Ratmir Derda received his B.Sci. in Physics from Moscow Institute of Physics and Technology in 2001 and Ph.D. in Chemistry from the University of Wisconsin-Madison in 2008, under the supervision of Laura L. Kiessling. From 2008 to 2011, he was a postdoctoral researcher at Harvard University working under the supervision of George M. Whitesides and and Donald E. Ingber. He is currently Assistant Professor at the Department of Chemistry and Principal Investigator at the Alberta Glycomics Centre and SENTINEL Bioactive Paper Network. His recent awards include Young Investigator Award from Boulder Peptide Society (2014), University of Alberta Award for Outstanding Mentorship in Undergraduate Research & Creative Activities (2014) and Canadian Rising Star in Global Health award from Grand Challenges Canada (2011)
Research Vision: My lab works at the interface of chemistry and biology. Our general areas of interest are:
Genetically-encoded libraries of small molecules for ligand discovery is enabled by our ability to synthesize million to billion-scale libraries of small molecules from genetically-encoded peptide libraries. (1) We use these libraries for development of inhibitors for therapeutically-important proteins and non-druggable proteins, with specific emphasis on proteins that recognize complex carbohydrates. (2) Our lab uses genetically-encoded libraries to develop materials that control differentiation of cells (see iCID). (3) We are interested in fundamental principles that govern selection and evolution of molecular interaction in complex selection landscapes. This knowledge will help us design ligands and probes for targets in a complex setting (receptors on the surface of the whole cell, disease-associated proteins circulating in serum, etc)
Immobilized Chemical Inducers of Differentiation (iCID) and asymmetric cell division: In living organisms, it is often the location of the molecules, not their overall concentration, that determines the cell fate. My lab develops multiple approaches for controlling spatial gradients of biomolecules in cells and differentiation of cells during cell division (aka, asymmetric division). Specifically, we investigate the differentiation events that govern tumor development and control dynamic equilibrium between tumor-initiating cancer stem cells (CSC) and non-stem cancer cells (NSCC).
Diagnostics: The Derda group is interested in developing diagnostic platforms for the point-of-care detection of bacteria, antimicrobial susceptibility or drug-resistance of cells and detection of disease biomarkers in serum.
For our recent publications see http://derda.chem.ualberta.ca/publications/
The lab welcomes students ready to learn these skills:
The correlation of structure and chemical bonding in carbon compounds with the physical properties and chemical reactivity of organic molecules. Discussion will be based on functional groups with emphasis on hydrocarbons and derivatives that contain halogens, oxygen, sulfur, and the hydroxy group. Introduction to stereochemistry, three dimensional structure, reaction mechanisms, especially addition to double bonds, nucleophilic substitution and elimination reactions. Prerequisite CHEM 101 or 103. Note: Students who have obtained credit for CHEM 161 or 164 cannot take CHEM 261 for credit. Engineering students who take this course will receive *4.5.Winter Term 2022
A remote delivery offering that is a continuation of the structural and chemical properties of the basic functional groups of organic compounds including alkynes, aromatic compounds, aldehydes, ketones, carboxylic acids and their derivatives and amines. Illustration of these functional groups in natural products such as carbohydrates, amino acids and proteins, nucleic acids and lipids. Discussion of the application of spectroscopic methods for the structure determination in simple organic molecules. Seminars will emphasize the virtual application of laboratory techniques in standard organic reactions, as well as online workshops for NMR and structure determination. Prerequisites: CHEM 261 or 264. Note: Students who have obtained credit for CHEM 263 cannot take CHEM 265 for credit.Fall Term 2021