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Kinetics of chemical reactions and design of ideal chemical reactors. Prerequisites: CME 265, CH E 343 and 374. Credit may not be obtained in this course if previous credit has been obtained for CH E 434.

Technical report writing; thermodynamics, material, and energy balances, and calibration experiments. Prerequisites: ENGL 199 or equivalent, CME 265 and CH E 243. Corequisite: CH E 312.

Statistical analysis of process data from chemical process plants and course laboratory experiments. Topics covered include linear and nonlinear regression, dimensionality reduction, classification, deep learning, and design of experiments. Prerequisites: CH E 351 and STAT 235. Corequisites: CH E 314 and CH E 345.

Statistical analysis of process data from chemical process plants and course laboratory experiments. Topics covered include linear and nonlinear regression, dimensionality reduction, classification, deep learning, and design of experiments. Prerequisites: CH E 351 and STAT 235. Corequisites: CH E 314 and CH E 345.

Statistical analysis of process data from chemical process plants and course laboratory experiments. Topics covered include linear and nonlinear regression, dimensionality reduction, classification, deep learning, and design of experiments. Prerequisites: CH E 351 and STAT 235. Corequisites: CH E 314 and CH E 345.

Formulation and solution of chemical and materials engineering problems; solution of systems of linear and nonlinear algebraic equations; numerical interpolation, differentiation and integration; numerical solution of ordinary and partial differential equations. Prerequisites: ENCMP 100 (or equivalent). MATH 102, 201 and 209.

Unit operations studied in this course include: settlers, thickeners, centrifuges, slurry pipelines and flotation columns. Course topics will also include: one dimensional homogeneous and multiphase flows, sedimentation and fluidization of multi-species systems, and drift flux theory. Prerequisite: CH E 312.

Design of separation processes with emphasis on the equilibrium stage concept, distillation, absorption and extraction. Prerequisites: CH E 343, 314. Corequisite: CH E 318. Credit may not be obtained in this course if previous credit has been obtained for CH E 316.

Integration of chemical engineering practice, theory and economics into capital project proposal, sustainable design and evaluation. Course work requires team and project work. Prerequisites: CH E 445, 446, 464, and ENGG 404. Registration restricted to students in the Oil Sands Elective.

Analysis and design of non-ideal chemical reactors for industrial product synthesis. Prerequisites: CH E 314, 318 and 345.

Introduction to process modeling and transient response analysis; design and analysis of feedback systems; stability analysis; process control applications; process control using digital computers. Prerequisites: CME 265, MATH 201 and 209. Corequisite: CH E 312.

Introduction to systems modeling and transient response analysis with an emphasis on mechanical engineering applications; design and analysis of feedback systems; stability analysis; feedforward control; process control applications. Prerequisites: MATH 201 or equivalent, MATH 209, and MEC E 330 or MEC E 331. Corequisite: MEC E 370 or MEC E 371. Restricted to students registered in the Mechanical Engineering program. Credit may not be obtained in this course if previous credit has been obtained for CH E 446.

Experiments in kinetics and mass transfer. Prerequisites: CH E 318, 345, 358, and 416.

Engineering design concepts; cost estimation; project planning and scheduling; plant safety and hazards analysis; selected project design examples. Prerequisites: CH E 314, 345, 316 or 416, and ENG M 310 or 401. Corequisite: ENGG 404. Credit may not be obtained in this course if previous credit has been obtained for CH E 365.

Integration of chemical engineering practice, theory and economics into capital project proposal, sustainable design and evaluation. Course work requires team and project work. Prerequisites: CH E 446, 464, and ENGG 404.

Mechanistic and empirical modelling of process dynamics; continuous- and discrete-time models; model fitting and regression analysis. Corequisites: CH E 314, 318 and 345. Credit cannot be obtained in this course if previous credit has been obtained for CH E 572.

Engineering analysis of processes such as cell growth and fermentation, purification of products, waste management, and bioremediation. Prerequisites: CME 265 and BIOL 107.

