ONCOL 520 - Tumor Biology

★ 3 (fi 6)(SECOND, 3-0-0)

The course will provide an introduction to the basic science of oncology. Topics to be covered comprise: the genetic basis of cancer, including the role of proto-oncogenes and tumor suppressor genes; mechanisms of carcinogenesis and radiation-sensitivity, including DNA repair and cell cycle control; the molecular basis of tumor metastasis, including tumor cell invasion, extravasation and dormancy; the role of inflammation in cancer initiation and progression; angiogenesis; cancer genetics, and epigenetics; cell signaling; experimental therapeutics; cancer stem cells; drug-resistance; metabolism and palliation. Course offered in alternate (even-numbered) years. Prerequisites: BIOCH 200, and one of the following: BIOCH 320 or 330 or ONCOL 320.

PAED 600 - Critical Discussions of Biomedical and Clinical Research

★ 3 (fi 6)(EITHER, 1-0-6)

This course follows a discovery learning format to critically evaluate scientific literature in a round table discussion. This course centers on principles of biomedical and clinical research as presented in the health sciences literature related to maternal and child health. Prerequisite or Corequisites: Restricted to graduate students in Paediatrics. Graduate students in other programs will require permission from the course coordinators/instructor.