BIOCH 465 - Methods in Molecular Biophysics

3 units (fi 6)(EITHER, 3-0-0)

Faculty of Medicine and Dentistry

Survey of biophysical methods used in the characterization and structural determination of biological macromolecules, from ensemble measurements to single-molecule detection. Topics include mass spectrometry, optical spectroscopy, light microscopy, X-ray and neutron diffraction, electron microscopy, molecular dynamics and nuclear magnetic resonance. Emphasis is on using techniques in evaluating structure-function relationships through the discussion of representative macromolecular systems. Prerequisites: BIOCH 320 with a minimum grade of B- or consent of the Department. This course is intended for students in Honors or Specialization in Biochemistry. Students in other programs may be admitted subject to availability and with the consent of the Department. This course cannot be taken for credit if credit has already been obtained in BIOCH 460.