CHEM 299 - Research Opportunity Program in Chemistry

★ 1.5 (fi 3)(EITHER, 0-0-3)

A credit/no-credit course for supervised participation in a faculty research project. Normally taken after completion of a minimum of *30 but not more than *60 in a program in the Faculty of Science. Prerequisite: GPA of 2.5 or higher, CHEM 101 or 161; and consent of Department. Specific projects may require additional prerequisites. Project and course information available on Department of Chemistry website. Prospective enrollees in CHEM 299 must apply to Department of Chemistry. Application does not guarantee an ROP position. Credit for this course may be obtained twice.

CHEM 399 - Research Experience in Chemistry

★ 1.5 (fi 3)(EITHER, 0-0-6)

A credit/no-credit course for participation in a research project under the direction of a member of the Department. Students taking CHEM 401 or 403 cannot concurrently take CHEM 399. Credits for CHEM 399 count as science options in all chemistry programs. Credit for this course may be obtained up to four times. Prerequisites: Departmental permission. *9 of 200-level chemistry or *3 of 300-level chemistry.

CHEM 454 - Bioconjugate Chemistry

★ 3 (fi 6)(EITHER, 3-0-0)

Discussion of organic reactions to modify or label biopolymers including proteins, carbohydrates, and nucleic acids. Topics will include mechanistic and methodological details of commonly employed reactions used for chemoselective labeling or modification of biomolecules to produce synthetic vaccines, antibody-drug conjugates, and native chemical ligation will be discussed. Prerequisites: CHEM 351 or BIOCH 200; CHEM 361. Note: This course may not be taken for credit if credit has already been received in CHEM 464.

CHEM 554 - Bioconjugate Chemistry

★ 3 (fi 6)(EITHER, 3-0-0)

Graduate-level discussion of organic reactions to modify or label biopolymers including proteins, carbohydrates, and nucleic acids. Topics will include mechanistic and methodological details of commonly employed reactions used for chemoselective labeling or modification of biomolecules to produce synthetic bioconjugates. Applications including synthetic vaccines, antibody-drug conjugates, and native chemical ligation will be discussed. Prerequisite: 1 year of introductory organic chemistry and 1 term of biochemistry, or consent of instructor. Not open to students with credit in CHEM 464 or 564.