Faculty of Pharmacy and Pharmaceutical Sciences
This course is an introduction into Physiologically Based Biopharmaceutic Modeling (PBBM) and physiologically based pharmacokinetic (PBPK) modeling, relevant to modern drug development and regulatory biowaivers. The core pharmaceutical scientific focus is on understanding basic and advanced physical chemical, biopharmaceutic and pharmacokinetic principles through physiological based modeling approaches. The graduate and undergraduate students will actively engage with contemporary modeling software, concurrently learning both the pharmaceutical foundations and practical operation of the software and how this can be used in further mechanistic drug development and for regulatory applications. An appreciation of in silico drug development is important for both in order to develop a thorough understanding of physicochemical and biopharmaceutical principles and advanced concepts such as: in vitro in vivo correlation, bio-relevant dissolution and disposition phenomena and special populations. Prerequisites: Undergraduate students: Pharm 302 and 315 (pharmaceutics 2 and pharmacokinetics). Graduate students: pharmacy degree (M.Sc., PharmD) or equivalent with exposure to pharmaceutics and pharmacokinetics as undergraduate students or with consent from the faculty.