Introduction to the principles of biophysical instrumentation. Various sensors are examined including strain gauges, inductive, capacitive, thermal, and piezoelectric sensors. Methods of measuring blood pressure are discussed. Origin of biopotentials; membrane and action potentials. Measurement of bioelectrical signals such as the ECG and EMG. Electrical safety, noise, impedance matching, and analog-to-digital conversion. Applications of electrodes, biochemical sensors, and lasers. Prerequisite: ECE 203 or E E 250 or consent of the Instructor. Credit may be obtained in only one of ECE 405 or EE BE 512.