This course will introduce the student to common and advanced methods in bioinformatics. In lectures and hands-on computer sessions, the student will solve realistic biological questions in the areas of sequence analysis, distant homology detection, phylogeny, correlation of sequence to structure, protein structure analysis, and genomics. While the student will obtain a thorough understanding of bioinformatics methods, the focus is on application of methods in the context of molecular biology research rather than on details of algorithms or computer programming. As a final assignment students will write a mini-proposal for a molecular biology research project that incorporates a series of bioinformatics studies to complement and guide the experimental work. May not be taken for credit if credit has already been obtained in IMIN 410. Prerequisites: departmental consent. Priority given to MMI graduate students.