Introduction to principles of operation of fuel cells and their applications; historical and environmental perspectives; elementary electrochemistry, types of fuel cell - fuels, membranes and liquid ion conductors, operating conditions; factors affecting performance; applications as standing engines and mobile power sources. Limited to 3rd/4th year undergraduate students in engineering. Prerequisites: CH E 343, MAT E 202 or equivalent and MATH 201 or consent of Instructor.

Treatment of selected chemical engineering special topics of current interest to staff and students.

Introduction to the physical, chemical and engineering principles required for the design and operation of plants used for the upgrading of heavy oils and bitumens. Prerequisite: CH E 345.

Application of fluid mechanics, interfacial phenomena and colloid science to bitumen extraction. Prerequisites: CH E 312 and 314.

Introduction to energy conversion technologies, impact of energy sources on the planet/environment, energy analysis, heat integration and energy efficiency, conventional and non-conventional renewable energy conversion technologies, CO2 mitigation technologies, conversion of renewable carbon resources to produce bulk and fine chemicals. Life cycle and return on investment analysis for analyzing the effectiveness of different energy and chemical systems, sustainability metrics. Prerequisite: CH E 343, CH E 314

Principles of electrochemistry including physical chemistry of electrolyte solutions, ion transport in solution, ionic conductivity, electrode equilibrium, reference electrodes, electrode kinetics, heat effects in electrochemical cells, electrochemical energy conversion, fuel cells, batteries, supercapacitors, and electrocatalytic systems, electrolytic production of hydrogen.

Introduction to legislative regulations and hierarchy of integrated solid waste management, policy instruments on waste management, Waste handling and quantification, waste-disposal methods, circular economy in relation to waste management, characterization of solid waste, pretreatment of solid waste, thermochemical conversion of solid waste to energy, case studies on resource recovery from solid waste.

First and second generation biomass, bioenergy production technologies, biofuels, transformation of lignocellulosic biomass, biochemical conversion routes, selective catalytic conversion routes and high temperature thermochemical conversion, including pyrolysis and gasification, reaction chemistry of model cellulosic and lignin compounds. Computer-based process simulations for thermochemical transformation, reactor design problems related to biomass transformation.

Time and frequency domain representation of signals; Fourier Transform; spectral analysis of data; analysis of multivariate data; treatment of outliers and missing values in industrial data; filter design. Prerequisites: CH E 358 and 446.

Modeling and solving optimization problems in process systems engineering (PSE) applications. Topics covered include solving systems of nonlinear equations, optimality conditions, linear programming, unconstrained/constrained nonlinear programming, mixed integer programming, optimization modeling tools, and selected PSE applications. Prerequisites: MATH 102, 209, and CME 265. Corequisites: CH E 314, 318 and 345.

Digital and multivariable process control techniques; discrete-time analysis of dynamic systems; digital feedback control; Kalman filter and linear quadratic optimal control; model predictive control. Prerequisite: CH E 446 or equivalent.

Analysis and design of bioreactors. Characterization, Mechanisms and models of biocatalysis by cultures, whole cells and enzymes. Design and modification of biocatalytic systems. Introduction to the concepts of metabolic and enzyme engineering. Lab or simulated lab component. Prerequisites: CME 265 and BIOL 107

Survey of materials intended for biological applications; biomaterials-related biological phenomena (protein adsorption, blood coagulation and cell adhesion); biomaterials for engineering of blood vessel, bone and skin tissues. Two fundamental engineering philosophies will be stressed: structure-function relationship and purposeful manipulation for a desired outcome. Prerequisite: BIOL 107 or BME 210 or CH E 484 or consent of Instructor.

Exploration of how design principles are implemented in biotechnology and bioengineering. Topics cover all scales of bioengineering from processes to cells and biomolecules, and include how tools and innovative approaches, such as bioinformatics, artificial intelligence, influence the field.

Solutions of the transport equations of momentum, mass and energy. Transport processes are reviewed but emphasis is placed on the numerical solution of the governing differential equations. Different solution methodologies and software are presented.

Transport expressions for physical properties are combined with conservation laws to yield generalized equations used to solve a variety of engineering problems in fluid mechanics, and heat and mass transfer; steady-state and transient cases; special topics in non-Newtonian flow and forced diffusion.

