A survey of human genetic variation and mutation in a molecular genetics context. Molecular basis of diseases and applications to genetic counseling and screening, chromosomal abnormalities, genomic imprinting, cancer genetics, gene mapping, population genetics, multifactorial inheritance, gene therapy, and ethical issues. Scheduled classes are the same as GENET 418, but with additional assignments and evaluation appropriate to graduate studies. Prerequisite: consent of instructor. Credit cannot be obtained for both GENET 418 and 518.