PMCOL 406 - Molecular Mechanisms of Drug Action

3 units (fi 6)(EITHER, 3-0-0)

This course will present an overview of structure-based drug design, and delve into the molecular and structural factors that underlie drug affinity and efficacy. Concepts will be exemplified using receptor, ion channel, transporter, enzyme, and other protein families that represent important drug targets. Part of the course will be structured around the critical analysis of primary literature on related topics. Students will also have an opportunity to explore protein-drug interactions using molecular viewing software. Restricted to students enrolled in the Pharmacology Honors, Specialization, and Major BSc degree programs. Prerequisites: PMCOL 343, PMCOL 344, and PMCOL 306, BIOCH 320, or consent of Department.