Fundamental physical laws governing the behaviour of fluidparticle systems. Particle agglomeration and non-Newtonian pipeline flows; flow through porous media; particle settling; multiparticle drag relationships; particle interactions in dense, coarse particle slurry flows; flowing granular solids. Application of the physical laws in paste or thickened tailings pipelining; horizontal oil well production; oil sand hydrotransport; and bulk solids handling.

Emphasis is on the basics of colloid and interfacial phenomena. Aimed at upper level and graduate students in chemical and mineral engineering, chemistry and geochemistry with an interest in application to the energy sector, mineral processing, materials handling, and chemical industry.

Design and operation of mixing equipment in the process industries. Process results ranging from blending, solids suspension, and gas dispersion to reactor design and heat transfer will be covered. Laminar and turbulent regimes, stirred tanks and static mixers, and other specialized applications will be discussed. The course integrates fundamental chemical engineering concepts with equipment design, mixing theory, and turbulence theory. Credit cannot be obtained in this course if credit was previously obtained in CH E 420 or CH E 520.

Principles of thermodynamics; properties of homogeneous fluid phases; phase and chemical equilibria; application to industrial problems.

Advanced topics in macroscopic thermodynamics and fundamentals of statistical thermodynamics. Thermodynamics of composite systems including surface thermodynamics and thermodynamics in fields. Introduction to quantum mechanics. Principles of statistical thermodynamics. Construction of partition functions and calculations of basic thermodynamic properties for several fundamental systems. Applications will include properties of ideal gases, ideal solids and adsorbed gases.

Design of homogeneous and heterogeneous reactors for isothermal and non-isothermal operation; analysis of rate data; transport processes in heterogeneous catalytic systems.

Principles of heterogeneous catalysis and reactor analysis with emphasis on industrial catalytic reactions; characterization of heterogeneous catalysts.

Intended for graduate students who are familiar with basic biomaterials science. Focuses on: molecular design of biomaterial and biomaterial surfaces in order to modulate specific biological events; techniques to modulate biomaterial properties; assessment techniques for modifications. The biological events will be studied at the cellular and molecular level.

Selected topics related to empirical modelling of process systems are undertaken. Emphasis on time-series based modelling theory and techniques, (e.g., nonparametric, parametric, spectrum analysis, nonlinear, and closed-loop identification methods), model validation, experimental design, and applications in forecasting, analysis, and control.

Intended for graduate students who are familiar with basic modern control theory. Solution methods for dynamical systems, stability theory, classical optimal control methods, model predictive control and its computational tools.

Fundamentals and engineering applications of soft matter and interface science and technology.

Numerical solutions of engineering problems using linear and nonlinear sets of equations, ordinary and partial differential equations.

Polymerization, molar mass distributions, polymer analytical techniques, solution and blend thermodynamics, physical and chemical properties of polymers, lattice models, rubber thermodynamics, polymer processing, fluid flow and heat transfer in melt processing, special polymer project. Prerequisite: consent of Instructor. Not open to students with credit in MAT E 467 or CH E 539.

An advanced treatment of selected chemical engineering topics of current interest to staff and students.

Advanced treatment of selected topics in process dynamics and/or computer process control of current interest to staff and students.

Atoms and molecules, states of matter, chemistry of the elements. Prerequisite: Chemistry 30, or equivalent.

Rates of reactions, thermodynamics and equilibrium, electro-chemistry, modern applications of chemistry. Prerequisite: CHEM 101 or 103.

Atoms and molecules, states of matter, chemistry of the elements. Prerequisite: Chemistry 30, or equivalent. Note: Restricted to Engineering students only. Other students who take this course will receive 3 units.

Rates of reactions, thermodynamics and equilibrium, electrochemistry, modern applications of chemistry. Prerequisite: CHEM 103 or 101. Note: Restricted to Engineering students only. Other students who take this course will receive 3 units.

Principles, methods, and experimental applications emphasizing solution phase equilibria, titrimetry, volumetric laboratory skills, evaluation of experimental data, and applications of electrochemistry to analytical measurements. Includes examples of organic and inorganic analyses. Prerequisite: CHEM 102.

