BIOCH 676 - Methods in Molecular Biophysics for Analysis of Protein Kinetics, Dynamics, Interactions & Catalysis

★ 3 (fi 6)(EITHER, 3-0-0)

Faculty of Medicine and Dentistry

This course will explore the development and application of kinetic models for protein interactions, dynamics, and enzyme catalysis that include the principle of microscopic reversibility/detailed balance. Focus topics may include, but are not limited to: numerical methods for fitting and analyses of experimental kinetic data derived from spectroscopic techniques, as well as blending of all-atom and coarse-grained molecular dynamics methods with experimental data to develop detailed molecular insights into proteins of biological interest. Prerequisites: BIOCH 420, 465, or equivalent and consent of the instructor. Maximum enrolment of 10 students. Offered in alternate years.