This course will provide an overview of molecular imaging probes and their application in basic and clinical science. The course will have an emphasis on radionuclide based probes and on their application in oncology but will also introduce other classes of probes (optical, MR, x-ray contrast, ultrasound and photoacoustic) and other pathologies. The course will examine imaging techniques, cell and tissue targets for imaging probes, the chemical elaboration of molecular imaging probes and some applications in the diagnosis and treatment of human disease. Molecular imaging in drug development will also be addressed. Prerequisite: Consent of the Department.