A continuation of CHEM 211 emphasizing the principles, methods, and experimental applications of separation techniques, atomic and molecular optical spectrometry, mass spectrometry, and evaluation of experimental data. Includes examples of organic and inorganic analyses and use of the analytical literature. Prerequisite: CHEM 211. Students who have previously taken CHEM 313 may not take CHEM 213 for credit.

The chemistry of main-group elements including a survey of the structure, bonding, and reactivity of their compounds. Transition-metal chemistry will be introduced. The course will include applications in industrial, biochemical, environmental, and materials science. Prerequisites: CHEM 102 or 105 and CHEM 261.

The correlation of structure and chemical bonding in carbon compounds with the physical properties and chemical reactivity of organic molecules. Discussion will be based on functional groups with emphasis on hydrocarbons and derivatives that contain halogens, oxygen, sulfur, and the hydroxy group. Introduction to stereochemistry, three dimensional structure, reaction mechanisms, especially addition to double bonds, nucleophilic substitution and elimination reactions. Prerequisite CHEM 101 or 103. Note: Students who have obtained credit for CHEM 264 cannot take CHEM 261 for credit. Engineering students who take this course will receive 4.5 units.

Continuation of the structural and chemical properties of the basic functional groups of organic compounds including alkynes, aromatic compounds, aldehydes, ketones, carboxylic acids and their derivatives and amines. Illustration of these functional groups in natural products such as carbohydrates, amino acids and proteins, nucleic acids and lipids. Discussion of the application of spectroscopic methods for the structure determination in simple organic molecules. Prerequisites: CHEM 261 or CHEM 264 and 266 or SCI 100. Students who have obtained credit for CHEM 265 cannot take CHEM 263 for credit.

A remote delivery offering that emphasizes the correlation of structure and chemical bonding in carbon compounds with the physical properties and chemical reactivity of organic molecules. Discussion will be based on functional groups with emphasis on hydrocarbons and derivatives that contain halogens, oxygen, sulfur, and the hydroxy group. Introduction to stereochemistry, three-dimensional structure, reaction mechanisms, especially addition to double bonds, nucleophilic substitution and elimination reactions. Seminars will emphasize virtual laboratory techniques and online workshops for IR spectroscopy and stereochemistry. Prerequisite CHEM 101 or 103. Note: Students who have obtained credit for CHEM 261 cannot take CHEM 264 for credit.

A remote delivery offering that is a continuation of the structural and chemical properties of the basic functional groups of organic compounds including alkynes, aromatic compounds, aldehydes, ketones, carboxylic acids and their derivatives and amines. Illustration of these functional groups in natural products such as carbohydrates, amino acids and proteins, nucleic acids and lipids. Discussion of the application of spectroscopic methods for the structure determination in simple organic molecules. Seminars will emphasize the virtual application of laboratory techniques in standard organic reactions, as well as online workshops for NMR and structure determination. Prerequisites: CHEM 261 or 264. Note: Students who have obtained credit for CHEM 263 cannot take CHEM 265 for credit.

A credit/no-credit course designed to complement lecture material covered in CHEM 264. This course will emphasize important laboratory skills for the purification and characterization of organic compounds. Prerequisite CHEM 101 or 103. Prerequisite or co-requisite: CHEM 264. Notes: (i) CHEM 266 is a requirement for higher level chemistry courses. (ii) Students who have obtained credit for CHEM 261 cannot take CHEM 266 for credit except by department recommendation.

A credit/no-credit course designed to complement lecture material covered in CHEM 265. This course will emphasize synthetic chemistry and practical applications of the laboratory skills learned in CHEM 266, as well as introduce spectroscopic analysis and structure determination. Prerequisite CHEM 261 or 266. Prerequisite or co- requisite: CHEM265. Notes: (i) CHEM 267 is a requirement for higher level chemistry courses. (ii) Students who have obtained credit for CHEM 263 cannot take CHEM 267 for credit except by department recommendation.

An introduction to the quantum view of nature with applications to atomic and molecular structure. Methods to describe the quantum world are introduced, used to describe the electronic structure of simple model systems, and applied to the hydrogen atom, many-electron atoms, simple diatomic molecules, and polyatomic molecules. The laboratory portion of the course consists of applications enriching and illustrating the lecture material, and incorporates the use of computers in predicting experimental results. Prerequisites: CHEM 102 or 105; one 200-level CHEM course; MATH 115 or 136 or 146 or 156; MATH 125; PHYS 124 or 144.

