Patrick MacDonald

Area of Study / Keywords

diabetes metabolomics tissue bank genetics toxicology

---

About

Prof. Patrick MacDonald is currently appointed as Professor in the Department of Pharmacology in the Faculty of Medicine & Dentistry.

PMCOL 450 - Diabetes and Its Pharmacotherapy

This course will provide an overview of the current understanding of blood glucose homeostasis, insulin secretion and action, the actions of other important blood sugar-regulating hormones and the pathology of diabetes. Current pharmacological approaches for lowering blood glucose will be discussed, as will the latest experimental approaches in identifying potential drug targets and new treatments for diabetes. At the end of the course, students should have an appreciation for the mechanisms that control glucose homeostasis in health and diabetes, the diversity of drug targets and mechanisms by which diabetes drugs promote glucose control, and current rationale and lines of research leading to potential new treatments. Prerequisites: PMCOL 343 and 344 or consent of instructor.

---

PMCOL 550 - Introduction to the Pharmacology of Diabetes

This course is intended for graduate students and will provide an overview of the current understanding of blood glucose homeostasis, insulin secretion and action, the actions of other important blood sugar-regulating hormones and the pathology of diabetes. Current pharmacological approaches for lowering blood glucose will be discussed, as will the latest experimental approaches in identifying potential drug targets and new treatments for diabetes. At the end of the course, students should have an appreciation for the mechanisms that control glucose homeostasis in health and diabetes, the diversity of drug targets and mechanisms by which diabetes drugs promote glucose control, and current rationale and lines of research leading to potential new treatments. Prerequisites: PMCOL 343 and 344 or consent of Department.

---

Browse more courses taught by Patrick MacDonald

Skovsø S., Panzhinskiy E., Kolic J., Cen H.H., Dionne D.A., Dai X.Q., Sharma R.B., Elghazi L., Ellis C.E., Faulkner K., Marcil S.A.M., Overby P., Noursadeghi N., Hutchinson D., Hu X., Li H., Modi H., Wildi J.S., Botezelli J.D., Noh H.L., Suk S., Gablaski B., Bautista A., Kim R., Cras-Méneur C., Flibotte S., Sinha S., Luciani D.S., Nislow C., Rideout E.J., Cytrynbaum E.N., Kim J.K., Bernal-Mizrachi E., Alonso L.C., MacDonald P.E., Johnson J.D.

Nature Communications. 2022 December; 13 (1) 10.1038/s41467-022-28039-8

---

Sto�er A., �terk M., Paradi� Leitgeb E., Markovic R., Skelin Klemen M., Ellis C.E., Kri�ancic Bombek L., Dolen�ek J., MacDonald P.E., Gosak M.

Frontiers in Endocrinology. 2022 June; 13 10.3389/fendo.2022.922640

---

Dai X.Q., Camunas-Soler J., Briant L.J.B., dos Santos T., Spigelman A.F., Walker E.M., Arrojo e Drigo R., Bautista A., Jones R.C., Avrahami D., Lyon J., Nie A., Smith N., Zhang Y., Johnson J., Manning Fox J.E., Michelakis E.D., Light P.E., Kaestner K.H., Kim S.K., Rorsman P., Stein R.W., Quake S.R., MacDonald P.E.

Cell Metabolism. 2022 February; 34 (2):256-268.e5 10.1016/j.cmet.2021.12.021

---

Marcheva B., Weidemann B.J., Taguchi A., Perelis M., Ramsey K.M., Newman M.V., Kobayashi Y., Omura C., Fox J.E.M., Lin H., Macdonald P.E., Bass J.

eLife. 2022 February; 11 10.7554/ELIFE.75132

---

Marquez-Curtis L.A., Dai X.Q., Hang Y., Lam J.Y., Lyon J., Manning Fox J.E., McGann L.E., MacDonald P.E., Kim S.K., Elliott J.A.W.

PLoS One. 2022 January; 17 (1 January) 10.1371/journal.pone.0263005

---

Dafoe T.J., Dos Santos T., Spigelman A.F., Lyon J., Smith N., Bautista A., MacDonald P.E., Manning Fox J.E.

Islets. 2022 January; 14 (1):101-113 10.1080/19382014.2022.2047571

---

Wang S., Flibotte S., Camunas-Soler J., MacDonald P.E., Johnson J.D.

Canadian Journal of Diabetes. 2021 December; 45 (8):775-784.e2 10.1016/j.jcjd.2021.03.007

---

Bevacqua R.J., Dai X., Lam J.Y., Gu X., Friedlander M.S.H., Tellez K., Miguel-Escalada I., Bonàs-Guarch S., Atla G., Zhao W., Kim S.H., Dominguez A.A., Qi L.S., Ferrer J., MacDonald P.E., Kim S.K.

Nature Communications. 2021 December; 12 (1) 10.1038/s41467-021-22651-w

---

ADI Research Day 2020. 2021 November;

---

Kim A., Knudsen J.G., Madara J.C., Benrick A., Hill T., Kadir L.A., Kellard J.A., Mellander L., Miranda C., Lin H., James T., Suba K., Spigelman A.F., Wu Y., Macdonald P.E., Asterholm I.W., Magnussen T., Christensen M., Visboll T., Salem V., Knop F.K., Rorsman P., Lowell B.B., Briant L.J.B.

eLife. 2021 November; 10 10.7554/eLife.72919

---

Lin H., Smith N., Spigelman A.F., Suzuki K., Ferdaoussi M., Alghamdi T.A., Lewandowski S.L., Jin Y., Bautista A., Wang Y.W., Manning Fox J.E., Merrins M.J., Buteau J., MacDonald P.E.

