The primary objective is to provide students with the background knowledge and methodological skills to be discriminating and informed users of health-related quality of life measures and interpreters of HRQL evidence. Topics include uses of HRQL measures, various systems for classifying HRQL measures, methodologies for the assessment of reliability, validity, responsiveness, and interpretability, and conceptualization of major approaches for the development of HRQL measures (including psychometric, clinical, and economics and decision analytic approaches). Examples of different types of measures and their application in a wide variety of clinical areas are included. Note: Credit may not be obtained for both PHS 685 and SPH 685.