A credit/no-credit course for supervised participation in a faculty research project. Normally taken after completion of a minimum of 30 units but not more than 60 units in a program in the Faculty of Science. Prerequisite: GPA of 2.5 or higher, CHEM 101 or 161; and consent of Department. Specific projects may require additional prerequisites. Project and course information available on Department of Chemistry website. Prospective enrollees in CHEM 299 must apply to Department of Chemistry. Application does not guarantee an ROP position. Credit for this course may be obtained twice.

A credit/no-credit course that introduces students to the practices, environment, concepts, and other issues associated with the industrial workplace. Course includes lectures by professionals from the local chemical industry, industrial tours, and professional skills development such as resume writing and interviewing. Normally taken after completion of a minimum of 60 but not more than 90 units of course weight in a program in the Department of Chemistry. The course is offered for students in Chemistry Honors, Specialization, and Major Programs. Other students, contact the department for consent. Prerequisite: Satisfactory Standing and consent of Department.

The chemistry of environmental processes. Atmospheric chemistry; thermal and photochemical reactions of atmospheric gases including oxygen, ozone, hydroxy radical, and oxides of nitrogen and sulfur. Aquatic chemistry; characterization, reactions, and equilibria of dissolved species, water purification treatments. Metals and organohalides in the environment. Risk assessment. Prerequisites: CHEM 102; CHEM 261 or 264; CHEM 263 or 265; and one 200-level CHEM course or CH E 243.

The lecture and laboratory portions of this course will highlight sorption and phase partitioning; hydrolysis reactions; convective/diffusive transport; properties and behaviour of particles, including sedimentation, coagulation, and light scattering; and the significance of particulate matter in the atmosphere. Quantitative calculations will be emphasized. The lecture component will provide theoretical background for experiments and instrumentation used for chemical measurements. The course also includes an independent, student-designed air quality monitoring project. Prerequisites: CHEM 263 or 265; CHEM 213; CHEM 303 or 373. Note: Restricted to students in concentration in Chemistry programs or by consent of instructor.

Introduction to green chemistry. The twelve principles and the metrics of green chemistry; Chemical wastes: their impact on health and the environment, and prevention; Green solvents and alternate methods that use safer chemicals; Catalysis and green catalysts; Renewable resources. Prerequisite: CHEM 263. Students who have obtained credit for CHIM 340 cannot take CHEM 306 for credit.

A continuation of CHEM 213 delving more deeply into advanced concepts in chemical instrumentation including separations, mass spectrometry, optical spectroscopy and electrochemistry. Concepts of signals, electronics, and data interpretation are also explored and applied in the laboratory. Prerequisites: CHEM 213 and PHYS 124 or 144. PHYS 126 or 146 or 181 is recommended.

Fundamentals of the synthesis, structure and properties of inorganic solids, thin films, and nanoscale materials, to be complemented with case studies of modern applications of inorganic materials; selected topics such as catalysis, molecular and nanoparticle-based computing, telecommunications, alternative energies, superconductivity, biomedical technologies, and information storage will be discussed. Techniques for characterization and analysis of materials on the nano and atomic level will be introduced. Prerequisite: CHEM 241.

An extension of CHEM 241 with emphasis on the bonding, structure, and reactivity of transition-metal elements. The course will include applications in industrial, biochemical, environmental, and materials science. For students in Chemistry Honors, Specialization, and Major Programs only, except by consent of Department. Prerequisites: CHEM 241 or consent of Department. Students who have obtained credit for CHEM 243 cannot take CHEM 343 for credit.

Introduction to chemical strategies used to analyze and manipulate biochemical systems. Topics may include chemical synthesis of biopolymers, protein-small molecule interactions, chemoenzymatic synthesis, enzyme-inhibitor kinetics, assay design, characterization of bioorganic samples, and various chemical biology methods. Prerequisites: CHEM 263 or 265; BIOCH 200. Students who have obtained credit for CHEM 451 cannot take CHEM 351 for credit.