DIABETES. 2021 November; 70 (11):2626-2638 10.2337/db20-1235

---

Shrestha S., Saunders D.C., Walker J.T., Camunas-Soler J., Dai X.Q., Haliyur R., Aramandla R., Poffenberger G., Prasad N., Bottino R., Stein R., Cartailler J.P., Parker S.C.J., MacDonald P.E., Levy S.E., Powers A.C., Brissova M.

JCI Insight. 2021 September; 6 (18) 10.1172/jci.insight.151621

---

Human Islet Research Network 2021 Virtual Annual Investigator Meeting. 2021 September;

---

Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SCJ, MacDonald PE, Levy SE, Powers AC, Brissova M

JCI Insight. 2021 August; 6 (18):e151621 10.1101/2021.02.23.432522

---

Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Jin Y, Bautista A, Wang YW, Manning Fox JE, Buteau J, MacDonald PE

DIABETES. 2021 August; 70 (9) 10.2337/db20-1235

---

Human Islet Research Network 2021 Virtual Annual Investigator Meeting. 2021 July;

---

CIRTN-R2FIC Journal Club. 2021 June;

---

Pharmacology Research Day 2021. 2021 May;

---

Pharmacology Research Day 2021. 2021 May;

---

Pharmacology Research Day 2021. 2021 May;

---

Wang S., Flibotte S., Camunas-Soler J., MacDonald P.E., Johnson J.D.

Canadian Journal of Diabetes. 2021 April; 10.1016/j.jcjd.2021.03.007

---

The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;

---

The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;

---

Dai XQ, Camunas-Soler J, Briant LJB, dos Santos T, Spigelman AF, Walker EM, Arrojo e Drigo R, Bautista A, Jones RC, Lyon J, Nie A, Smith N, Manning Fox JE, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE

BioRxiv. 2021 April; 10.1101/2021.04.08.435504

---

Bevacqua R.J., Dai X., Lam J.Y., Gu X., Friedlander M.S.H., Tellez K., Miguel-Escalada I., Bonàs-Guarch S., Atla G., Zhao W., Kim S.H., Dominguez A.A., Qi L.S., Ferrer J., MacDonald P.E., Kim S.K.

Nature Communications. 2021 April; 12 (1) 10.1038/s41467-021-22651-w

---

The 100th Anniversary of University of Toronto’s Discovery of Insulin: A Scientific Symposium Celebration. 2021 April;

---

Müller J.A., Groß R., Conzelmann C., Krüger J., Merle U., Steinhart J., Weil T., Koepke L., Bozzo C.P., Read C., Fois G., Eiseler T., Gehrmann J., van Vuuren J., Wessbecher I.M., Frick M., Costa I.G., Breunig M., Grüner B., Peters L., Schuster M., Liebau S., Seufferlein T., Stenger S., Stenzinger A., MacDonald P.E., Kirchhoff F., Sparrer K.M.J., Walther P., Lickert H., Barth T.F.E., Wagner M., Münch J., Heller S., Kleger A.

Nature Metabolism. 2021 February; 3 (2):149-165 10.1038/s42255-021-00347-1

---

Nalbach L., Roma L.P., Schmitt B.M., Becker V., Körbel C., Wrublewsky S., Pack M., Später T., Metzger W., Menger M.M., Frueh F.S., Götz C., Lin H., EM Fox J., MacDonald P.E., Menger M.D., Laschke M.W., Ampofo E.

EMBO Molecular Medicine. 2021 January; 13 (1) 10.15252/emmm.202012616

---

dos Santos T., MacDonald P.E.

Islets. 2021 January; 13 (3-4):80-83 10.1080/19382014.2021.1914507

---

Armour S.L., Anderson S.J., Richardson S.J., Ding Y., Carey C., Lyon J., Maheshwari R.R., Al-Jahdami N., Krasnogor N., Morgan N.G., MacDonald P., Shaw J.A.M., White M.G.

ENDOCRINOLOGY. 2021 January; 161 (4):1-10 10.1210/ENDOCR/BQAA011

---

ADI-HRD Symposium 2020. 2020 December;

---

ADI-HRD Symposium 2020. 2020 December;

---

ADI Research Day 2020. 2020 November;

---

ADI Research Day 2020. 2020 November;

---

ADI Research Day 2020. 2020 November;

---

ADI Research Day 2020. 2020 November;

---

Nalbach L., Roma L.P., Schmitt B.M., Becker V., Körbel C., Wrublewsky S., Pack M., Später T., Metzger W., Menger M.M., Frueh F.S., Götz C., Lin H., EM Fox J., MacDonald P.E., Menger M.D., Laschke M.W., Ampofo E.

EMBO Molecular Medicine. 2020 November; 13 (1):e12616 10.15252/emmm.202012616

---

ADI Research Day 2020. 2020 November;

---

Deutsches Zentrum für Diabetesforschung Diabetes Research School. 2020 October;

---

Human Islet Research Network 2020 Virtual Annual Investigator Meeting. 2020 October;