Rene Jacobs
Professor, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept
Contact
Professor, Faculty of Agricultural, Life and Environmental Sci - Ag, Food & Nutri Sci Dept
- rjacobs@ualberta.ca
- Phone
- (780) 492-2343
- Address
-
4-002E Li Ka Shing Centre For Research
11203 - 87 Ave NWEdmonton ABT6G 2H5
Overview
About
Degree
PhD, Biochemistry, Memorial University of Newfoundland
Research
Major Responsibilities/Research Interests
Dr. René Jacobs was trained in biochemistry and molecular biology at both the Memorial University of Newfoundland and the University of Alberta. In 2009, He was appointed to the Department of Agricultural, Food and Nutritional Science at the University of Alberta. Dr. Jacobs’ research program incorporates “state of the science” in vivo techniques, biochemical analysis and nutrigenomics as part of a comprehensive, multidisciplinary approach seeking to understand the complex interactions involved in the etiology of obesity, T2DM and other chronic diseases.
Courses
AFNS 602 - Graduate Reading Project
Individual study. Critical reviews of selected literature under the direction of a Faculty member. Note: May be taken more than once if the topic is different. Prerequisite: consent of Department.
NUTR 301 - Fundamentals of Nutritional Biochemistry and Metabolism I
Fundamentals of nutrition, emphasizing energy, carbohydrates, lipids and proteins. The lab will use common techniques to illustrate principles of human nutrition. Not to be taken if credit received for NUTR 303. Prerequisites: BIOCH 200 and PHYSL 210. Pre- or corequisite: BIOCH 310.
NUTR 302 - Fundamentals of Nutritional Biochemistry and Metabolism II
Fundamentals of nutrition with emphasis on vitamins and inorganic elements. The lab will use common techniques to illustrate principles of human nutrition. Not to be taken if credit received for NUTR 304. Prerequisites: BIOCH 310 and NUTR 301.
NUTR 303 - Fundamentals of Nutritional Biochemistry and Metabolism I
Fundamentals of nutrition with emphasis on vitamins and inorganic elements. Not to be taken if credit received for NUTR 301. Prerequisites: BIOCH 310 and PHYSL 210. NU FS 305 recommended.
NUTR 304 - Fundamentals of Nutritional Biochemistry and Metabolism II
Fundamentals of nutrition with emphasis on vitamins and inorganic elements. Not to be taken if credit received for NUTR 302. Prerequisites: BIOCH 310 and PHYSL 210. NUTR 303 or NU FS 305 recommended.
Publications
Choline Deficiency attenuates body weight gain and improves glucose tolerance in ob/ob mice
Author(s): Wu G, Zhang L, Li T, Lopaschuk G, Vance DE, Jacobs RL
Publication Date:
2012
Publication: Journal of Obesity
External Link: http://www.hindawi.com/journals/jobes/2012/319172/
ntimicrobial activity in the egg wax of the tick Amblyomma hebraeum (Acari: Ixodidae) is associated with free fatty acids C16:1 and C18:2
Author(s): Yu Z, Thomson ELS, Liu J, Dennis JJ, Jacobs RL, Kaufman WR
Publication Date:
2012
Publication: Exp Appl Acarol.
A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes
Author(s): Wiebe N, Padwal R, Field C, Marks S, Jacobs RL, Tonelli M
Publication Date:
2011
Publication: BMC Medicine
Volume: 123
Page Numbers: 1-18
Phospholipid Biosynthesis
Author(s): Kelly KB and Jacobs RL
Publication Date:
2011
Publication: AOCS Lipid Library
Methyl balance and transmethylation fluxes in humans
Author(s): Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C
Publication Date:
2007
Publication: Am J Clin Nutr.
Volume: 85
Issue: 1
Page Numbers: 19-25
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=17209172
Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated with Diet-Induced Obesity
Author(s): Koonen, DPY, Jacobs RL, Febbraio M, Young ME, Ong H, Vance DE, Dyck JRB
Publication Date:
2007
Publication: Diabetes
Volume: 56
Page Numbers: 2863 -2871
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=17728375
Hepatic phosphatidylethanolamine N-methyltransferase expression is increased in diabetic rats
Author(s): Hartz CS, Nieman KM, Jacobs RL, Vance DE, Schalinske KL
Publication Date:
2006
Publication: J Nutr. 2006;
Volume: 136(
Issue: 12):
Page Numbers: 3005-3009.
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=17116711%5Buid%5D
Is it time to re-evaluate methyl balance in humans?
Author(s): Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL*
Publication Date:
2006
Publication: Am J Clin Nutr.
Volume: 83
Issue: 1
Page Numbers: 5-10
External Link: http://www.ajcn.org/content/83/1/5.full
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice
Author(s): Jacobs RL, Stead LM, Devlin C, Tabas I, Brosnan ME, Brosnan JT, Vance DE
Publication Date:
2005
Publication: J Biol Chem.
Volume: 280
Issue: 31
Page Numbers: 28299-28305.
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=15958390
Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins
Author(s): Jacobs RL, Devlin C, Tabas I, Vance DE
Publication Date:
2004
Publication: J Biol Chem.
Volume: 279
Issue: 45
Page Numbers: 47402-47410
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=15331603
Methylation demand and homocysteine metabolism
Author(s): Stead LM, Jacobs RL, Brosnan ME, Brosnan JT
Publication Date:
2004
Publication: Adv Enzyme Regul.
Volume: 44
Page Numbers: 321-333
Methylation demand: a key determinant of homocysteine metabolism
Author(s): Brosnan JT, Jacobs RL, Stead LM, Brosnan ME
Publication Date:
2004
Publication: Acta Biochim Pol.