Mechanisms and reactions of aromatic and aliphatic compounds. Prerequisites: CHEM 102; CHEM 263, or CHEM 265 and 267.

A study of the implications of the laws of thermodynamics for transformations of matter including phase changes, chemical reactions, and biological processes. Topics include: thermochemistry; entropy change and spontaneity of processes; activity and chemical potential; chemical and phase equilibria; properties of solutions; simple one- and two-component phase diagrams. The conceptual development of thermodynamic principles from both macroscopic and molecular levels, and the application of these principles to systems of interest to chemists, biochemists, and engineers will be emphasized. Note: This course may not be taken for credit if credit has already been received in CHEM 271. Prerequisites: CHEM 102 or 105; MATH 101 or 115 or 136 or 146 or 156. Engineering students who take this course will receive 4.5 units.

A continuation of CHEM 371 in which the physical properties of chemical systems and the dynamics and energetics of chemical processes are discussed. Topics include: colligative properties; electrochemical cells and ion activities, implications for ionic equilibria; kinetic theory and transport properties of gases and liquids; surfaces and colloid chemistry; reaction dynamics, detailed mechanisms of chemical reactions, catalysis. The emphasis will be on the development of principles of physical chemistry and their application to properties and processes of interest to chemists, biochemists, and engineers. Note: This course may not be taken for credit if credit has already been received in CHEM 273 or 275. Prerequisite: CHEM 371 or 271.

An integrated course in the quantitative and more advanced aspects of spectroscopy and its applications in chemistry. The subjects may include: absorption, emission, dichroism, vibrational and rotational spectroscopy of molecules; time-resolved spectroscopy; nuclear magnetic resonance spectroscopy; surface-specific spectroscopies. A virtual molecular spectroscopy laboratory is included that incorporates the use of computers in predicting spectra and interpreting experimental results. Lab meetings will run for 6 - 8 weeks throughout the term. Prerequisite: CHEM 282.

A credit/no-credit course for participation in a research project under the direction of a member of the Department. Students taking CHEM 401 or 403 cannot concurrently take CHEM 399. Credit for this course may be obtained up to four times. Prerequisites: Departmental permission. 9 units of 200-level chemistry or 3 units of 300-level chemistry.

Introduction to methods of chemical research. Investigational work under the direction of a member of the Department. The results of the research will be submitted to the Department as a report and/or presentation which will be graded. For students in the fourth year of Chemistry Honors, Specialization, or Major Programs. Students should consult with the Course Coordinator four months prior to starting the course. Prerequisites: a 300-level CHEM course, minimum GPA of 3.0 on all courses credited to the degree to date, and consent of the Course Coordinator. Students who have credit in CHEM 499 cannot take CHEM 401 for credit.

Investigational work under the direction of a member of the Department. The results of the research will be submitted to the Department as a report, which will be graded. The student must also make an oral presentation of this work to the Department. Prerequisite: CHEM 401.

Prerequisites: a 300- level CHEM course and consent of Instructor; prerequisite courses vary, depending on topic. Course may be repeated for credit, provided there is no duplication of specific topic.

Optical spectroscopy and electrochemistry and principles and applications to chemical analysis. Electronic and vibrational spectroscopy for probing and monitoring chemical and biochemical systems. Electrode kinetics, mass transport, and voltammetry for electroanalysis. Prerequisite: CHEM 313.

Concepts and techniques in chromatography, mass spectrometry, and chromatography/MS combinations. Examples of modern instrumentation as well as applications to chemical, biochemical, and biomedical analysis. Prerequisite: CHEM 313.

An introduction to structure determination by single-crystal X-ray diffraction methods. Topics include X-ray diffraction, crystal symmetry, experimental methods, structure solution, refinement, crystallographic software, and interpretation of crystal structure data. Prerequisite: CHEM 243 and one 300-level CHEM course; or CHEM 343; or CHEM 333; or consent of the instructor.

