The organization and expression at the molecular level of information encoded in the nucleic acids of eukaryotic cells. The focus will be on genome structure and the regulation of gene expression at the levels of transcription, post-transcriptional processing, translation, post-translational modification and protein sorting. Recombinant DNA technologies and genetic engineering will be discussed as methods for studying the cellular processing of genetic information. Prerequisites: BIOCH 320 and 330, both with a minimum grade of B- or consent of Department. This course is intended for students in Honors or Specialization in Biochemistry. Students in other programs may be admitted subject to availability and with the consent of the Department. Graduate students may not register for credit (see BIOCH 530).
The organization and expression at the molecular level of information encoded in the nucleic acids of eukaryotic cells. The focus will be on genome structure and the regulation of gene expression at the levels of transcription, post-transcriptional processing, translation, post-translational modification and protein sorting. Recombinant DNA technologies and genetic engineering will be discussed as methods for studying the cellular processing of genetic information. Prerequisites: BIOCH 320 and 330, or BIOCH 203 and 205, all with a minimum grade of B- or consent of Department. Lectures are the same as for BIOCH 430, but with additional assignments and evaluation appropriate to graduate studies. This course may not be taken for credit if credit has already been obtained in BIOCH 430.
Seminar course for advanced students. Detailed consideration is given to recent advances in research on protein structure and function and mechanism of enzyme action. Prerequisite: BIOCH 420 or consent of Department.
Seminar course for advanced students. Detailed consideration is given to recent advances in research on protein structure and function and mechanism of enzyme action. Prerequisite: BIOCH 420 or consent of Department.
This course is designed to provide students with a comprehensive introduction to the biochemistry of nucleic acids. It covers: the structure and properties of nucleotides and nucleic acids; DNA-based information technologies; genes and chromosome structure; molecular mechanisms in DNA replication, repair, and recombination; RNA metabolism; protein synthesis and targeting; the regulation of gene expression. Prerequisites: BIOCH 200, CHEM 102 (or SCI 100), and CHEM 263, with a minimum GPA of 2.70 for these three courses. In the case of over-subscription, preference will be given to students enrolled in programs with a requirement for this course.