Advanced principles of regulatory mechanisms in human and mammalian physiology, with in depth analysis of interrelationships between different organ systems in the maintenance of homeostasis. Clinical and physiologic perspectives are highlighted in the demonstration of how organ systems interact in health and the disruption in homeostasis which occurs in disease. Contemporary topics in energy and cardiovascular homeostasis such as the physiological adaptations to pregnancy, exercise, obesity and diabetes will be explored using an integrative, systems physiology approach. Suitable as preparation for careers in medicine, biomedical research and health-related fields. Prerequisites: consent of the Department. Priority given to students registered in a graduate program. Note: this course is not open to students with credit in the corresponding PHYSL 400 level course.