Introduction to methods of synthesizing inorganic materials with control of atomic, meso- and micro-structure. Topics include sol-gel chemistry, chemical vapor deposition, solid state reactions, solid-state metathesis and high-temperature self-propagating reactions, template directed syntheses of micro and mesoporous materials, micelles and colloids, synthesis of nanoparticles and nanomaterials. Applications of these synthetic techniques to applications such as photonic materials, heterogeneous catalysts, magnetic data storage media, nanoelectronics, display technologies, alternative energy technologies, and composite materials will be discussed. Prerequisite: CHEM 243 and one 300 level CHEM course; or CHEM 343; or CHEM 333; or consent of the instructor.

An introduction to organotransition metal chemistry. The course will deal with the synthesis, basic bonding, and reactivity of organotransition metal complexes. Topics to be covered include transition metal complexes of hydrides, phosphines, carbonyls, olefins, alkynes, polyolefins, cyclopentadienyl and related cyclic pi-ligands; metal-carbon sigma- and multiple bonds. The application of these complexes to homogeneous catalysis and to organic synthesis will be discussed when appropriate. Prerequisite: CHEM 243 and one 300-level CHEM course; or CHEM 343; or consent of the instructor.

Introduction to the chemistry of extended inorganic solids. The topics covered include synthesis, symmetry, descriptive crystal chemistry, bonding, electronic band structures, characterization techniques, and phase diagrams. The correlation of structure with properties of electronic and magnetic materials will be discussed. Prerequisite: CHEM 243 and one 300-level CHEM course; or CHEM 343; or CHEM 333; or consent of the instructor.

An introductory course on asymmetric catalysis. Emphasis will be on reactions catalyzed by chiral transition metal complexes, but non-metal catalyzed reactions and heterogeneous catalysis will be covered. Topics include the general principles of catalysis; mechanisms of common steps in catalytic cycles; rapid pre-equilibrium and steady-state kinetic treatments of catalytic rates; the origins of catalytic selection; and the strategies and principles of new catalyst, ligand, and reaction development. The course will include a survey of common enantioselective catalytic reactions and daily examples from ASAP articles that illustrate the principles and theories being taught in the course. Introductory level knowledge of transition metal and organic chemistry is required. Prerequisite: CHEM 241 and one 300-level chemistry course.

Introduction to techniques in determining the composition and structure of materials on the nanometer scale. Characterization of atomic, meso-, and microstructure of materials including impurities and defects. Major topics will include electron microscopy (transmission, scanning, and Auger) and associated spectroscopies (EDX, EELS), surface sensitive spectroscopies (e.g., XPS, AES, IR) and spectrometry (SIMS), synchrotron techniques, X-ray absorption, fluorescence and emission, and scanned probe microscopies (AFM, STM, etc.). The strengths, weaknesses, and complementarity of the techniques used will be examined via case studies on the characterization of real-world nanotechnologies, such as heterogeneous catalysts, surfaces and interfaces in semiconductor devices, organic monolayers on metals and semiconductors, nanotube- and nanowire-based electronics, and biocompatible materials. Prerequisite: 4th year standing or consent of instructor.

Advanced methods used to analyze and manipulate biological systems using engineered biomolecules and synthetic organic molecules. Topics may include biomolecule structure and function, enzymology, molecular biology, protein engineering, genome engineering, bioinformatic methods, inhibitor design, library screening methods, fluorescent probes, bioorthogonal chemistry, and various chemical biology methods. Prerequisites: CHEM 351 or BIOCH 200; CHEM 361 (can be taken as co-requisite).

Discussion of organic reactions to modify or label biopolymers including proteins, carbohydrates, and nucleic acids. Topics will include mechanistic and methodological details of commonly employed reactions used for chemoselective labeling or modification of biomolecules to produce synthetic vaccines, antibody-drug conjugates, and native chemical ligation will be discussed. Prerequisites: CHEM 351 or BIOCH 200; CHEM 361. Note: This course may not be taken for credit if credit has already been received in CHEM 464.

Modern organic reactions and reactive intermediates. Cations, free radicals, radical ions, carbenes, metallocarbenes, arynes, and transition-metal catalysis. Mechanisms, transition-state conformational analysis and stereoelectronic effects. Diastereoselectivity. The laboratory is focused on multistep organic synthesis, featuring reactions drawn from the lecture topics. Prerequisites: Chem 361 or consent of instructor. Students with credit for Chem 363 cannot take Chem 460 for credit.

