PMCOL 575 - Signal Transduction Systems as Pharmacological Targets

3 units (fi 6)(EITHER, 3-0-0)

Faculty of Medicine and Dentistry

Regulation of various aspects of cell regulation, including proliferation, differentiation, metabolism, survival, motility, and gene transcription, occur mainly via protein phosphorylation in a complex array of well-organized signal transduction pathways. This course will cover topics related to the pharmacological investigation of cellular transduction systems, the discovery of small molecules that alter cell signaling, and how pharmacological manipulation of these signaling pathways may be useful in the drug treatment of a diverse range of diseases, including metastatic, cardiovascular, inflammatory, immune, metabolic and neurodegenerative diseases. Prerequisites: Consent of Department.