BIOCH 465 - Methods in Molecular Biophysics

★ 3 (fi 6)(EITHER, 3-0-0)

Survey of biophysical methods used in the characterization and structural determination of biological macromolecules, from ensemble measurements to single-molecule detection. Topics include mass spectrometry, optical spectroscopy, light microscopy, X-ray and neutron diffraction, electron microscopy, molecular dynamics and nuclear magnetic resonance. Emphasis is on using techniques in evaluating structure-function relationships through the discussion of representative macromolecular systems. Prerequisites: BIOCH 320 with a minimum grade of B- or consent of the Department. This course is intended for students in Honors or Specialization in Biochemistry. Students in other programs may be admitted subject to availability and with the consent of the Department. This course cannot be taken for credit if credit has already been obtained in BIOCH 460.

BIOCH 565 - Methods in Molecular Biophysics

★ 3 (fi 6)(EITHER, 3-0-0)

Survey of biophysical methods used in the characterization and structural determination of biological macromolecules, from ensemble measurements to single-molecule detection. Topics include mass spectrometry, optical spectroscopy, light microscopy, X-ray and neutron diffraction, electron microscopy, molecular dynamics and nuclear magnetic resonance. Emphasis is on using techniques in evaluating structure-function relationships through the discussion of representative macromolecular systems. Lectures are the same as for BIOCH 465, but with additional assignments and evaluation appropriate to graduate studies. This course cannot be taken for credit if credit has already been obtained in BIOCH 460 or 465.

BIOCH 609 - Macromolecular Structure Analysis

★ 3 (fi 6)(SECOND, 3-0-0)

Principles of X-ray crystallography as applied to the study of protein and nucleic acid structure. Practical aspects of diffraction and structure solution are demonstrated by a collaborative study of a suitable small molecule of biological interest. Designed for graduate students. Prerequisite: consent of Instructor. Maximum enrolment of 10 students. Offered in alternate years.

BIOCH 620 - Selected Topics in Protein Structure, Function, and Regulation

★ 3 (fi 6)(SECOND, 0-3S-0)

Directed reading and seminar course, based on papers taken from recent literature of protein research. Students critically discuss the papers and give oral presentations to the class. Designed for graduate students. Prerequisite: BIOCH 420 or equivalent, or consent of Department.

BIOCH 465 - Methods in Molecular Biophysics

★ 3 (fi 6)(EITHER, 3-0-0)

Survey of biophysical methods used in the characterization and structural determination of biological macromolecules, from ensemble measurements to single-molecule detection. Topics include mass spectrometry, optical spectroscopy, light microscopy, X-ray and neutron diffraction, electron microscopy, molecular dynamics and nuclear magnetic resonance. Emphasis is on using techniques in evaluating structure-function relationships through the discussion of representative macromolecular systems. Prerequisites: BIOCH 320 with a minimum grade of B- or consent of the Department. This course is intended for students in Honors or Specialization in Biochemistry. Students in other programs may be admitted subject to availability and with the consent of the Department. This course cannot be taken for credit if credit has already been obtained in BIOCH 460.

BIOCH 565 - Methods in Molecular Biophysics

★ 3 (fi 6)(EITHER, 3-0-0)

Survey of biophysical methods used in the characterization and structural determination of biological macromolecules, from ensemble measurements to single-molecule detection. Topics include mass spectrometry, optical spectroscopy, light microscopy, X-ray and neutron diffraction, electron microscopy, molecular dynamics and nuclear magnetic resonance. Emphasis is on using techniques in evaluating structure-function relationships through the discussion of representative macromolecular systems. Lectures are the same as for BIOCH 465, but with additional assignments and evaluation appropriate to graduate studies. This course cannot be taken for credit if credit has already been obtained in BIOCH 460 or 465.