Introductory discussion of the physical techniques used in organic chemistry research for the separation/purification and structural elucidation of organic compounds. Emphasis is on the combined use of modern spectrometric techniques for structure determination, with particular focus on an introduction to modern NMR spectroscopy. Prerequisite: CHEM 363 or 460 or consent of Instructor.

Discussion of organic structural theories, intramolecular and intermolecular interactions in organic chemistry, and the mechanisms and reactive intermediates involved in organic reactions. Prerequisite: CHEM 363 or 460 or consent of Instructor.

Discussion of the different concepts of chemoselective, regioselective and stereoselective reactions of organic compounds. Main classes of reactions described are oxidations, reductions, functional group protection, and carbon-carbon bond formation methods for single, double, and triple bonds. Emphasis on modern methodology for organic synthesis, including asymmetric catalysis and transition-metal catalyzed methods such as cross-coupling chemistry. Prerequisite: CHEM 363 or CHEM 460 or consent of Instructor.

Application of the principles of molecular symmetry to molecular properties. Topics include group theory with emphasis on vibrational motion and normal vibrations; quantum mechanics of vibration and rotation; magnetic resonance spectroscopy; perturbation methods; selection rules in rotational, infrared, and Raman spectroscopy; molecular symmetry and molecular orbitals; electronic spectroscopy of polyatomic molecules. Prerequisite: CHEM 282 and one 300-level Chemistry course; or consent of Instructor.

Rate laws for simple and complex reactions, reaction mechanisms, potential energy surfaces, molecular dynamics, theories of reaction rates, catalysis, with application to gas and liquid phase reactions, photochemical reactions in chemistry and biology, and enzyme catalysis. Prerequisites: CHEM 273 or CHEM 373; MATH 215, PHYS 230, and a 300-level Chemistry course.

The focus is on applications in this course which introduces the student to contemporary computational quantum chemistry (Hartree-Fock, post-Hartree-Fock, and density functional theory methods), using the state of-the-art computer code GAMESS-US running on UNIX workstations and computer servers. Elementary introduction to the UNIX operating system is given. Subjects include: basis sets; optimization of molecular geometry; prediction of molecular properties; calculation of infra-red and Raman spectra; excited electronic states; solvent effects; computational thermochemistry; mechanisms of chemical reactions; visualization of results. Assignments in the course allow the student to acquire practical computational experience that relates to chemistry. Prerequisite: CHEM 282 and one 300-level chemistry course or consent of Instructor.

The fundamentals of statistical mechanics are covered to set up the theoretical framework for Molecular Dynamics (MD) simulation. The basic components of MD simulation are discussed in detail, followed by a brief foray into Monte Carlo simulation. A variety of applications are presented, including the study of structural properties of liquids, the calculation of diffusion coefficients for a solute in a solvent, and the calculation of reaction rate constants. A brief overview of methods for incorporating quantum effects into MD simulations is given. Computational exercises will be assigned to exemplify various topics encountered in the lectures. Prerequisite: CHEM 282 and CHEM 371; or consent of the instructor.

An advanced, two-term, research placement course where students complete chemical-based exploratory research under the direction of a faculty member of the Department. Research, professional development and seminar components are involved, preparing undergraduates to further build strong chemical foundations to succeed in graduate, industry, or professional school programs. Prerequisites: 4th-year standing in a Chemistry Honors, Specialization, or Major program, two 300-level CHEM courses, minimum GPA of 3.0 on all CHEM courses credited to the degree to date, and consent of instructor. Students who have credit in CHEM 401 cannot take CHEM 499 for credit.

An advanced, two-term, research placement course where students complete chemical-based exploratory research under the direction of a faculty member of the Department. Research, professional development and seminar components are involved, preparing undergraduates to further build strong chemical foundations to succeed in graduate, industry, or professional school programs. Prerequisites: 4th-year standing in a Chemistry Honors, Specialization, or Major program, two 300-level CHEM courses, minimum GPA of 3.0 on all CHEM courses credited to the degree to date, and consent of instructor. Students who have credit in CHEM 401 cannot take CHEM 499 for credit.

Course may be repeated.