This course takes an in-depth look at the relationship between substance use and health, examining it through multiple lenses - neurobiological, medical, sociocultural, epidemiological, and political economy. We'll dissect how substances interact with the body and brain, explore the biological underpinnings of dependence, and analyze sociocultural, political, and economic factors that influence substance use patterns and health outcomes. You'll critically evaluate various prevention, treatment, and harm reduction strategies and policy debates, gaining a comprehensive understanding of this complex public health challenge across individual and population levels. Get ready to connect the dots between molecules and movements, biology and behaviour, and individual experiences and societal impact.