This course is intended to provide a firm understanding of the physical and theoretical basis of biomedical optics. Both theoretic aspects of light propagation in tissue as well as practical imaging and sensing systems will be discussed. Single and multiple scattering of light is modeled, and light-transport and diffusion equations are developed. Imaging and sensing platforms including various microscopy technologies, optical-coherence tomography systems, and diffuse-imaging methods are analyzed in detail. Selected topics may include photoacoustic imaging, optical dyes and nanoparticle agents, novel emerging microscopy and deep-tissue imaging technologies, and applications to biological and clinical problems. Prerequisite: consent of Instructor.