcriptomic Profiles Linked to a-Cell Dysfunction in Type 2 Diabetes

Pharmacology Research Day 2021. 2021 May;


Wang S., Flibotte S., Camunas-Soler J., MacDonald P.E., Johnson J.D.

Canadian Journal of Diabetes. 2021 April; 10.1016/j.jcjd.2021.03.007


Upregulation of cystolic reducing signaling through SENP1 is required for beta-cell functional compensation to short-term high fat diet

The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;


Modelling of Electrical Fingerprints Reveals Transcriptomic Profiles Linked to Alpha Cell Dysfunction in Type 2 Diabetes

The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;


Dai XQ, Camunas-Soler J, Briant LJB, dos Santos T, Spigelman AF, Walker EM, Arrojo e Drigo R, Bautista A, Jones RC, Lyon J, Nie A, Smith N, Manning Fox JE, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE

BioRxiv. 2021 April; 10.1101/2021.04.08.435504


Bevacqua R.J., Dai X., Lam J.Y., Gu X., Friedlander M.S.H., Tellez K., Miguel-Escalada I., Bonàs-Guarch S., Atla G., Zhao W., Kim S.H., Dominguez A.A., Qi L.S., Ferrer J., MacDonald P.E., Kim S.K.

Nature Communications. 2021 April; 12 (1) 10.1038/s41467-021-22651-w


Loss of the Diabetes Risk Gene ZMIZ1 Impairs Insulin Secretion and Beta-Cell Function

The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;


Müller J.A., Groß R., Conzelmann C., Krüger J., Merle U., Steinhart J., Weil T., Koepke L., Bozzo C.P., Read C., Fois G., Eiseler T., Gehrmann J., van Vuuren J., Wessbecher I.M., Frick M., Costa I.G., Breunig M., Grüner B., Peters L., Schuster M., Liebau S., Seufferlein T., Stenger S., Stenzinger A., MacDonald P.E., Kirchhoff F., Sparrer K.M.J., Walther P., Lickert H., Barth T.F.E., Wagner M., Münch J., Heller S., Kleger A.

Nature Metabolism. 2021 February; 3 (2):149-165 10.1038/s42255-021-00347-1


Nalbach L., Roma L.P., Schmitt B.M., Becker V., Körbel C., Wrublewsky S., Pack M., Später T., Metzger W., Menger M.M., Frueh F.S., Götz C., Lin H., EM Fox J., MacDonald P.E., Menger M.D., Laschke M.W., Ampofo E.

EMBO Molecular Medicine. 2021 January; 13 (1) 10.15252/emmm.202012616


dos Santos T., MacDonald P.E.

Islets. 2021 January; 13 (3-4):80-83 10.1080/19382014.2021.1914507


Armour S.L., Anderson S.J., Richardson S.J., Ding Y., Carey C., Lyon J., Maheshwari R.R., Al-Jahdami N., Krasnogor N., Morgan N.G., MacDonald P., Shaw J.A.M., White M.G.

ENDOCRINOLOGY. 2021 January; 161 (4):1-10 10.1210/ENDOCR/BQAA011


Glycine Receptor Signaling in Human Pancreatic Islets

ADI-HRD Symposium 2020. 2020 December;


Exploring Alpha Cell Heterogeneity Through Multi- Dimensional Approaches

ADI-HRD Symposium 2020. 2020 December;


Beta-Cell-Specific Ablation of SENP1 Worsens Oral Glucose Tolerance After Long-Term High Fat Diet

ADI Research Day 2020. 2020 November;


Exploring Alpha-Cell Heterogeneity Through Multi-Synthesis in Lipid Metabolism

ADI Research Day 2020. 2020 November;


Glycine Receptor Signaling in Human Pancreatic Islets

ADI Research Day 2020. 2020 November;


Expression of Distinct Transcriptomic Marker Genes Influence Electrophysiological Properties of Human Islet Cells

ADI Research Day 2020. 2020 November;


Nalbach L., Roma L.P., Schmitt B.M., Becker V., Körbel C., Wrublewsky S., Pack M., Später T., Metzger W., Menger M.M., Frueh F.S., Götz C., Lin H., EM Fox J., MacDonald P.E., Menger M.D., Laschke M.W., Ampofo E.

EMBO Molecular Medicine. 2020 November; 13 (1):e12616 10.15252/emmm.202012616


Molecular Mechanisms of Genetic Risk for Type 2 Diabetes: A Focus on ZMIZ1

ADI Research Day 2020. 2020 November;


Exploring Alpha Cell Heterogeneity Through Multi- Dimensional Approaches

Deutsches Zentrum für Diabetesforschung Diabetes Research School. 2020 October;


Expression of distinct transcriptomic marker genes influence electrophysiological properties of human islet cells

Human Islet Research Network 2020 Virtual Annual Investigator Meeting. 2020 October;