Volume: 51
Issue: 2
Page Numbers: 405-413
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=15218538
Hormonal Regulation of Cystathionine Beta-Synthase Expression
Author(s): Ratnam S, Maclean KN, Jacobs RL, Brosnan ME, Kraus JP and Brosnan JT
Publication Date:
2002
Publication: J Biol Chem.
Volume: 277
Issue: 45
Page Numbers: 42912-42918
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=12198128
Hyperhomocysteinemia in rats results in lowered plasma homocysteine and increased hepatic transsulfuration flux
Author(s): Jacobs RL, Stead LM, Brosnan ME, and Brosnan JT
Publication Date:
2001
Publication: J Biol Chem. 2001
Issue: 276
Page Numbers: 43740-43747
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=11595668%5Buid%5D
Methylation Demand and Homocysteine Metabolism: Effects of dietary provision and creatine and guanidinoacetate
Author(s): Stead LM, Au PT, Jacobs RL, Brosnan ME, and Brosnan JT
Publication Date:
2001
Publication: J. Physiol Endocrinol Metab. 2001
Issue: 281
Page Numbers: E1095-1100
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=11595668%5Buid%5D
Plasma homocysteine is decreased in the hypothyroid rat
Author(s): Jacobs RL, Stead LM, Brosnan ME, and Brosnan JT
Publication Date:
2000
Publication: Can. J. Physiol. Pharmacol
Issue: 78
Page Numbers: 1-6
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=10926163
Regulation of homocysteine metabolism
Author(s): House JD, Jacobs RL, Stead LM, Brosnan ME, and Brosnan JT
Publication Date:
1999
Publication: Advances in Enzyme Regulation.
Issue: 39
Page Numbers: 69-91
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=10470367
Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism
Author(s): Jacobs RL, House JD, Brosnan ME, and Brosnan JT
Publication Date:
1998
Publication: Diabetes
Issue: 47
Page Numbers: 1967-1970
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=9836532%5Buid%5D
A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans
Author(s): Amy K. Walker, Rene´ L. Jacobs, Jennifer L. Watts, Veerle Rottiers, Karen Jiang, Deirdre M. Finnegan,Toshi Shioda, Malene Hansen, Fajun Yang, Lorissa J. Niebergall, Dennis E. Vance, Monika Tzoneva, Anne C. Hart, and Anders M. Naar
Publication: Cell
Volume: 147
Page Numbers: 1-13
Tamoxifen induces triacylglycerol accumulation in mouse liver by activation of fatty acid synthesis. Hepatology
Author(s): Cole LK, Jacobs RL, Vance DE
Publication: Epub
Issue: 2010 Jun 16
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=20658461
Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-aged Mice to Diet-induced Insulin Resistance. Diabetes
Author(s): Koonen DP, Sung MM, Kao CK, Dolinsky VW, Koves TR, Ilkayeva O, Jacobs RL, Vance DE, Light PE, Muoio DM, Febbraio M, Dyck JR
Publication: Diabetes
Volume: 59
Issue: 6
Page Numbers: 1366-1375
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=20299464
amoxifen induces triacylglycerol accumulation in mouse liver by activation of fatty acid synthesis
Author(s): Cole LK, Jacobs RL, Vance DE
Publication: Hepatology
Phosphatidylethanolamine N-Methyltransferase – Unexpected Roles in Animal Biochemistry and Physiology
Author(s): Vance DE, Li Z, Jacobs RL
Publication: J Biol Chem.
Volume: 282
Page Numbers: 33237-33241
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=17881348%5Buid%5D
Control of one-carbon genes by SERBP-1 links SAMe production, phosphatidylcholine biosynthesis, and hepatic lipogenesis
Author(s): Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall L, Vance DE, Hart AC, Naar AM
Publication: CELL
Volume: 147
Page Numbers: 1-13
Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Feda High-Fat Diet
Author(s): Rafael Deminice,Robin P. da Silva, Simon G. Lamarre, Colin Brown, George N. Furey, Shannon A. McCarter, Alceu Afonso Jordao, Karen B. Kelly, Kirst King-Jones, Rene´ L. Jacobs, Margaret E. Brosnan,and John T. Brosnan
Publication: The Journal of Nutrition
Hepatic CTP:phosphocholine cytidylyltransferase-α is a critical predictor of plasma HDL and VLDL
Author(s): Jacobs RL, Lingrell S, Zhao Y, Francis GA, Vance DE
Publication: J Biol Chem.
Volume: 283
Page Numbers: 2147–2155
Lack of Phosphatidylethanolamine N-methyltransferase alters plasma VLDL and Attenuates Atherosclerosis in Mice Lacking LDL Receptors
Author(s): Zhao Y, Su B, Jacobs RL, Kennedy BP, Francis GA, Waddington E, Brosnan JT, Vance JE, and Vance DE
Publication: Arterioscler Thromb Vasc Biol.
Issue: 9
Page Numbers: 1349-1355
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=19520976%5Buid%5D
Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survivability after 70% partial hepatectomy in mice
Author(s): Ling NJ, Chaba T, Zhu LF, Jacobs RL
Publication: Hepatology
Volume: 55
Issue: 4
Page Numbers: 1094-1102
Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation
Author(s): Jacobs RL, Lingrell S, Dyck JR, Vance DE
Publication: J Biol Chem. 2007 Feb 16
Volume: 282
Issue: 7
Page Numbers: 4516-4523
External Link: http://www.ncbi.nlm.nih.gov/pubmed?term=17179149
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
Author(s): Zhao Y, Koonen DP, Sletten T, Su B, Lingrell S, Cao G, Peake DA, Kuo MS, Proctor SD, Kennedy BP, Dyck JR, Vance DE
Publication: J Biol Chem
Volume: 285
Issue: 29
Page Numbers: 22403-22413