Graduate-level discussion of organic reactions to modify or label biopolymers including proteins, carbohydrates, and nucleic acids. Topics will include mechanistic and methodological details of commonly employed reactions used for chemoselective labeling or modification of biomolecules to produce synthetic bioconjugates. Applications including synthetic vaccines, antibody-drug conjugates, and native chemical ligation will be discussed. Prerequisite: 1 year of introductory organic chemistry and 1 term of biochemistry, or consent of instructor. Not open to students with credit in CHEM 464 or 564.