CHEM 454 - Bioconjugate Chemistry

3 units (fi 6)(EITHER, 3-0-0)

Faculty of Science

Discussion of organic reactions to modify or label biopolymers including proteins, carbohydrates, and nucleic acids. Topics will include mechanistic and methodological details of commonly employed reactions used for chemoselective labeling or modification of biomolecules to produce synthetic vaccines, antibody-drug conjugates, and native chemical ligation will be discussed. Prerequisites: CHEM 351 or BIOCH 200; CHEM 361. Note: This course may not be taken for credit if credit has already been received in CHEM 464.